Personal information

Emails & domains

Verified email domains

Activities

Collapse all

Employment (4)

Cardiff University: Cardiff, South Glamorgan, GB

2017-11-01 to present | Principle Investigator (School of Medicine)
Employment
Source: Self-asserted source
Gaynor Smith

Oregon Health and Science University: Portland, OR, US

2016 to 2017 | Post doctoral fellow (The Vollum Insitute)
Employment
Source: Self-asserted source
Gaynor Smith

UMass Memorial Medical Center Memorial Campus: Worcester, MA, US

2014 to 2016 | post doc (Neurobiology)
Employment
Source: Self-asserted source
Gaynor Smith

Harvard Medical School: Boston, MA, US

2011 to 2014 | post doc (Neuroregeneration Laboratories)
Employment
Source: Self-asserted source
Gaynor Smith

Education and qualifications (2)

Cardiff University: Cardiff, Cardiff, GB

2007 to 2011 | Ph.D (Bioscience)
Education
Source: Self-asserted source
Gaynor Smith

Cardiff University: Cardiff, Cardiff, GB

2004 to 2007 | BSc (hons) (Bioscience)
Education
Source: Self-asserted source
Gaynor Smith

Funding (2)

Momentum

Award
Medical Research Council (Cardiff, GB)
Source: Self-asserted source
Gaynor Smith

Understanding Mitochondrial Dynamics in Axons

Grant
National Institutes of Health (MD, MD, US)
Source: Self-asserted source
Gaynor Smith

Works (26)

Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation

2019-05 | Journal article
DOI: 10.1016/j.neuron.2019.04.017
Part of ISSN: 0896-6273
Source: Self-asserted source
Gaynor Smith

Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease.

Brain, behavior, and immunity
2017-03 | Journal article
DOI: 10.1016/j.bbi.2016.11.014
PMID: 27864045
PMC: PMC5325122
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition.

Molecular neurobiology
2016-10 | Journal article
DOI: 10.1007/s12035-015-9435-4
PMID: 26399642
PMC: PMC5012155
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Using Drosophila models of Huntington's disease as a translatable tool.

Journal of neuroscience methods
2016-05 | Journal article
DOI: 10.1016/j.jneumeth.2015.07.026
PMID: 26241927
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

A Nurr1 agonist causes neuroprotection in a Parkinson's disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C).

PloS one
2015 | Journal article
DOI: 10.1371/journal.pone.0121072
PMID: 25815475
PMC: PMC4376720
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons.

Neurobiology of disease
2015-10 | Journal article
DOI: 10.1016/j.nbd.2015.09.009
PMID: 26392287
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice.

Antioxidants & redox signaling
2015-08 | Journal article
DOI: 10.1089/ars.2015.6307
PMID: 26094487
PMC: PMC4544823
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Progressive decline of glucocerebrosidase in aging and Parkinson's disease.

Annals of clinical and translational neurology
2015-04 | Journal article
DOI: 10.1002/acn3.177
PMID: 25909088
PMC: PMC4402088
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Successful function of autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease.

Cell stem cell
2015-03 | Journal article
DOI: 10.1016/j.stem.2015.01.018
PMID: 25732245
PMC: PMC4462124
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress.

Experimental neurology
2014-11 | Journal article
DOI: 10.1016/j.expneurol.2014.05.024
PMID: 24907400
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.

Human molecular genetics
2014-09 | Journal article
DOI: 10.1093/hmg/ddu166
PMID: 24728190
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection.

Neuroscience letters
2014-07 | Journal article
DOI: 10.1016/j.neulet.2014.05.044
PMID: 24882721
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease.

Neurobiology of disease
2014-04 | Journal article
DOI: 10.1016/j.nbd.2013.12.011
PMID: 24388974
PMC: PMC3988924
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Chronic administration of Dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice.

Journal of Alzheimer's disease : JAD
2013 | Journal article
DOI: 10.3233/jad-130071
PMID: 23645096
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Two cells are better than one: optimizing stem cell survival by co-grafting "helper" cells that offer regulated trophic support.

Experimental neurology
2013-09 | Journal article
DOI: 10.1016/j.expneurol.2013.07.003
PMID: 23856435
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons.

Stem cells (Dayton, Ohio)
2013-08 | Journal article
DOI: 10.1002/stem.1415
PMID: 23666606
PMC: PMC3775937
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice.

The European journal of neuroscience
2013-01 | Journal article
DOI: 10.1111/ejn.12036
PMID: 23113688
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Amphetamine-induced dyskinesia in the transplanted hemi-Parkinsonian mouse.

Journal of Parkinson's disease
2012 | Journal article
DOI: 10.3233/jpd-2012-12102
PMID: 23933747
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats.

Neuropharmacology
2012-10 | Journal article
DOI: 10.1016/j.neuropharm.2012.06.011
PMID: 22722025
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

The search for genetic mouse models of prodromal Parkinson's disease.

Experimental neurology
2012-10 | Journal article
DOI: 10.1016/j.expneurol.2012.06.035
PMID: 22819262
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat--response to pharmacological modulation.

Behavioural brain research
2012-07 | Journal article
DOI: 10.1016/j.bbr.2012.04.003
PMID: 22516841
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: motor impairments identify extent of dopamine depletion at three different lesion sites.

Behavioural brain research
2012-03 | Journal article
DOI: 10.1016/j.bbr.2011.11.027
PMID: 22146593
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: predicting l-DOPA-induced dyskinesia.

Behavioural brain research
2012-01 | Journal article
DOI: 10.1016/j.bbr.2011.09.025
PMID: 21946310
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates.

Journal of neuroscience methods
2011-08 | Journal article
DOI: 10.1016/j.jneumeth.2011.06.012
PMID: 21723319
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Context-driven changes in L-DOPA-induced behaviours in the 6-OHDA lesioned rat.

Neurobiology of disease
2011-04 | Journal article
DOI: 10.1016/j.nbd.2011.01.010
PMID: 21220017
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Understanding graft-induced dyskinesia.

Regenerative medicine
2010-09 | Journal article
DOI: 10.2217/rme.10.42
PMID: 20868333
Source: Self-asserted source
Gaynor Smith via Europe PubMed Central

Peer review (4 reviews for 3 publications/grants)

Review activity for Acta neuropathologica communications. (1)
Review activity for Cell reports. (2)
Review activity for Experimental neurology. (1)
How many people are using ORCID?