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Activities

Employment (7)

University of Pittsburgh: Pittsburgh, PA, US

2024-01-01 to present | Assistant Professor of Medicine (Medicine)
Employment
Source: Self-asserted source
Isin Cakir

University of Michigan–Ann Arbor: Ann Arbor, US

2024-01-01 to present | Adjunct Assistant Research Professor (Life Sciences Institute)
Employment
Source: Self-asserted source
Isin Cakir

University of Michigan: Ann Arbor, MI, US

2021-09-01 to 2023-12-31 | Assistant Research Scientist (Life Sciences Institute)
Employment
Source: Self-asserted source
Isin Cakir

University of Michigan: Ann Arbor, MI, US

2017-02-01 to 2021-08-31 | Research Investigator (Life Sciences Institute)
Employment
Source: Self-asserted source
Isin Cakir

Vanderbilt University: Nashville, TN, US

2015-02 to 2017-02 | Postdoctoral Fellow (Molecular Physiology and Biophysics)
Employment
Source: Self-asserted source
Isin Cakir

Children's Hospital Boston: Boston, MA, US

2010-10 to 2015-02 | Postdoctoral Fellow (Medicine/Endocrinology)
Employment
Source: Self-asserted source
Isin Cakir

Harvard Medical School: Boston, MA, US

2009-10 to 2010-10 | Postdoctoral Fellow (Pathology)
Employment
Source: Self-asserted source
Isin Cakir

Education and qualifications (3)

Brown University: Providence, RI, US

2003 to 2009 | PhD (Molecular Biology, Cell Biology and Biochemistry)
Education
Source: Self-asserted source
Isin Cakir

Boğaziçi Üniversitesi: Istanbul, TR

1998 to 2003 | BS (Molecular Biology and Genetics)
Education
Source: Self-asserted source
Isin Cakir

Boğaziçi Üniversitesi: Istanbul, TR

1998 to 2003 | BS (Chemistry)
Education
Source: Self-asserted source
Isin Cakir

Funding (6)

Peripheral histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity

2021-07-01 to 2025-06-30 | Grant
American Diabetes Association (Alexandria, US)
GRANT_NUMBER: 7-21-JDF-032
Source: Self-asserted source
Isin Cakir via DimensionsWizard

Development of HDAC6 inhibitors as novel anti-obesity agents

2018-08 to 2019-12 | Grant
Michigan Drug Discovery (Ann Arbor, MI, US)
Source: Self-asserted source
Isin Cakir

Reversal of diet-induced obesity with histone deacetylase 6 inhibitors

2018-02 to 2018-12 | Grant
University of Michigan (MI, MI, US)
Source: Self-asserted source
Isin Cakir

Searching for Sensitizers of Leptin Receptor Signaling

2017-10 to 2018-02 | Grant
Vanderbilt University (TN, TN, US)
Source: Self-asserted source
Isin Cakir

Anti-obesity and anti-diabetic interventions by small molecule compounds

2017-01-15 to 2020-08-15 | Grant
Qatar National Research Fund (Doha, QA)
GRANT_NUMBER: NPRP9-351-3-075
Source: Self-asserted source
Isin Cakir via DimensionsWizard

Role of HDAC6 in the Regulation of Energy Homeostasis and Leptin Sensitivity

Grant
National Institute of Diabetes and Digestive and Kidney Diseases (Bethesda, US)
Source: Self-asserted source
Isin Cakir

Works (19)

AI is a viable alternative to high throughput screening: a 318-target study.

