Personal information

Germany

Activities

Employment (3)

Universitätsklinikum Münster: Munster, Nordrhein-Westfalen, DE

2022 to present (General Pediatrics)
Employment
Source: Self-asserted source
Alexander Siegfried Busch

Rigshospitalet: Kobenhavn, DK

2015 to 2021
Employment
Source: Self-asserted source
Alexander Siegfried Busch

MRC Epidemiology Unit : Cambridge, Cambridgeshire, GB

2018 to 2018 | Visiting Researcher
Employment
Source: Self-asserted source
Alexander Siegfried Busch

Works (47)

Serum DLK1 During Minipuberty and Pubertal Transition in Healthy Girls and in Girls with Precocious Puberty

The Journal of Clinical Endocrinology & Metabolism
2024-10-28 | Journal article
Part of ISSN: 0021-972X
Part of ISSN: 1945-7197
Contributors: Lea Vilmann; Kaspar Sørensen; Alexander S Busch; Marie L Ljubicic; Emmie N Upners; Margit B Fischer; Trine H Johannsen; Stine A Holmboe; Anders Juul; Casper P Hagen
Source: Self-asserted source
Alexander Siegfried Busch

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Nature Genetics
2024-07-01 | Journal article
Part of ISSN: 1061-4036
Part of ISSN: 1546-1718
Contributors: Katherine A. Kentistou; Lena Kaisinger; Stasa Stankovic; Marc Vaudel; Edson Mendes de Oliveira; Andrea Messina; Robin Walters; Xiaoxi Liu; Alexander S. Busch; Hannes Helgason et al.
Source: Self-asserted source
Alexander Siegfried Busch

Serum Concentrations of Inhibin B in Healthy Females and Males Throughout Life.

The Journal of clinical endocrinology and metabolism
2024-06-26 | Journal article | Author
Contributors: Borelli-Kjær A; Lise Aksglaede; Rikke Beck Jensen; Casper Hagen; Marie Lindhardt Ljubicic; Alexander Siegfried Busch; Emmie Nicolina Upners; MB Fischer; Tina Kold Jensen; Linneberg A et al.
Source: Self-asserted source
Alexander Siegfried Busch

Polygenic Scores for Adult Testosterone and SHBG Levels Are Associated With Reproductive Hormone Levels in Male Infants.

The Journal of clinical endocrinology and metabolism
2024-02-27 | Journal article | Author
Contributors: Alexander Siegfried Busch; Ljubicic ML; Upners EN; Fischer MB; Odroniec A; Casper Hagen; Anders Juul
Source: Self-asserted source
Alexander Siegfried Busch

Male minipuberty in human and non-human primates: planting the seeds of future fertility.

Reproduction (Cambridge, England)
2023-09-04 | Journal article | Author
Contributors: Alexander Siegfried Busch; Paturlanne JM; Nina Neuhaus; Wistuba J; Schlatt S; Anders Juul; Omran H
Source: Self-asserted source
Alexander Siegfried Busch

Bi-allelic variants in INSL3 and RXFP2 cause bilateral cryptorchidism and male infertility.

Human reproduction (Oxford, England)
2023-07-01 | Journal article
Contributors: Ann-Kristin Dicke; Jakob Albrethsen; Bradley Hoare; Margot J. Wyrwoll; Busch AS; Fietz D; Adrian Pilatz; Bühlmann C; Anders Juul; Kliesch S et al.
Source: Self-asserted source
Alexander Siegfried Busch

Urinary concentration of phthalates and bisphenol A during minipuberty is associated with reproductive hormone concentrations in infant boys

International Journal of Hygiene and Environmental Health
2023-05 | Journal article
Part of ISSN: 1438-4639
Contributors: Lærkeholm Müller; Alexander Siegfried Busch; Marie Lindhardt Ljubicic; Emmie N. Upners; Margit B. Fischer; Casper P. Hagen; Jakob Albrethsen; Hanne Frederiksen; Anders Juul; Anna-Maria Andersson
Source: Self-asserted source
Alexander Siegfried Busch

AMH concentrations in infancy and mid-childhood predict ovarian activity in adolescence: A long-term longitudinal study of healthy girls

eClinicalMedicine
2023-01 | Journal article | Author
Part of ISSN: 2589-5370
Contributors: Casper P. Hagen; Margit Bistrup Fischer; Christine Wohlfahrt-Veje; Maria Assens; Alexander Siegfried Busch; Anette Tønnes Pedersen; Anders Juul; Katharina Maria Main
Source: Self-asserted source
Alexander Siegfried Busch

Serum LH/FSH ratios in 87 infants with differences of sex development

Endocrine Connections
2023-01-25 | Journal article
Part of ISSN: 2049-3614
Contributors: Marie Lindhardt Ljubicic; Trine Holm Johannsen; Margit Bistrup Fischer; Emmie N Upners; Alexander S Busch; Katharina M Main; Anna-Maria Andersson; Casper P Hagen; Anders Juul
Source: Self-asserted source
Alexander Siegfried Busch

Longitudinal evaluation of breast tissue in healthy infants: Prevalence and relation to reproductive hormones and growth factors

Frontiers in Endocrinology
2022-12-01 | Journal article
Part of ISSN: 1664-2392
Contributors: Marie Lindhardt Ljubicic; Andre Madsen; Emmie N. Upners; Margit Bistrup Fischer; Alexander Siegfried Busch; Hanne Frederiksen; Trine Holm Johannsen; Anders Juul; Casper P. Hagen
Source: Self-asserted source
Alexander Siegfried Busch

Benzophenones, bisphenols and other polychlorinated/phenolic substances in Danish infants and their parents - including longitudinal assessments before and after introduction to mixed diet

Environment International
2022-09 | Journal article
Part of ISSN: 0160-4120
Contributors: Alexander Siegfried Busch
Source: Self-asserted source
Alexander Siegfried Busch

A Biphasic Pattern of Reproductive Hormones in Healthy Female Infants –The COPENHAGEN Minipuberty Study

The Journal of Clinical Endocrinology & Metabolism
2022-06-15 | Journal article
Part of ISSN: 0021-972X
Part of ISSN: 1945-7197
Source: Self-asserted source
Alexander Siegfried Busch

Dynamic Changes in LH/FSH Ratios in Infants with Normal Sex Development

European Journal of Endocrinology
2022-05 | Journal article
Part of ISSN: 0804-4643
Part of ISSN: 1479-683X
Source: Self-asserted source
Alexander Siegfried Busch

Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity.

