Personal information

Keywords

cell signalling, Ribosome biogenesis, Cancer, drug development, RNA polymerase I transcription

Countries

Australia

Activities

Collapse all

Employment (4)

Australian National University: Canberra, ACT, AU

2015-05-01 to present | Senior Research Fellow Level C (ACRF Cancer Biology and Therapeutics)
Employment
Source: Self-asserted source
Katherine Hannan

Peter MacCallum Cancer Centre: VIC, VIC, AU

2002-05-01 to 2015-05-01 | Senior Research Officer (Oncogenic Siganlling Lab)
Employment
Source: Self-asserted source
Katherine Hannan

Peter MacCallum Cancer Centre: VIC, VIC, AU

1999-05-01 to 2002-05-01 | Research Officer (Protein Chemsitry Lab)
Employment
Source: Self-asserted source
Katherine Hannan

Baker IDI Heart and Diabetes Institute: Melbourne, VIC, AU

1998-05-01 to 1999-05-01 | Research Officer (Cell Biology of Diabetes)
Employment
Source: Self-asserted source
Katherine Hannan

Education and qualifications (2)

Pennsylvania State University: University Park, PA, US

1991-05-01 to 1992-05-01 | doctorate (Cell and Molecular Physiology)
Education
Source: Self-asserted source
Katherine Hannan

University of Tasmania: Hobart, TAS, AU

1986-02-01 to 1990-12-01 | BSc (hons) (biochemistry)
Education
Source: Self-asserted source
Katherine Hannan

Works (50 of 55)

Items per page:
Page 1 of 2

A functional genetic screen defines the AKT-induced senescence signaling network

Cell death and differentiation
2020 | Journal article
DOI: 10.1038/s41418-019-0384-8
Source: Self-asserted source
Katherine Hannan

A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Oncogene
2019 | Journal article
DOI: 10.1038/s41388-018-0666-5
Source: Self-asserted source
Katherine Hannan

Inhibition of RNA Polymerase I Transcription Activates Targeted DNA Damage Response and Enhances the Efficacy of PARP Inhibitors in High-Grade Serous Ovarian Cancer

2019 | Other
DOI: 10.1101/621623
Source: Self-asserted source
Katherine Hannan

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

2019 | Other
DOI: 10.1101/737718
Source: Self-asserted source
Katherine Hannan

Reprogrammed mRNA translation drives metabolic response to therapeutic targeting of ribosome biogenesis

2019 | Other
DOI: 10.1101/847723
Source: Self-asserted source
Katherine Hannan

Targeting RNA Polymerase I transcription synergises with TOP1 inhibition in potentiating the DNA damage response in high-grade serous ovarian cancer

2019 | Other
DOI: 10.1101/849307
Source: Self-asserted source
Katherine Hannan

The long noncoding RNA lncNB1 promotes tumorigenesis by interacting with ribosomal protein RPL35

Nature communications
2019 | Journal article
DOI: 10.1038/s41467-019-12971-3
Source: Self-asserted source
Katherine Hannan

High-Content Imaging Approaches to Quantitate Stress-Induced Changes in Nucleolar Morphology

Assay and drug development technologies
2018 | Journal article
DOI: 10.1089/adt.2018.861
Source: Self-asserted source
Katherine Hannan

New Roles for the Nucleolus in Health and Disease

BioEssays : news and reviews in molecular, cellular and developmental biology
2018 | Journal article
DOI: 10.1002/bies.201700233
Source: Self-asserted source
Katherine Hannan

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Gene
2017 | Journal article
DOI: 10.1016/j.gene.2016.12.015
Source: Self-asserted source
Katherine Hannan

Inhibition of Pol I Transcription a New Chance in the Fight Against Cancer

Technology in cancer research & treatment
2017 | Journal article
DOI: 10.1177/1533034617744955
Source: Self-asserted source
Katherine Hannan

Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population

Blood
2017 | Journal article
DOI: 10.1182/blood-2016-05-718171
Source: Self-asserted source
Katherine Hannan

Selective inhibition of RNA polymerase I transcription as a potential approach to treat African trypanosomiasis

PLoS neglected tropical diseases
2017 | Journal article
DOI: 10.1371/journal.pntd.0005432
Source: Self-asserted source
Katherine Hannan

The Potential of Targeting Ribosome Biogenesis in High-Grade Serous Ovarian Cancer

International journal of molecular sciences
2017 | Journal article
DOI: 10.3390/ijms18010210
Source: Self-asserted source
Katherine Hannan

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Oncotarget
2016 | Journal article
DOI: 10.18632/oncotarget.10346
Source: Self-asserted source
Katherine Hannan

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma

Cancer discovery
2016 | Journal article
DOI: 10.1158/2159-8290.cd-14-0673
Source: Self-asserted source
Katherine Hannan

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence

Assay and drug development technologies
2016 | Journal article
DOI: 10.1089/adt.2016.739
Source: Self-asserted source
Katherine Hannan

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Oncotarget
2016 | Journal article
DOI: 10.18632/oncotarget.10452
Source: Self-asserted source
Katherine Hannan

Regulation of rDNA transcription in response to growth factors, nutrients and energy

Gene
2015 | Journal article
DOI: 10.1016/j.gene.2014.11.010
Source: Self-asserted source
Katherine Hannan

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

Cellular signalling
2015 | Journal article
DOI: 10.1016/j.cellsig.2015.07.018
Source: Self-asserted source
Katherine Hannan

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy

Biochimica et biophysica acta
2015 | Journal article
DOI: 10.1016/j.bbagrm.2014.10.007
Source: Self-asserted source
Katherine Hannan

