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Keywords

systems biology, mathematical modelling, cancer signalling

Countries

Australia

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Employment (2)

Monash University: Melbourne, AU

2015 to present | Laboratory Head (Group Leader) (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Lan Nguyen

Systems Biology Ireland, University College Dublin: Dublin, IE

2010 to 2014 | Postdoctoral researcher
Employment
Source: Self-asserted source
Lan Nguyen

Education and qualifications (2)

Lincoln University: Christchurch, NZ

2006 to 2009 | PhD (Biosciences)
Education
Source: Self-asserted source
Lan Nguyen

Lincoln University: Christchurch, NZ

2001 to 2004 | Applied Mathematics and Computing
Education
Source: Self-asserted source
Lan Nguyen

Funding (3)

Platform Access Grants

2015 to 2026 | Grant
Monash University (VIC, VIC, AU)
Source: Self-asserted source
Lan Nguyen

Project Grant

2014 to 2016 | Grant
Breast Cancer Campaign (London, GB)
Source: Self-asserted source
Lan Nguyen

Career Development Award

2013 to 2014 | Grant
University College Dublin (Dublin, IE)
Source: Self-asserted source
Lan Nguyen

Works (50 of 61)

Items per page:
Page 1 of 2

From shallow to deep: The evolution of machine learning and mechanistic model integration in cancer research

Current Opinion in Systems Biology
2025-03 | Journal article
DOI: 10.1016/j.coisb.2025.100541
Contributors: Yunduo Lan; Sung-Young Shin; Lan K. Nguyen
Source: check_circle
Crossref

Ribosomal Biogenesis Hyperactivation and ErbB signalling Mediated Network Rewiring Causes Adaptive Resistance to FGFR2 Inhibition

2024-10-29 | Preprint
DOI: 10.1101/2024.10.27.620536
Contributors: Tao Zhang; Sung-Young Shin; Callan McCrimmon; Mandy Theocharous; Ralf B Schittenhelm; Thierry Jarde; Roger J Daly; Lan K Nguyen
Source: check_circle
Crossref

Data from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.c.7474590
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

Cancer Research
2024-10-01 | Journal article
DOI: 10.1158/0008-5472.CAN-23-3409
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142911
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data S1 from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142926
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data S2 from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142923
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data S3 from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142920
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data S4 from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142917
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Supplementary Data S5 from Integrative Modeling of Signaling Network Dynamics Identifies Cell Type–Selective Therapeutic Strategies for FGFR4-Driven Cancers

2024-10-01 | Preprint
DOI: 10.1158/0008-5472.27142914
Contributors: Sung-Young Shin; Nicole J. Chew; Milad Ghomlaghi; Anderly C. Chüeh; Yunhui Jeong; Lan K. Nguyen; Roger J. Daly
Source: check_circle
Crossref

Stress pathway outputs are encoded by pH-dependent clustering of kinase components

Nature Communications
2024-08-05 | Journal article
DOI: 10.1038/s41467-024-50638-w
Contributors: Yuliia Didan; Milad Ghomlaghi; Lan K. Nguyen; Dominic C. H. Ng
Source: check_circle
Crossref

Integrative modeling and analysis of signaling crosstalk reveal molecular switches coordinating Yes-associated protein transcriptional activities

iScience
2024-03 | Journal article
DOI: 10.1016/j.isci.2024.109031
Contributors: Milad Ghomlaghi; Mandy Theocharous; Nhan Hoang; Sung-Young Shin; Alex von Kriegsheim; Eric O’ Neill; Tao Zhang; Lan K. Nguyen
Source: check_circle
Crossref

GeneSurv: Multi-Gene Cancer Survival Analysis Tool

2024-03-19 | Preprint
DOI: 10.1101/2024.03.17.583882
Contributors: Zikang Xu; Jamin Wu; Sung-young Shin; Lan K. Nguyen
Source: check_circle
Crossref

Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

2023-09-01 | Preprint
DOI: 10.7554/eLife.87710
Contributors: Anthony Hart; Sung-Young Shin; Lan K. Nguyen
Source: check_circle
Crossref

Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

2023-09-01 | Preprint
DOI: 10.7554/eLife.87710.1
Contributors: Anthony Hart; Sung-Young Shin; Lan K. Nguyen
Source: check_circle
Crossref

SynDISCO: A Mechanistic Modeling-Based Framework for Predictive Prioritization of Synergistic Drug Combinations Directed at Cell Signaling Networks

2023-04-08 | Preprint
DOI: 10.1101/2023.04.07.536087
Contributors: Sung-Young Shin; Lan K. Nguyen
Source: check_circle
Crossref

The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

Oncogene
2023-03-10 | Journal article
DOI: 10.1038/s41388-023-02594-w
Contributors: Xue Yang; Miguel I. Cruz; Elizabeth V. Nguyen; Cheng Huang; Ralf B. Schittenhelm; Jennii Luu; Karla J. Cowley; Sung-Young Shin; Lan K. Nguyen; Terry C. C. Lim Kam Sian et al.
Source: check_circle
Crossref

