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Polytechnic University of Madrid: Madrid, Spain, ES

2023-09-01 to present | Assistant Professor (Biotechnology)
Employment
Source: Self-asserted source
JAIME TOME-AMAT

Works (44)

A Multifunctionalized Potyvirus-Derived Nanoparticle That Targets and Internalizes into Cancer Cells

Preprints.org
2024 | Journal article
Contributors: Truchado, Daniel A.; Juarez-Molina, Maria; Rincon, Sara; Zurita, Lucia; Tome-Amat, Jaime; Lorz, Corina; Ponz, Fernando
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Author Correction: Production and use of antigen tetramers to study antigen-specific B cells

Nature Protocols
2024-12-24 | Journal article
Contributors: Allyssa Phelps; Diego Pazos-Castro; Francesca Urselli; Emily Grydziuszko; Olivia Mann-Delany; Allison Fang; Tina D. Walker; Rangana Talpe Guruge; Jaime Tome-Amat; Araceli Diaz-Perales et al.
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Virus-like Particles as Vaccines for Allergen-Specific Therapy: An Overview of Current Developments

International Journal of Molecular Sciences
2024-07-06 | Journal article
Contributors: Helena Berreiros-Hortala; Gonzalo Vilchez-Pinto; Araceli Diaz-Perales; Maria Garrido-Arandia; Jaime Tome-Amat
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Production and use of antigen tetramers to study antigen-specific B cells

Nature Protocols
2024-03 | Journal article
Contributors: Allyssa Phelps; Diego Pazos-Castro; Francesca Urselli; Emily Grydziuszko; Olivia Mann-Delany; Allison Fang; Tina D. Walker; Rangana Talpe Guruge; Jaime Tome-Amat; Araceli Diaz-Perales et al.
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Crossref

Plant lipid transfer proteins' ligand enhances allergic sensitization to non‐related proteins in murine models

Allergy
2024-01 | Journal article
Contributors: Jaime Tome‐Amat; Zulema Gonzalez‐Klein; Diego Pazos‐Castro; Jose Luis Resuela‐Gonzalez; Gonzalo Vilchez‐Pinto; Helena Berreiros‐Hortala; Lucia Palacio‐Garcia; Sergio Fernandez‐Bravo; Vanesa Esteban; Araceli Diaz‐Perales et al.
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Molecular mechanism of Alt a 1-TLR4 interaction

Allergy
2023 | Journal article
Contributors: Vilchez-Pinto, G.; Hernandez-Ramirez, G.; Pazos-Castro, D.; Gonzalez-Klein, Z.; Resuela-Gonzalez, J. L.; Tome-Amat, J.; Garrido-Arandia, M.; Diaz, A.
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Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines (vol 13, 986823.1133046, 2023)

Frontiers in Immunology
2023 | Journal article
Contributors: Pazos-Castro, Diego; Margain, Clemence; Gonzalez-Klein, Zulema; Amores-Borge, Marina; Yuste-Calvo, Carmen; Garrido-Arandia, Maria; Zurita, Lucia; Esteban, Vanesa; Tome-Amat, Jaime; Diaz-Perales, Araceli et al.
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Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients

Frontiers in Immunology
2023-10-30 | Journal article
Part of ISSN: 1664-3224
Contributors: Emilio Nuñez-Borque; Sergio Fernandez-Bravo; Pablo Rodríguez Del Rio; Lucia Palacio-García; Angela Di Giannatale; Virginia Di Paolo; Angela Galardi; Marta Colletti; Luisa Pascucci; Jaime Tome-Amat et al.
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JAIME TOME-AMAT

A New Optimized Version of a Colorectal Cancer-Targeted Immunotoxin Based on a Non-Immunogenic Variant of the Ribotoxin α-Sarcin

Cancers
2023-02-09 | Journal article
Contributors: Javier Narbona; Rubén G. Gordo; Jaime Tomé-Amat; Javier Lacadena
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NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model

Scientific Reports
2022 | Journal article
Contributors: Pazos-Castro, Diego; Gonzalez-Klein, Zulema; Yuste Montalvo, Alma; Hernandez-Ramirez, Guadalupe; Romero-Sahagun, Alejandro; Esteban, Vanesa; Garrido-Arandia, Maria; Tome-Amat, Jaime; Diaz-Perales, Araceli
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Suitability of potyviral recombinant virus-like particles bearing a complete food allergen for immunotherapy vaccines

