Personal information

United Kingdom

Activities

Employment (7)

University of Bristol: Bristol, Bristol, GB

2018 to present | Graduate Dean for Life Sciences
Employment
Source: Self-asserted source
Harry Mellor

University of Bristol: Bristol, GB

2010 to present | Professor of Biochemistry (Biochemistry)
Employment
Source: Self-asserted source
Harry Mellor

University of Bristol: Bristol, GB

2005 to 2010 | Reader (Biochemistry)
Employment
Source: Self-asserted source
Harry Mellor

University of Bristol: Bristol, Bristol, GB

2003 to 2008 | Welcome Trust University Award (Biochemistry)
Employment
Source: Self-asserted source
Harry Mellor

University of Bristol: Bristol, Bristol, GB

1998 to 2003 | Wellcome Trust Career Development Fellowship (Biochemistry)
Employment
Source: Self-asserted source
Harry Mellor

Cancer Research UK LRI: London, GB

1995 to 1998 | Postdoctoral Fellow
Employment
Source: Self-asserted source
Harry Mellor

Penn State University: Hershey, US

1993 to 1995 | Juvenile Diabetes Foundation International Personal Fellowship (Cellular Molecular Physiology)
Employment
Source: Self-asserted source
Harry Mellor

Education and qualifications (2)

University of Bristol: Bristol, Bristol, GB

1988 to 1992 | PhD Biochemistry
Education
Source: Self-asserted source
Harry Mellor

University of Edinburgh: Edinburgh, Edinburgh, GB

1985 to 1988 | BSc Biochemistry
Education
Source: Self-asserted source
Harry Mellor

Professional activities (2)

British Society for Cell Biology: Oxford, Oxfordshire, GB

Membership
Source: Self-asserted source
Harry Mellor

Biochemical Society: London, London, GB

Membership
Source: Self-asserted source
Harry Mellor

Funding (3)

Mechanisms of neovascularization: Signalling from VEGFR1 to the cytoskeleton through RhoA

2017 to 2020 | Grant
British Heart Foundation (London, GB)
Source: Self-asserted source
Harry Mellor

Mechanisms of neovascularisation: RhoJ, FMNL3 and the formation of vascular lumens

2016 to 2019 | Grant
British Heart Foundation (London, GB)
Source: Self-asserted source
Harry Mellor

Ehd proteins, VEGF-signalling and loss of glomerular endothelial cell fenestrations in the pathophysiology of diabetic nephropathy

2014 to 2019 | Grant
Wellcome Trust (London, GB)
Source: Self-asserted source
Harry Mellor

Works (50 of 79)

Items per page:
Page 1 of 2

Cyclic-AMP Increases Nuclear Actin Monomer Which Promotes Proteasomal Degradation of RelA/p65 Leading to Anti-Inflammatory Effects

Cells
2022-04-21 | Journal article
Contributors: Joseph W. Hawkins; Madeleine C. McNeill; Reza Ebrahimighaei; Harry H. Mellor; Andrew C. Newby; Mark Bond
Source: check_circle
Crossref

srGAP2 deactivates RhoA to control the duration of thrombin-mediated endothelial permeability

Vascular Biology
2022-03-01 | Journal article
Contributors: Alba Lopez Rioja; Ashton Faulkner; Harry Mellor
Source: check_circle
Crossref

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

Diabetologia
2020-10-30 | Journal article
Contributors: Ashton Faulkner; Anita Tamiato; William Cathery; Andrea Rampin; Carlo Maria Caravaggi; Eva Jover; Steve Allen; Harry Mellor; David Hauton; Lisa C. Heather et al.
Source: check_circle
Crossref

Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling

Angiogenesis
2020-08-09 | Journal article
Contributors: Asha L. Bayliss; Ananthalakshmy Sundararaman; Camille Granet; Harry Mellor
Source: check_circle
Crossref

RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis

Current Biology
2020-06 | Journal article
Contributors: Ananthalakshmy Sundararaman; Yoko Fukushima; Jim C. Norman; Akiyoshi Uemura; Harry Mellor
Source: check_circle
Crossref

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

The EMBO journal
2018-06 | Journal article
Contributors: Gurevich DB; Severn CE; Twomey C; Greenhough A; Cash J; Toye AM; Mellor H; Martin P
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B

BMC Cancer
2017-12 | Journal article
Contributors: Caroline M. McKinnon; Harry Mellor
Source: check_circle
Crossref

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Antioxidants & redox signaling
2017-09 | Journal article
Contributors: Vara D; Watt JM; Fortunato TM; Mellor H; Burgess M; Wicks K; Mace K; Reeksting S; Lubben A; Wheeler-Jones CPD et al.
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

In Vitro Coculture Assays of Angiogenesis

Angiogenesis Protocols
2016 | Other
Part of ISBN: 9781493936267
Part of ISSN: 1064-3745
Contributors: Mark Richards; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

Current Biology
2015-08 | Journal article
Part of ISSN: 0960-9822
Contributors: Mark Richards; Clare Hetheridge; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction

