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Employment (1)

Duke-NUS Medical School: Singapore, --- Select a state ---, SG

2017 to present | Research Fellow (Cancer and Stem Cell Biology)
Employment
Source: Self-asserted source
Kie Kyon Huang

Education and qualifications (1)

Cancer Science Institute of Singapore: Singapore, SG

2012 to 2017 | PhD in Cancer Biology
Education
Source: Self-asserted source
Kie Kyon Huang

Funding (1)

Clonal Evolution of Cancer Alterations in Premalignant Gastric Cancer

2019 to 2021 | Grant
Khoo Postdoctoral Fellowship Award (Singapore, SG)
Source: Self-asserted source
Kie Kyon Huang

Works (27)

Spatially Resolved Tumor Ecosystems and Cell States in Gastric Adenocarcinoma Progression and Evolution.

Cancer discovery
2025-01-09 | Journal article | Author
Contributors: Haoran Ma; Supriya Srivastava; Shamaine Wei Ting Ho; Chang XU; Benedict Shi Xiang Lian; Thaleia Ong; Su Ting Tay; Taotao Sheng; Huey Yew Jeffrey Lum; Siti Aishah Binte Abdul Ghani et al.
Source: Self-asserted source
Kie Kyon Huang

Phase I PIANO trial-PIPAC-oxaliplatin and systemic nivolumab combination for gastric cancer peritoneal metastases: clinical and translational outcomes.

ESMO open
2024-09-16 | Journal article
Contributors: Raghav Sundar; Chia DKA; Zhao JJ; Lee ARYB; Kim G; Tan HL; Pang A; Shabbir A; Willaert W; Ma H et al.
Source: Self-asserted source
Kie Kyon Huang

Integrated enhancer regulatory network by enhancer-promoter looping in gastric cancer.

NAR cancer
2024-05-08 | Journal article
Contributors: Zhu T; Okabe A; Usui G; Fujiki R; Komiyama D; Huang KK; Seki M; Fukuyo M; Abe H; Ning M et al.
Source: Self-asserted source
Kie Kyon Huang

Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression

Cancer Cell
2023-12 | Journal article
Contributors: Kie Kyon Huang; Haoran Ma; Roxanne Hui Heng Chong; Tomoyuki Uchihara; Benedict Shi Xiang Lian; Feng Zhu; Taotao Sheng; Supriya Srivastava; Su Ting Tay; Raghav Sundar et al.
Source: check_circle
Crossref

Integrated environmental, lifestyle, and epigenetic risk prediction of primary gastric neoplasia using the longitudinally monitored cohorts

eBioMedicine
2023-10-26 | Journal article
Part of ISSN: 2352-3964
Contributors: Genki Usui; Keisuke Matsusaka; Kie Kyon Huang; Feng Zhu; Tomohiro Shinozaki; Masaki Fukuyo; Bahityar Rahmutulla; Norikazu Yogi; Tomoka Okada; Mizuki Minami et al.
Source: Self-asserted source
Kie Kyon Huang

Comprehensive molecular phenotyping ofARID1A-deficient gastric cancer reveals pervasive epigenomic reprogramming and therapeutic opportunities

Gut
2023-09 | Journal article
Contributors: Chang Xu; Kie Kyon Huang; Jia Hao Law; Joy Shijia Chua; Taotao Sheng; Natasha M Flores; Melissa Pool Pizzi; Atsushi Okabe; Angie Lay Keng Tan; Feng Zhu et al.
Source: check_circle
Crossref

Regulatory enhancer profiling of mesenchymal-type gastric cancer reveals subtype-specific epigenomic landscapes and targetable vulnerabilities

Gut
2023-02 | Journal article
Contributors: Shamaine Wei Ting Ho; Taotao Sheng; Manjie Xing; Wen Fong Ooi; Chang Xu; Raghav Sundar; Kie Kyon Huang; Zhimei Li; Vikrant Kumar; Kalpana Ramnarayanan et al.
Source: check_circle
Crossref

Chromatin Rewiring by Mismatch Repair Protein MSH2 Alters Cell Adhesion Pathways and Sensitivity to BET Inhibition in Gastric Cancer.

Cancer research
2022-07-01 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Single-Cell Atlas of Lineage States, Tumor Microenvironment, and Subtype-Specific Expression Programs in Gastric Cancer.

Cancer discovery
2022-03-01 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer.

Genome medicine
2021-10-11 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Epigenetic promoter alterations in GI tumour immune-editing and resistance to immune checkpoint inhibition.

Gut
2021-08-25 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang
grade
Preferred source (of 2)‎

Highly recurrent CBS epimutations in gastric cancer CpG island methylator phenotypes and inflammation.

Genome biology
2021-06-01 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

CRISPRi enables isoform-specific loss-of-function screens and identification of gastric cancer-specific isoform dependencies.

Genome biology
2021-01-26 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Long-read transcriptome sequencing reveals abundant promoter diversity in distinct molecular subtypes of gastric cancer.

Genome biology
2021-01-22 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma.

Nature genetics
2020-07-27 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Genomic and epigenomic EBF1 alterations modulate TERT expression in gastric cancer.

The Journal of clinical investigation
2020-06-01 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

An LCM-based genomic analysis of SPEM, Gastric Cancer and Pyloric Gland Adenoma in an Asian cohort.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
2020-04-08 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

DNA damage signalling as an anti-cancer barrier in gastric intestinal metaplasia.

Gut
2020-01-14 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

<i>HNF4α</i> pathway mapping identifies wild-type <i>IDH1</i> as a targetable metabolic node in gastric cancer.

Gut
2019-05-08 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Epigenomic promoter alterations predict for benefit from immune checkpoint inhibition in metastatic gastric cancer.

Annals of oncology : official journal of the European Society for Medical Oncology
2019-03-01 | Journal article
Contributors: Raghav Sundar; Huang KK; Qamra A; Kim KM; Kim ST; Kang WK; Tan ALK; Lee J; Tan P
Source: Self-asserted source
Kie Kyon Huang

Genomic and Epigenomic Profiling of High-Risk Intestinal Metaplasia Reveals Molecular Determinants of Progression to Gastric Cancer.

Cancer cell
2017-12-28 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Acquired Resistance to FGFR Inhibitor in Diffuse-Type Gastric Cancer through an AKT-Independent PKC-Mediated Phosphorylation of GSK3β.

Molecular cancer therapeutics
2017-10-04 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells.

Gastroenterology
2017-04-05 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck.

Scientific reports
2016-01-21 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.

Genome medicine
2015-09-23 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

SETD2 histone modifier loss in aggressive GI stromal tumours.

Gut
2015-09-03 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang

Genome-wide mutational signatures of aristolochic acid and its application as a screening tool.

Science translational medicine
2013-08-01 | Journal article
Contributors: Kie Kyon Huang
Source: Self-asserted source
Kie Kyon Huang