Systematic Analysis of Network-driven Adaptive Resistance to CDK4/6 and Estrogen Receptor Inhibition using Meta-Dynamic Network Modelling

2023-01-25 | Preprint
DOI: 10.1101/2023.01.24.525460
Contributors: Anthony Hart; Sung-Young Shin; Lan K. Nguyen
Source: check_circle
Crossref

Systems modelling of TGF-β/Hippo signalling crosstalk uncovers molecular switches that coordinate YAP transcriptional complexes (submitted to iScience)

2022-04-08 | Preprint
DOI: 10.1101/2022.04.06.487403
Contributors: Milad Ghomlaghi; Mandy Theocharous; Sung-Young Shin; Eric O’ Neill; Lan K. Nguyen
Source: check_circle
Crossref

Dynamic modelling of the PI3K/MTOR signalling network uncovers biphasic dependence of mTORC1 activity on the mTORC2 subunit SIN1

PLOS Computational Biology
2021-09-16 | Journal article
DOI: 10.1371/journal.pcbi.1008513
Contributors: Milad Ghomlaghi; Stacey Finley; Guang Yang; Sung-Young Shin; David E. James; Lan K. Nguyen
Source: check_circle
Crossref

Dynamic modelling of the PI3K/mTOR signalling network uncovers biphasic dependence of mTORC1 activation on the mTORC2 subunit Sin1

2020-11-30 | Preprint
DOI: 10.1101/2020.11.30.403774
Contributors: Milad Ghomlaghi; Sungyoung Shin; Guang Yang; David E. James; Lan K. Nguyen
Source: check_circle
Crossref

Coupled feedback regulation of nuclear factor of activated T-cells (NFAT) modulates activation-induced cell death of T cells

Scientific Reports
2019-07-23 | Journal article
DOI: 10.1038/s41598-019-46592-z
Contributors: Sung-Young Shin; Min-Wook Kim; Kwang-Hyun Cho; Lan K. Nguyen
Source: check_circle
Crossref

LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Nature Communications
2019-01-24 | Journal article
DOI: 10.1038/s41467-019-08335-6
Contributors: Benjamin Scott Padman; Thanh Ngoc Nguyen; Louise Uoselis; Marvin Skulsuppaisarn; Lan K. Nguyen; Michael Lazarou
Source: check_circle
Crossref

Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer

PLOS Computational Biology
2018-06-19 | Journal article
DOI: 10.1371/journal.pcbi.1006192
Contributors: Sung-Young Shin; Avi Ma'ayan; Anna-Katharina Müller; Nandini Verma; Sima Lev; Lan K. Nguyen
Source: check_circle
Crossref

Unveiling Hidden Dynamics of Hippo Signalling: A Systems Analysis

Genes
2016-07-29 | Journal article
Source: Self-asserted source
Lan Nguyen

HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status.

Oncotarget
2016-06 | Journal article
Source: Self-asserted source
Lan Nguyen

miR-143/PUMA cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.

Autophagy
2016-06 | Journal article
Source: Self-asserted source
Lan Nguyen

Dynamics of ubiquitin-mediated signalling: insights from mathematical modelling and experimental studies.

2016-05 | Journal article
DOI: 10.1093/bib/bbv052
PMID: 26210356
Contributors: Nguyen LK
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Molecular Mechanisms Involving Sigma-1 Receptor in Cell Apoptosis of BV-2 Microglial Cells Induced by Methamphetamine.

CNS Neurol Disord Drug Targets
2016-05-18 | Journal article
Source: Self-asserted source
Lan Nguyen

Dissecting cell-fate determination through integrated modelling of the ERK/MAPK signalling pathway.

Methods in Molecular Biology (in press)
2016-04 | Book chapter
Source: Self-asserted source
Lan Nguyen

Non-linear dynamics in transcriptional regulation: biological logic gates

Springer (accepted)
2016-04 | Journal article
Source: Self-asserted source
Lan Nguyen

Understanding complexity in the HIF signaling pathway using systems biology and mathematical modeling.

2016-04 | Journal article
DOI: 10.1007/s00109-016-1383-6
PMID: 26821588
Contributors: Fábián Z; Taylor CT; Nguyen LK
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Substrate-Trapped Interactors of PHD3 and FIH Cluster in Distinct Signaling Pathways.

2016-03 | Journal article
DOI: 10.1016/j.celrep.2016.02.043
PMID: 26972000
PMC: PMC4805855
Contributors: Rodriguez J; Pilkington R; Garcia Munoz A; Nguyen LK; Rauch N; Kennedy S; Monsefi N; Herrero A; Taylor CT; von Kriegsheim A
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Feedback regulation in cell signalling: Lessons for cancer therapeutics.