Neuroscience Letters
2015-03 | Journal article
DOI:

10.1016/j.neulet.2015.02.010

Contributors: Lifei Fan; Huijuan Yan; Stephanie Pellegrin; Morigen; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search
grade
Preferred source (of 2)‎

Platelet Rho GTPases–a focus on novel players, roles and relationships

Biochem. J.
2015-03-06 | Journal article
DOI:

10.1042/bj20141404

Contributors: Robert Goggs; Christopher M. Williams; Harry Mellor; Alastair W. Poole
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The Coculture Organotypic Assay of Angiogenesis

Vascular Morphogenesis
2014-10 | Other
DOI:

10.1007/978-1-4939-1462-3_17

Contributors: Jennifer L. Allen; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

RNA Interference Approaches to Examine Golgi Function in Animal Cell Culture

Methods for Analysis of Golgi Complex Function
2013 | Other
DOI:

10.1016/b978-0-12-417164-0.00002-1

Contributors: Victoria J. Miller; Caroline M. McKinnon; Harry Mellor; David J. Stephens
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

RhoG protein regulates platelet granule secretion and thrombus formation in mice.

2013-11 | Journal article
DOI:

10.1074/jbc.M113.504100

PMID:

24106270

PMC:

PMC3837162

Contributors: Goggs R; Harper MT; Pope RJ; Savage JS; Williams CM; Mundell SJ; Heesom KJ; Bass M; Mellor H; Poole AW
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The Small GTPase Rif Is Dispensable for Platelet Filopodia Generation in Mice

PLoS ONE
2013-01 | Journal article
DOI:

10.1371/journal.pone.0054663

Contributors: Robert Goggs; Joshua S. Savage; Harry Mellor; Alastair W. Poole; Pontus Aspenstrom
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The formin FMNL3 is a cytoskeletal regulator of angiogenesis.

2012-03 | Journal article
DOI:

10.1242/jcs.091066

PMID:

22275430

PMC:

PMC3656618

Contributors: Hetheridge C; Scott AN; Swain RK; Copeland JW; Higgs HN; Bicknell R; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The small Rho GTPase Rif and actin cytoskeletal remodelling

Biochem. Soc. Trans.
2012-01 | Journal article
DOI:

10.1042/bst20110625

Contributors: Lifei Fan; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Uses of the in vitro endothelial–fibroblast organotypic co-culture assay in angiogenesis research

Biochem. Soc. Trans.
2011-11 | Journal article
DOI:

10.1042/bst20110738

Contributors: Clare Hetheridge; Georgia Mavria; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Site recognition and substrate screens for PKN family proteins

Biochem. J.
2011-08 | Journal article
DOI:

10.1042/bj20110521

Contributors: Alejandra Collazos; Nicholas Michael; Richard D. H. Whelan; Gavin Kelly; Harry Mellor; Leon C. H. Pang; Nick Totty; Peter J. Parker
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

RhoBTB2 in breast cancer.

2010 | Journal article
PMC:

PMC2875581

Contributors: McKinnon C; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells.

2010-04 | Journal article
DOI:

10.1242/jcs.061754

PMID:

20233848

PMC:

PMC2848113

Contributors: Fan L; Pellegrin S; Scott A; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The role of formins in filopodia formation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2010-02 | Journal article
DOI:

10.1016/j.bbamcr.2008.12.018

Contributors: Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

VEGF receptor trafficking in angiogenesis

Biochem. Soc. Trans
2009 | Journal article
DOI:

10.1042/bst0371184

Contributors: Alice Scott; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

RhoBTB Proteins in Cancer

The Rho GTPases in Cancer
2009-10 | Other
DOI:

10.1007/978-1-4419-1111-7_7

Contributors: Caroline McKinnon; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching

Traffic
2009-06 | Journal article
DOI:

10.1111/j.1600-0854.2009.00898.x

Contributors: Matthew C. Jones; Patrick T. Caswell; Kim Moran-Jones; Marnie Roberts; Simon T. Barry; Alexandra Gampel; Harry Mellor; Jim C. Norman
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells.

2008-11 | Journal article
DOI:

10.1038/onc.2008.317

PMID:

18762809

Contributors: McKinnon CM; Lygoe KA; Skelton L; Mitter R; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis

Angiogenesis
2008-08 | Journal article
DOI:

10.1007/s10456-008-9115-3

Contributors: Alice N. Scott; Clare Hetheridge; Andrew R. Reynolds; Vrinda Nayak; Kairbaan Hodivala-Dilke; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway

Veterinary Microbiology
2008-07 | Journal article
DOI:

10.1016/j.vetmic.2008.01.003

Contributors: Samantha Passey; Andrew Bradley; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Actin stress fibres.

2007-10 | Journal article
DOI:

10.1242/jcs.018473

PMID:

17928305

Contributors: Pellegrin S; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor.

2007-06 | Journal article
DOI:

10.1095/biolreprod.106.058982

PMID:

17301291

Contributors: Lartey J; Smith M; Pawade J; Strachan B; Mellor H; López Bernal A
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment.

