Ian Alexander Graham (0000-0003-4007-1770)

Personal information

Biography

Ian Graham’s interests include how plants make and breakdown various metabolites, how these processes are controlled and how they impact on plant growth. He has used biochemical genetics to dissect the main metabolic pathways controlling oil mobilisation in Arabidopsis seed and provided new insight into how a lipid based signal controls seed germination. He has used similar approaches to investigate the synthesis of bioactive compounds in two of the world’s major medicinal crops. This has led to new understanding of how genome rearrangement has shaped the evolution of plant metabolism. The discovery of a 10 gene cluster responsible for the production of the anti-cancer compound noscapine in opium poppy provided the tools for molecular breeding of new commercial varieties. The discovery of a novel P450 – oxidoreductase gene fusion described the last unknown step in synthesis of morphine and codeine. Characterisation and genetic mapping of traits responsible for production of artemisinin in Artemisia annua has enabled development of F1 hybrid seed that can deliver a robust source of this vital anti-malarial drug for the developing world.

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University of York: York, GB

2020 to present | Academic Director of BioYorkshire

Employment

Ian Alexander Graham

https://orcid.org/0000-0003-4007-1770

Personal information

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Biography

Activities

Employment (6)

University of York: York, GB

University of York: York, York, GB

University of York: York, GB

University of York: York, GB

University of York: York, GB

University of York: York, GB

Education and qualifications (2)

University of Edinburgh: Edinburgh, GB

Queen's University Belfast: Belfast, GB

Professional activities (3)

European Molecular Biology Organization: Heidelberg, DE

Royal Society: London, GB

Biochemical Society: London, GB

Funding (21)

Bioactive terpenoids as high performance ingredients for industry

Centre for High Carbon Capture Cropping (CHCx3)

Fast and Sensitive Mass Spectrometry

High Value Biorenewables (HVB) Network

Harnessing the benefits of African leafy vegetables for smallholder farmers and their households

High definition ion-mobility mass spectrometry and imaging for metabolomics, lipidomics and glycomics

Assessing treatment with miltefosine as an intervention strategy for visceral leishmaniasis in Brazil

Developing platforms for the production of diterpenoids (TSB application reference 43970-304155)

Light-independent sugar signalling in Arabidopsis

High Value Chemicals from Plants Network

Understanding the regulation of alkaloid biosynthesis in opium poppy and breeding new varieties

FLIP: Developing biorenewables based feedstock and clean chemistry technologies for the pharmaceutical industry

Using wild ancestor plants to make rice more resilient to increasingly unpredictable water availability

Integrated Biorefining Research and Technology Club - University of York

The role of the oxylipin OPDA in the seasonal sensitivity of seed dormancy

MSc in Bioscience Technology

BBSRC Targeted Priority Studentship Bid Biology_York 2008

Regulation of biological signalling by temperature (ROBUST)

Defining the role of the ABI4 transcription factor in the sugar regulated control of storage oil breakdown in Arabidopsis

Defining the role of PIF3-like bHLH transcription factors in the integration of light and cold signalling in Arabidopsis

Metabolomic and transcriptomic analysis of the controls on carbon partitioning into TAG reserves in oilseeds

Works (50 of 138)

BAHD news fromEuphorbia peplus: identification of acyltransferase enzymes involved in ingenane diterpenoid biosynthesis

An Engineered Heat-Inducible Expression System for the Production of Casbene in Nicotiana benthamiana

3’Nucleotidase/nuclease is required for Leishmania infantum clinical isolate susceptibility to miltefosine

Artemisia annua L. plants lacking Bornyl diPhosphate Synthase reallocate carbon from monoterpenes to sesquiterpenes except artemisinin

Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield

Author correction (erratum) to 'A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago'

A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago

Gene discovery and virus induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in Euphorbia peplus

Plant metabolic gene clusters in the multi-omics era

Impact on Arabidopsis growth and stress resistance of depleting the Maf1 repressor of RNA polymerase III

Engineering production of a novel diterpene synthase precursor in Nicotiana benthamiana

A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago

Developing a Nicotiana benthamiana transgenic platform for high‐value diterpene production and candidate gene evaluation

A chromosome-level Amaranthus cruentus genome assembly highlights gene family evolution and biosynthetic gene clusters that may underpin the nutritional value of this traditional crop

Superoxide is promoted by sucrose and affects amplitude of circadian rhythms in the evening

Selection of a subspecies-specific diterpene gene cluster implicated in rice disease resistance

Impact of osmotic stress on the growth and root architecture of introgression lines derived from a wild ancestor of rice and a modern cultivar

Editorial: Artemisinin-From Traditional Chinese Medicine to Artemisinin Combination Therapies; Four Decades of Research on the Biochemistry, Physiology, and Breeding of Artemisia annua

Untapped resources for medical research

ABA INSENSITIVE4 promotes rather than represses PHYA‐dependent seed germination in Arabidopsis thaliana

Combining GAL4 GFP enhancer trap with split luciferase to measure spatiotemporal promoter activity in Arabidopsis

Over 100 Million Years of Enzyme Evolution Underpinning the Production of Morphine in the Papaveraceae Family of Flowering Plants

cis-12-Oxo-phytodienoic acid represses Arabidopsis seed germination in shade conditions

Flavonoid versus artemisinin anti-malarial activity in Artemisia annua whole-leaf extracts

Control of seed coat rupture by ABA-INSENSITIVE 5 in Arabidopsis thaliana

Structure of Papaver somniferum O-Methyltransferase 1 Reveals Initiation of Noscapine Biosynthesis with Implications for Plant Natural Product Methylation

Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis

Contrasting nutrient–disease relationships: Potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid

The opium poppy genome and morphinan production

MOTHER-OF-FT-AND-TFL1 represses seed germination under far-red light by modulating phytohormone responses in Arabidopsis thaliana

Silencing amorpha-4,11-diene synthase genes in Artemisia annua leads to FPP accumulation.

Detailed phytochemical analysis of high- and low artemisinin-producing chemotypes of Artemisia annua.

An oleuropein β-glucosidase from olive fruit is involved in determining the phenolic composition of virgin olive oil

Jasmonic acid-dependent regulation of seed dormancy following maternal herbivory in Arabidopsis

Molecular mechanisms underlying the entrance in secondary dormancy of Arabidopsis seeds

Artemisia annua mutant impaired in artemisinin synthesis demonstrates importance of nonenzymatic conversion in terpenoid metabolism

A cytochrome P450-mediated intramolecular carbon-carbon ring closure in the biosynthesis of multidrug resistance-reversing lathyrane diterpenoids