2016-02 | Journal article
DOI: 10.1016/j.semcdb.2015.09.024
PMID: 26481970
Contributors: Nguyen LK; Kholodenko BN
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches.

2016-01 | Journal article
DOI: 10.1016/j.cels.2016.01.003
PMID: 27136688
PMC: PMC4802415
Contributors: Byrne KM; Monsefi N; Dawson JC; Degasperi A; Bukowski-Wills JC; Volinsky N; Dobrzyński M; Birtwistle MR; Tsyganov MA; Kiyatkin A et al.
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

2016-01 | Journal article
DOI: 10.1002/anie.201509272
PMID: 26644280
Contributors: Jambrina PG; Rauch N; Pilkington R; Rybakova K; Nguyen LK; Kholodenko BN; Buchete NV; Kolch W; Rosta E
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device.

2015 | Journal article
DOI: 10.4161/15384101.2014.973743
PMID: 25607644
PMC: PMC4353221
Contributors: Nguyen LK; Matallanas DG; Romano D; Kholodenko BN; Kolch W
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks.

2015 | Journal article
DOI: 10.1038/srep12569
PMID: 26220783
PMC: PMC4518224
Contributors: Nguyen LK; Degasperi A; Cotter P; Kholodenko BN
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Relationship between serum response factor and androgen receptor in prostate cancer.

2015-11 | Journal article
DOI: 10.1002/pros.23051
PMID: 26250344
Contributors: Prencipe M; O'Neill A; O'Hurley G; Nguyen LK; Fabre A; Bjartell A; Gallagher WM; Morrissey C; Kay EW; Watson RW
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

MST2-RASSF protein-protein interactions through SARAH domains.

2015-10 | Journal article
PMID: 26443615
Contributors: Sánchez-Sanz G; Matallanas D; Nguyen LK; Kholodenko BN; Rosta E; Kolch W; Buchete NV
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Protein-protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose-responses.

2015-10 | Journal article
DOI: 10.1039/c5mb00385g
PMID: 26266875
Contributors: Varusai TM; Kolch W; Kholodenko BN; Nguyen LK
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate.

2015-06 | Journal article
DOI: 10.1007/s00018-015-1850-1
PMID: 25697863
PMC: PMC4439527
Contributors: Nguyen LK; Cavadas MA; Kholodenko BN; Frank TD; Cheong A
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network.

2015-01 | Journal article
DOI: 10.1242/jcs.167304
PMID: 25589793
Contributors: Nguyen LK; Cavadas MA; Scholz CC; Fitzpatrick SF; Bruning U; Cummins EP; Tambuwala MM; Manresa MC; Kholodenko BN; Taylor CT et al.
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Ng. Her2–3 heterodimer is a new and better than HER2 IHC score for clinical outcome prognosis (2014)

European Journal of Cancer
2014 | Conference abstract
Source: Self-asserted source
Lan Nguyen

Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation.

2014 | Journal article
DOI: 10.3389/fphys.2014.00004
PMID: 24478717
PMC: PMC3901042
Contributors: Nguyen LK; Dobrzyński M; Fey D; Kholodenko BN
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing.

2014-12 | Journal article
DOI: 10.1049/iet-syb.2014.0024
PMID: 25478702
Contributors: Nguyen LK; Zhao Q; Varusai TM; Kholodenko BN
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Integrated signaling pathway and gene expression regulatory model to dissect dynamics of Escherichia coli challenged mammary epithelial cells.

2014-10 | Journal article
PMID: 25289583
Contributors: den Breems NY; Nguyen LK; Kulasiri D
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

2014-09 | Journal article
DOI: 10.1098/rsif.2014.0383
PMID: 24966234
PMC: PMC4233687
Contributors: Dobrzyński M; Nguyen LK; Birtwistle MR; von Kriegsheim A; Blanco Fernández A; Cheong A; Kolch W; Kholodenko BN
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

2014-08 | Journal article
DOI: 10.1126/scisignal.2005157
PMID: 25140053
Contributors: Kiuchi T; Ortiz-Zapater E; Monypenny J; Matthews DR; Nguyen LK; Barbeau J; Coban O; Lawler K; Burford B; Rolfe DJ et al.
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling.

2014-07 | Journal article
DOI: 10.1038/ncb2986
PMID: 24929361
Contributors: Romano D; Nguyen LK; Matallanas D; Halasz M; Doherty C; Kholodenko BN; Kolch W
Source: Self-asserted source
Lan Nguyen via Europe PubMed Central
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Peer review (12 reviews for 7 publications/grants)

Review activity for BMC bioinformatics (1)
Review activity for Cell reports. (1)
Review activity for Cell systems. (1)
Review activity for Current opinion in systems biology. (2)
Review activity for eLife (1)
Review activity for iScience. (5)
Review activity for npj systems biology and applications. (1)
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