2006-10 | Journal article
DOI:

10.1182/blood-2005-12-007484

PMID:

16638931

Contributors: Gampel A; Moss L; Jones MC; Brunton V; Norman JC; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Expression of RND proteins in human myometrium.

2006-09 | Journal article
DOI:

10.1095/biolreprod.105.049130

PMID:

16554414

Contributors: Lartey J; Gampel A; Pawade J; Mellor H; Bernal AL
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Evolution of the Human Rho GTPase Family

RHO Family GTPases
2005 | Other
DOI:

10.1007/1-4020-3462-8_2

Contributors: Stephanie Pellegrin; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells.

2005 | Journal article
PMID:

15649143

Contributors: Curnow P; Mellor H; Stephens DJ; Lorch M; Booth PJ
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

The Rho Family GTPase Rif Induces Filopodia through mDia2

Current Biology
2005-01 | Journal article
DOI:

10.1016/j.cub.2005.01.011

Contributors: Stéphanie Pellegrin; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

RhoB and Actin Polymerization Coordinate Src Activation with Endosome-Mediated Delivery to the Membrane

Developmental Cell
2004 | Journal article
DOI:

10.1016/j.devcel.2004.09.019

Contributors: Emma Sandilands; Christophe Cans; Valerie J. Fincham; Valerie G. Brunton; Harry Mellor; George C. Prendergast; Jim C. Norman; Giulio Superti-Furga; Margaret C. Frame
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

What is in a filopodium? Starfish versus hedgehogs.

2004-12 | Journal article
PMID:

15506983

Contributors: Passey S; Pellegrin S; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

siRNA approaches in cell biology

Encyclopedia of Genetics, Genomics, Proteomics and Bioinformatics
2004-10 | Other
DOI:

10.1002/047001153x.g304407

Contributors: Alexandra Gampel; Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Sorting Nexin-1 Mediates Tubular Endosome-to-TGN Transport through Coincidence Sensing of High- Curvature Membranes and 3-Phosphoinositides

Current Biology
2004-10 | Journal article
DOI:

10.1016/j.cub.2004.09.077

Contributors: Jez Carlton; Miriam Bujny; Brian J. Peter; Viola M.J. Oorschot; Anna Rutherford; Harry Mellor; Judith Klumperman; Harvey T. McMahon; Peter J. Cullen
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase.

2004-07 | Journal article
DOI:

10.1242/jcs.01193

PMID:

15226397

Contributors: Wherlock M; Gampel A; Futter C; Mellor H
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Cell Motility: Golgi Signalling Shapes up to Ship out

Current Biology
2004-06 | Journal article
DOI:

10.1016/j.cub.2004.05.038

Contributors: Harry Mellor
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

S1P and LPA trigger Schwann cell actin changes and migration

European Journal of Neuroscience
2004-06 | Journal article
DOI:

10.1111/j.0953-816x.2004.03424.x

Contributors: Siân C. Barber; Harry Mellor; Alex Gampel; Neil J. Scolding
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cells

Cellular Microbiology
2003-11 | Journal article
DOI:

10.1046/j.1462-5822.2003.00315.x

Contributors: Mark A. Jepson; Stephanie Pellegrin; Leon Peto; David N. Banbury; Alan D. Leard; Harry Mellor; Brendan Kenny
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Regulation of endocytic traffic by Rho GTPases

Biochem. J.
2003-04 | Journal article
DOI:

10.1042/bj20030139

Contributors: Britta QUALMANN; Harry MELLOR
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP

European Journal of Biochemistry
2002 | Journal article
DOI:

10.1046/j.1432-1033.2002.03343.x

Contributors: Hortensia Mircescu; Séverine Steuve; Valérie Savonet; Chantal Degraef; Harry Mellor; Jacques E. Dumont; Carine Maenhaut; Isabelle Pirson
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.

2002-12 | Journal article
DOI:

10.1074/jbc.M206986200

PMID:

12198132

Contributors: Cozier GE; Carlton J; McGregor AH; Gleeson PA; Teasdale RD; Mellor H; Cullen PJ
Source: Self-asserted source
Harry Mellor via Europe PubMed Central

Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo

Biochem. J.
2002-09-01 | Journal article
DOI:

10.1042/bj20020844

Contributors: Alexandra GAMPEL; Harry MELLOR
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules

Molecular Microbiology
2002-05 | Journal article
DOI:

10.1046/j.1365-2958.2002.02952.x

Contributors: Brendan Kenny; Sarah Ellis; Alan D. Leard; Jonathan Warawa; Harry Mellor; Mark A. Jepson
Source: Self-asserted source
Harry Mellor via Crossref Metadata Search

Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A.

2002-01 | Journal article
DOI:

10.1016/S0028-3908(01)00161-7

PMID:

11750911

Contributors: Kanumilli S; Toms NJ; Venkateswarlu K; Mellor H; Roberts PJ
Source: Self-asserted source
Harry Mellor via Europe PubMed Central
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