Scientific reports
2024-04-02 | Journal article
Contributors: Atomwise AIMS Program
Source: Self-asserted source
Isin Cakir

Sulforaphane reduces obesity by reversing leptin resistance

eLife
2022-03-24 | Journal article
Contributors: Işın Çakır; Pauline Lining Pan; Colleen K Hadley; Abdulrahman El-Gamal; Amina Fadel; Dina Elsayegh; Omnia Mohamed; Nasser M Rizk; Masoud Ghamari-Langroudi
Source: check_circle
Crossref

Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity

Nature Metabolism
2022-01-17 | Journal article
Contributors: Işın Çakır; Colleen K. Hadley; Pauline Lining Pan; Rushita A. Bagchi; Masoud Ghamari-Langroudi; Danielle T. Porter; Qiuyu Wang; Michael J. Litt; Somnath Jana; Susan Hagen et al.
Source: check_circle
Crossref

Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis

Proceedings of the National Academy of Sciences
2021-10-19 | Journal article
Contributors: Yu Yong; Isin Cakir; Pauline Lining Pan; Jessica E. Biddinger; Rebecca J. Bluett; Ken Mackie; Nathan Bingham; Sachin Patel; Masoud Ghamari-Langroudi
Source: check_circle
Crossref

Deletion of the Feeding-Induced Hepatokine TSK Ameliorates the Melanocortin Obesity Syndrome.

Diabetes
2021-06-28 | Journal article
Contributors: Wang Q; Zhang P; Cakir I; Mi L; Cone RD; Jiandie Lin
Source: Self-asserted source
Isin Cakir

Leptin resensitisation: a reversion of leptin-resistant states.

The Journal of endocrinology
2019-06-01 | Journal article
Source: Self-asserted source
Isin Cakir

Leptin Receptor Signaling in Sim1-Expressing Neurons Regulates Body Temperature and Adaptive Thermogenesis.

Endocrinology
2019-04-01 | Journal article
Source: Self-asserted source
Isin Cakir

Endoplasmic Reticulum Stress, the Hypothalamus, and Energy Balance.

Trends in endocrinology and metabolism: TEM
2019-01-25 | Journal article
Source: Self-asserted source
Isin Cakir

Late onset obesity in mice with targeted deletion of potassium inward rectifier Kir7.1 from cells expressing the melanocortin-4 receptor.

Journal of neuroendocrinology
2019-01-20 | Journal article
Source: Self-asserted source
Isin Cakir

Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function

Source: Self-asserted source
Isin Cakir

Regulation of energy rheostasis by the melanocortin-3 receptor

Science Advances
2018-08-03 | Journal article
Contributors: Masoud Ghamari-Langroudi; Isin Cakir; Rachel N. Lippert; Patrick Sweeney; Michael J. Litt; Kate L. J. Ellacott; Roger D. Cone
Source: check_circle
Crossref

Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy.

eLife
2017-08-22 | Journal article
Source: Self-asserted source
Isin Cakir

60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.

Journal of molecular endocrinology
2016-03-03 | Journal article
Source: Self-asserted source
Isin Cakir

BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K.

Cell metabolism
2014-05-15 | Journal article
Contributors: Park SW; Hilde Herrema; Salazar M; Cakir I; Cabi S; Basibuyuk Sahin F; Chiu YH; Cantley LC; Ozcan U
Source: Self-asserted source
Isin Cakir

Mom's milk molds neural wiring for metabolism.

Cell
2014-01-01 | Journal article
Contributors: Cakir I; Ozcan U
Source: Self-asserted source
Isin Cakir

Obesity induces hypothalamic endoplasmic reticulum stress and impairs proopiomelanocortin (POMC) post-translational processing.

The Journal of biological chemistry
2013-05-02 | Journal article
Source: Self-asserted source
Isin Cakir

Maintenance of the thyroid axis during diet-induced obesity in rodents is controlled at the central level.

American journal of physiology. Endocrinology and metabolism
2010-09-21 | Journal article
Source: Self-asserted source
Isin Cakir

Hypothalamic Sirt1 regulates food intake in a rodent model system.

PloS one
2009-12-15 | Journal article
Source: Self-asserted source
Isin Cakir

Role of a pro-sequence in the secretory pathway of prothyrotropin-releasing hormone.

The Journal of biological chemistry
2008-09-08 | Journal article
Source: Self-asserted source
Isin Cakir