Frontiers in Immunology
2022-09-08 | Journal article
Part of ISSN: 1664-3224
Contributors: JAIME TOME-AMAT
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JAIME TOME-AMAT
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Integration of Multiple Interferometers in Highly Multiplexed Diagnostic KITs to Evaluate Several Biomarkers of COVID-19 in Serum

Biosensors
2022-08 | Journal article | Author
Contributors: Ana María M. Murillo; L.G Valle; Yolanda Ramírez; María Jesús Sánchez; Beatriz Santamaria; E. Molina-Roldan; Isabel Ortega-Madueño; Elena Urcelay; Luca Tramarin; P. Herreros - Pedro Herreros et al.
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Multidisciplinary Digital Publishing Institute
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Antitumor Applications of Polyphenol-Conjugated Turnip Mosaic Virus-Derived Nanoparticles

Nanomedicine
2022-06 | Journal article
Contributors: Edith Velázquez-Lam; Jaime Tome-Amat; Carmen Segrelles; Carmen Yuste-Calvo; Sara Asensio; Jorge Peral; Fernando Ponz; Corina Lorz
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Alt a 1 Promotes Allergic Asthma In Vivo Through TLR4-Alveolar Macrophages

Frontiers in Immunology
2022-06-30 | Journal article
Part of ISSN: 1664-3224
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JAIME TOME-AMAT
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Lipid Ligands and Allergenic LTPs: Redefining the Paradigm of the Protein-Centered Vision in Allergy

Frontiers in Allergy
2022-05-19 | Journal article
Part of ISSN: 2673-6101
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JAIME TOME-AMAT

Identification and molecular characterization of a novel non-specific lipid transfer protein (TdLTP2) from durum wheat

PLOS ONE
2022-04-13 | Journal article
Contributors: Khawla Missaoui; Genlou Sun; Zulema Gonzalez-Klein; Sonia Jemli; Maria Garrido-Arandia; Araceli Diaz-Perales; Jaime Tome-Amat; Faiçal Brini
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Plant non-specific lipid transfer proteins: An overview

Plant Physiology and Biochemistry
2022-01 | Journal article
Contributors: Khawla Missaoui; Zulema Gonzalez-Klein; Diego Pazos-Castro; Guadalupe Hernandez-Ramirez; Maria Garrido-Arandia; Faical Brini; Araceli Diaz-Perales; Jaime Tome-Amat
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Characterization of ligands from allergenic lipid transfer proteins (ltps)

Allergy
2021 | Journal article
Contributors: Gonzalez-Klein, Z.; Cuevas-Zuviria, B.; Wangorsch, A.; Hernnandez-Ramirez, G.; Pazos-Castro, D.; Romero-Sahagun, A.; Pacios, L. F.; Tome-Amat, J.; Scheurer, S.; Diaz-Perales, A. et al.
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Developing an Optical Interferometric Detection Method based biosensor for detecting specific SARS-CoV-2 immunoglobulins in Serum and Saliva, and their corresponding ELISA correlation

Sensors and Actuators B: Chemical
2021 | Journal article
Contributors: Murillo, A. M. M.; Tome-Amat, J.; Ramirez, Y.; Garrido-Arandia, M.; Valle, L. G.; Hernandez-Ramirez, G.; Tramarin, L.; Herreros, P.; Santamaria, B.; Diaz-Perales, A. et al.
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Proteomic profile of extracellular vesicles in anaphylaxis and their role in vascular permeability

Allergy
2021 | Journal article
Contributors: Nunez-Borque, Emilio; Fernandez-Bravo, Sergio; Pastor-Vargas, Carlos; Alvarez-Llamas, Gloria; Gutierrez-Blazquez, Maria Dolores; Alwashali, Ebrahim; Laguna, Jose Julio; Dionicio, Javier; Betancor, Diana; Villalobos, Victoria et al.
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Skin damage and pro-inflammatory lipids in anaphylaxis: pru p 3's case

Allergy
2021 | Journal article
Contributors: Pazos-Castro, D.; Gonzalez-Klein, Z.; Hernandez-Ramirez, G.; Romero-Sahagun, A.; Esteban, V; Garrido-Arandia, M.; Diaz-Perales, A.; Tome-Amat, J.
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The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
2021 | Journal article
Contributors: Gonzalez-Klein, Zulema; Cuevas-Zuviria, Bruno; Wangorsch, Andrea; Hernandez-Ramirez, Guadalupe; Pazos-Castro, Diego; Oeo-Santos, Carmen; Romero-Sahagun, Alejandro; Pacios, Luis F.; Tome-Amat, Jaime; Scheurer, Stephan et al.
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Alternaria as an Inducer of Allergic Sensitization