The Journal of clinical endocrinology and metabolism
2022-02-28 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Exposure to 15 phthalates and two substitutes (DEHTP and DINCH) assessed in trios of infants and their parents as well as longitudinally in infants exclusively breastfed and after the introduction of a mixed diet.

Environment international
2022-01-25 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Dynamic Changes in Serum IGF-I and Growth During Infancy: Associations to Body Fat, Target Height and PAPPA2 Genotype.

The Journal of clinical endocrinology and metabolism
2021-09-03 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Cohort profile: The COPENHAGEN Minipuberty Study-A longitudinal prospective cohort of healthy full-term infants and their parents.

Paediatric and perinatal epidemiology
2021-06-22 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Total and central adiposity are associated with age at gonadarche and incidence of precocious gonadarche in boys.

The Journal of clinical endocrinology and metabolism
2021-02-04 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Does height and IGF-I determine pubertal timing in girls?

Pediatric research
2020-11-03 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Marked Increase in Incident Gynecomastia: A 20-Year National Registry Study, 1998 to 2017.

The Journal of clinical endocrinology and metabolism
2020-10-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Trends in the Incidence of Central Precocious Puberty and Normal Variant Puberty Among Children in Denmark, 1998 to 2017.

JAMA network open
2020-10-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Anogenital Distance in Healthy Infants: Method-, Age- and Sex-related Reference Ranges.

The Journal of clinical endocrinology and metabolism
2020-09-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Reproductive hormones during pubertal transition in girls with transient Thelarche.

Clinical endocrinology
2020-06-11 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls: A Systematic Review and Meta-analysis.

JAMA pediatrics
2020-04-06 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Heritability of pubertal timing: detailed evaluation of specific milestones in healthy boys and girls.

European journal of endocrinology
2020-04-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Obesity Is Associated with Earlier Pubertal Onset in Boys.

The Journal of clinical endocrinology and metabolism
2020-04-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan.

Nature communications
2020-03-24 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

A Polygenic Risk Score Suggests Shared Genetic Architecture of Voice Break With Early Markers of Pubertal Onset in Boys.

The Journal of clinical endocrinology and metabolism
2020-03-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

The External Genitalia Score (EGS): A European Multicenter Validation Study.

The Journal of clinical endocrinology and metabolism
2020-03-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Using human genetics to understand the disease impacts of testosterone in men and women.

Nature medicine
2020-02-10 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.

Science (New York, N.Y.)
2019-08-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Voice break in boys-temporal relations with other pubertal milestones and likely causal effects of BMI.

Human reproduction (Oxford, England)
2019-07-26 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

FSHB -211 G>T Polymorphism as Predictor for TESE Success in Patients With Unexplained Azoospermia.

The Journal of clinical endocrinology and metabolism
2019-06-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Deletion in the uridine diphosphate glucuronyltransferase 2B17 gene is associated with delayed pubarche in healthy boys.

Endocrine connections
2018-02-21 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

The AMH genotype (rs10407022 T>G) is associated with circulating AMH levels in boys, but not in girls.

Endocrine connections
2018-01-22 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Differential Impact of Genetic Loci on Age at Thelarche and Menarche in Healthy Girls.

The Journal of clinical endocrinology and metabolism
2018-01-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men.

Scientific reports
2017-12-08 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer?

Andrology
2017-11-27 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Nocturnal Urinary Excretion of FSH and LH in Children and Adolescents With Normal and Early Puberty.

The Journal of clinical endocrinology and metabolism
2017-10-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Genetic Variation of Follicle-Stimulating Hormone Action Is Associated With Age at Testicular Growth in Boys.

The Journal of clinical endocrinology and metabolism
2017-05-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Pubertal development in healthy children is mirrored by DNA methylation patterns in peripheral blood.

Scientific reports
2016-06-28 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Genetic Variations in FSH Action Affect Sex Hormone Levels and Breast Tissue Size in Infant Girls: A Pilot Study.

The Journal of clinical endocrinology and metabolism
2016-06-07 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Circulating MKRN3 Levels Decline During Puberty in Healthy Boys.

The Journal of clinical endocrinology and metabolism
2016-04-08 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Genetic variations altering FSH action affect circulating hormone levels as well as follicle growth in healthy peripubertal girls.

Human reproduction (Oxford, England)
2016-02-23 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

FSHB -211G>T stratification for follicle-stimulating hormone treatment of male infertility patients: making the case for a pharmacogenetic approach in genetic functional secondary hypogonadism.

Andrology
2015-10-07 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

The FSHB -211G>T variant attenuates serum FSH levels in the supraphysiological gonadotropin setting of Klinefelter syndrome.

European journal of human genetics : EJHG
2014-07-23 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch

Effects of the FSH-β-subunit promoter polymorphism -211G->T on the hypothalamic-pituitary-ovarian axis in normally cycling women indicate a gender-specific regulation of gonadotropin secretion.

The Journal of clinical endocrinology and metabolism
2012-11-01 | Journal article
Source: Self-asserted source
Alexander Siegfried Busch