Targeting the nucleolus for cancer intervention

Biochimica et biophysica acta
2014 | Journal article
DOI: 10.1016/j.bbadis.2013.12.009
Source: Self-asserted source
Katherine Hannan

AKT signalling is required for ribosomal RNA synthesis and progression of Eμ-Myc B-cell lymphoma in vivo

The FEBS journal
2013 | Journal article
DOI: 10.1111/febs.12135
Source: Self-asserted source
Katherine Hannan

Autophagy induction is a Tor- and Tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis

PLoS genetics
2013 | Journal article
DOI: 10.1371/journal.pgen.1003279
Source: Self-asserted source
Katherine Hannan

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Blood
2013 | Journal article
DOI: 10.1182/blood-2012-08-446096
Source: Self-asserted source
Katherine Hannan

Dysregulation of RNA polymerase I transcription during disease

Biochimica et biophysica acta
2013 | Journal article
DOI: 10.1016/j.bbagrm.2012.10.014
Source: Self-asserted source
Katherine Hannan

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

European journal of cancer (Oxford, England : 1990)
2013 | Journal article
DOI: 10.1016/j.ejca.2013.08.007
Source: Self-asserted source
Katherine Hannan

The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence

Cancer discovery
2013 | Journal article
DOI: 10.1158/2159-8290.CD-12-0404
Source: Self-asserted source
Katherine Hannan

The nucleolus: an emerging target for cancer therapy

Trends in molecular medicine
2013 | Journal article
DOI: 10.1016/j.molmed.2013.07.005
Source: Self-asserted source
Katherine Hannan

AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy

Oncogene
2012 | Journal article
DOI: 10.1038/onc.2011.394
Source: Self-asserted source
Katherine Hannan

Too much or too little: harnessing senescence to control oncogene-driven cancer

Cell cycle (Georgetown, Tex.)
2012 | Journal article
DOI: 10.4161/cc.21588
Source: Self-asserted source
Katherine Hannan

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Cellular signalling
2011 | Journal article
DOI: 10.1016/j.cellsig.2011.03.016
Source: Self-asserted source
Katherine Hannan

AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer

Science signaling
2011 | Journal article
DOI: 10.1126/scisignal.2001754
Source: Self-asserted source
Katherine Hannan

Determination of the exact molecular requirements for type 1 angiotensin receptor epidermal growth factor receptor transactivation and cardiomyocyte hypertrophy

Hypertension (Dallas, Tex. : 1979)
2011 | Journal article
DOI: 10.1161/hypertensionaha.110.166710
Source: Self-asserted source
Katherine Hannan

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

Enzyme research
2011 | Journal article
DOI: 10.4061/2011/720985
Source: Self-asserted source
Katherine Hannan

Signaling to the ribosome in cancer--It is more than just mTORC1

IUBMB life
2011 | Journal article
DOI: 10.1002/iub.428
Source: Self-asserted source
Katherine Hannan

Phosphorylation regulates copper-responsive trafficking of the Menkes copper transporting P-type ATPase

The international journal of biochemistry & cell biology
2009 | Journal article
DOI: 10.1016/j.biocel.2009.06.008
Source: Self-asserted source
Katherine Hannan

Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation

Blood
2008 | Journal article
DOI: 10.1182/blood-2007-09-111856
Source: Self-asserted source
Katherine Hannan

UBF levels determine the number of active ribosomal RNA genes in mammals

The Journal of cell biology
2008 | Journal article
DOI: 10.1083/jcb.200805146
Source: Self-asserted source
Katherine Hannan

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

Growth factors (Chur, Switzerland)
2007 | Journal article
DOI: 10.1080/08977190701779101
Source: Self-asserted source
Katherine Hannan

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G(2)-M phase transition

Cancer research
2006 | Journal article
DOI: 10.1158/0008-5472.can-06-1968
Source: Self-asserted source
Katherine Hannan

MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

The EMBO journal
2004 | Journal article
DOI: 10.1038/sj.emboj.7600335
Source: Self-asserted source
Katherine Hannan

Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex

The Biochemical journal
2003 | Journal article
DOI: 10.1042/BJ20021709
Source: Self-asserted source
Katherine Hannan

mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF

Molecular and cellular biology
2003 | Journal article
DOI: 10.1128/MCB.23.23.8862-8877.2003
Source: Self-asserted source
Katherine Hannan

Protein kinase-dependent phosphorylation of the Menkes copper P-type ATPase

Biochemical and biophysical research communications
2003 | Journal article
DOI: 10.1016/s0006-291x(03)00329-2
Source: Self-asserted source
Katherine Hannan

Troglitazone stimulates repair of the endothelium and inhibits neointimal formation in denuded rat aorta

Arteriosclerosis, thrombosis, and vascular biology
2003 | Journal article
DOI: 10.1161/01.atv.0000069210.46539.0d
Source: Self-asserted source
Katherine Hannan

Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase

The Journal of biological chemistry
2002 | Journal article
DOI: 10.1074/jbc.m203387200
Source: Self-asserted source
Katherine Hannan

Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling

FEBS letters
2002 | Journal article
DOI: 10.1016/s0014-5793(02)02738-2
Source: Self-asserted source
Katherine Hannan

Troglitazone, but not rosiglitazone, inhibits Na/H exchange activity and proliferation of macrovascular endothelial cells

Journal of diabetes and its complications
2001 | Journal article
DOI: 10.1016/s1056-8727(01)00141-6
Source: Self-asserted source
Katherine Hannan

Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition

Circulation research
2000 | Journal article
DOI: 10.1161/01.res.87.12.1133
Source: Self-asserted source
Katherine Hannan
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Apoptosis (1)
How many people are using ORCID?