Journal of Fungi
2021-10-07 | Journal article
Contributors: Guadalupe Hernandez-Ramirez; Domingo Barber; Jaime Tome-Amat; Maria Garrido-Arandia; Araceli Diaz-Perales
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Increased miR‐21‐3p and miR‐487b‐3p serum levels during anaphylactic reaction in food allergic children

Pediatric Allergy and Immunology
2021-08 | Journal article
Contributors: Emilio Nuñez‐Borque; Sergio Fernandez‐Bravo; Pablo Rodriguez Del Rio; Ebrahim Mohammed Alwashali; David Lopez‐Dominguez; Maria Dolores Gutierrez‐Blazquez; Jose Julio Laguna; Jaime Tome‐Amat; Julio Gallego‐Delgado; Alicia Gomez‐Lopez et al.
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The Role of Sphingolipids in Allergic Disorders

Frontiers in Allergy
2021-06-14 | Journal article
Part of ISSN: 2673-6101
Source: Self-asserted source
JAIME TOME-AMAT

Group 1 allergens, transported by mold spores, induce asthma exacerbation in a mouse model

Allergy
2020 | Journal article
Contributors: Hernandez-Ramirez, Guadalupe; Pazos-Castro, Diego; Gomez Torrijos, Elisa; Yuste Montalvo, Alma; Romero-Sahagun, Alejandro; Gonzalez-Klein, Zulema; Jimeno-Nogales, Lucia; Escribese, Maria M.; Extremera Ortega, Alba; Nunez-Borque, Emilio et al.
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Phl p 1 homologues from straw might be responsible for allergic phenotypes among pollinic patients in autumn

Allergy
2020 | Journal article
Contributors: Garrido-Arandia, M.; Hernandez-Ramirez, G.; Pazos-Castro, D.; Yuste-Montalvo, A.; Romero-Sahagun, A.; Gonzalez-Klein, Z.; Esteban, V; Tome-Amat, J.; Diaz-Perales, A.
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The skin acts as the preferential sensitizing pathway in an in vivo model of anaphylaxis

Allergy
2020 | Journal article
Contributors: Pazos-Castro, D.; Gonzalez-Klein, Z.; Yuste-Montalvo, A.; Garrido-Arandia, M.; Esteban, V; Diaz-Perales, A.; Tome-Amat, J.
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The TNF-like weak inducer of the apoptosis/fibroblast growth factor-inducible molecule 14 axis mediates histamine and platelet-activating factor-induced subcutaneous vascular leakage and anaphylactic shock

Journal of Allergy and Clinical Immunology
2020 | Journal article
Contributors: Mendez-Barbero, Nerea; Yuste-Montalvo, Alma; Nunez-Borque, Emilio; Jensen, Bettina M.; Gutierrez-Munoz, Carmen; Tome-Amat, Jaime; Garrido-Arandia, Maria; Diaz-Perales, Araceli; Ballesteros-Martinez, Contanza; Julio Laguna, Jose et al.
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Alt a 1 induces immune response in bronchial epithelial cells through SLC22A17

Allergy
2019 | Journal article
Contributors: Garrido-Arandia, M.; Tome-Amat, J.; Hernandez-Ramirez, G.; Romero-Sahagun, A.; Pazos-Castro, D.; Cuevas-Zuviria, B.; Pacios, L. F.; Diaz-Perales, A.
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Association between sensitization to grasses and molds as cause of exacerbation asthma in autumn

Allergy
2019 | Journal article
Contributors: Hernandez-Ramirez, G.; Pazos-Castro, D.; Garrido-Arandia, M.; Tome-Amat, J.; Pazos, L. F.; Diaz-Perales, A.
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Influenza A Virus Utilizes Low-Affinity, High-Avidity Interactions with the Nuclear Import Machinery To Ensure Infection and Immune Evasion

Journal of Virology
2019 | Journal article
Contributors: Tome-Amat, Jaime; Ramos, Irene; Amanor, Ferdinand; Fernandez-Sesma, Ana; Ashour, Joseph
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Interaction of Alt a 1 with SLC22A17 in the airway mucosa

Allergy
2019 | Journal article
Contributors: Garrido-Arandia, Maria; Tome-Amat, Jaime; Pazos-Castro, Diego; Esteban, Vanesa; Escribese, Maria M.; Hernandez-Ramirez, Guadalupe; Yuste-Montalvo, Alma; Barber, Domingo; Pacios, Luis F.; Diaz-Perales, Araceli
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Study of the effects of Pru p 3 sensitization in the MALT

Allergy
2019 | Journal article
Contributors: Tome Amat, J.; Pazos-Castro, D.; Martin-Murillo, A.; Garrido-Arandia, M.; Romero-Sahagun, A.; Cuevas-Zuviria, B.; Pacios, L. F.; Diaz-Perales, A.
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Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Toxins
2019-10-12 | Journal article
Contributors: Javier Ruiz-de-la-Herrán; Jaime Tomé-Amat; Rodrigo Lázaro-Gorines; José Gavilanes; Javier Lacadena
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Allergenicity resulting from functional mimicry of a Lipocalin 2

Allergy
2018 | Journal article
Contributors: Hernandez-Ramirez, G.; Garrido-Arandia, M.; Tome-Amat, J.; Romero-Sahagun, A.; Pacios, F. L.; Diaz-Perales, A.
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Optimization of norovirus virus-like particle production in Pichia pastoris using a real-time near-infrared bioprocess monitor

Biotechnology Progress
2016 | Journal article
Contributors: Parker, Stephanie A.; Maloy, Mitchell H.; Tome-Amat, Jaime; Bardliving, Cameron L.; Batt, Carl A.; Lanz, Kaylee J.; Olesberg, Jonathon T.; Arnold, Mark A.
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alpha-sarcin and RNase T1 based immunoconjugates: the role of intracellular trafficking in cytotoxic efficiency

The FEBS Journal
2015 | Journal article
Contributors: Tome-Amat, Jaime; Ruiz-de-la-Herran, Javier; Martinez-del-Pozo, Alvaro; Gavilanes, Jose G.; Lacadena, Javier
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Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin alpha-sarcin in nude mice bearing human colorectal cancer xenografts

SpringerPlus
2015 | Journal article
Contributors: Tome-Amat, Jaime; Olombrada, Miriam; Ruiz-de-la-Herran, Javier; Perez-Gomez, Eduardo; Andradas, Clara; Sanchez, Cristina; Martinez, Leopoldo; Martinez-del-Pozo, Alvaro; Gavilanes, Jose G.; Lacadena, Javier
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Preparation of an engineered safer immunotoxin against colon carcinoma based on the ribotoxin hirsutellinA

The FEBS Journal
2015 | Journal article
Contributors: Tome-Amat, Jaime; Herrero-Galan, Elias; Onaderra, Mercedes; Martinez-del-Pozo, Alvaro; Gavilanes, Jose G.; Lacadena, Javier
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Secreted production of assembled Norovirus virus-like particles from Pichia pastoris

Microbial Cell Factories
2014 | Journal article
Contributors: Tome-Amat, Jaime; Fleischer, Lauren; Parker, Stephanie A.; Bardliving, Cameron L.; Batt, Carl A.
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Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin -sarcin

Protein Engineering Design and Selection
2012 | Journal article
Contributors: Carreras-Sangra, Nelson; Tome-Amat, Jaime; Garcia-Ortega, Lucia; Batt, Carl A.; Onaderra, Mercedes; Martinez-del-Pozo, Alvaro; Gavilanes, Jose G.; Lacadena, Javier
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Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells

The FEBS Journal
2012 | Journal article
Contributors: Tome-Amat, Jaime; Menendez-Mendez, Aida; Garcia-Ortega, Lucia; Batt, Carl A.; Onaderra, Mercedes; Martinez-del-Pozo, Alvaro; Gavilanes, Jose G.; Lacadena, Javier
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The therapeutic potential of fungal ribotoxins

Current Pharmaceutical Biotechnology
2008 | Journal article
Contributors: Carreras-Sangra, Nelson; Alvarez-Garcia, Elisa; Herrero-Galan, Elias; Tome, Jaime; Lacadena, Javier; Alegre-Cebollada, Jorge; Onaderra, Mercedes; Gavilanes, Jose G.; Martinez-del-Pozo, Alvaro
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Peer review (8 reviews for 4 publications/grants)

Review activity for Cancers. (3)
Review activity for Cell biochemistry and function. (2)
Review activity for International journal of molecular sciences. (2)
Review activity for Pharmaceuticals. (1)