Igor Branchi (0000-0003-4484-3598)

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Biography

My main research interest is in major depression and in the application of an integrative approach, spanning from molecules to the quality of the living environment, in understanding the neural bases of mood disorders and antidepressant efficacy. My current efforts are directed to the investigation of the mechanisms of action of serotoninergic antidepressants in relationship with brain serotonin function, neural plasticity and life quality of the life environment analyzing large clinical dataset through complex data analyses to unravel the complexity of the etiology and treatment of multifactorial disorders

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Istituto Superiore di Sanità: Rome, IT

2021-01-01 to present | Senior Researcher (Center for Behavioral Sciences and Mental Health)

Employment

Igor Branchi

https://orcid.org/0000-0003-4484-3598

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Biography

Activities

Employment (7)

Istituto Superiore di Sanità: Rome, IT

Sapienza University of Rome: Rome, Lazio, IT

Istituto Superiore di Sanità: Rome, IT

Istituto Superiore di Sanità: Roma, Lazio, IT

University of Zurich: Zurich, CH

Conseil National de la Recherche Scientifique: Orléans, FR

Istituto Superiore di Sanità: Roma, Lazio, IT

Education and qualifications (2)

Université d'Orléans: Orleans, FR

Università degli Studi di Roma La Sapienza: Roma, Lazio, IT

Professional activities (17)

European College of Neuropsychopharmacology: Utrecht, NL

European College of Neuropsychopharmacology: Utrecht, NL

European College of Neuropsychopharmacology: Utrecht, NL

European Brain and Behaviour Society: Bordeaux, Aquitaine, FR

European College of Neuropsychopharmacology: Utrecht, NL

Sapienza University of Rome: Rome, IT

Public Library of Science: Cambridge, GB

FENS - Federation of the European Societies of Neuroscience: Bruxelles, BE

European College of Neuropsychopharmacology: Utrecht, NL

European Brain and Behaviour Society: Bordeaux, Aquitaine, FR

Associazione Festival della Scienz: Genoa, IT

European Brain and Behaviour Society: Bordeaux, Aquitaine, FR

European Brain and Behaviour Society: Bordeaux, Aquitaine, FR

European Brain and Behaviour Society: Bordeaux, Aquitaine, FR

International Behavioural and Neural Genetics Society : Bordeaux, FR

International Behavioural and Neural Genetics Society: Bordeaux, FR

International Behavioral Neuroscience Society: San Antonio, Texas, US

Funding (9)

Tuning the immune system activation to enhance neural plasticity: towards an improved treatment strategy for major depressive disorder

Inflammatory control of antidepressant efficacy: a pharmaco-epigenetic approach

Targeting adolescent neurocognitive processes in depression to promote intervention response

Microglial control of synaptic function in stress response and vulnerability to depression

Ricerca Finalizzata - Strategies in potentiating antidepressant efficacy

Innovative approaches to phenotype mood disorders in mouse models - MODELMOOD

Assessment of behavioral and nurobiological alterations in YAC transgenic mice: a mouse model of Down syndrome

Fellowship to work abroad

Fellowship for working abroad

Works (50 of 115)

Integrating plasticity into precision psychiatry

A network-based analysis anticipates time to recovery from major depression revealing a plasticity by context interplay

Breaking free from the inflammatory trap of depression: Regulating the interplay between immune activation and plasticity to foster mental health

Uncovering the determinants of brain functioning, behavior and their interplay in the light of context

Psychometric network inference: A comparative analysis

Adolescent social isolation induces sex-specific behavioral and neural alterations

Taming Complexity from the Interface: Simplifying Neuroscience

Towards a network-based operationalization of plasticity for predicting the transition from depression to mental health

A mathematical formula of plasticity: Measuring susceptibility to change in mental health and data science

Uncovering the determinants of brain functioning, behavior and their interplay in the light of context

Transition From Depression to Mental Health: Toward an Operationalization of Plasticity

Recentering neuroscience on behavior: The interface between brain and environment is a privileged level of control of neural activity

Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process

The challenge of complexity in the Big Data era: how to ride the wave of high-dimensional data revolution. Editorial.

PLASTICITY IN MENTAL HEALTH: A NETWORK THEORY

The impact of the prolonged COVID-19 pandemic on stress resilience and mental health: A critical review across waves.

Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice.

Selecting antidepressants according to a drug-by-environment interaction: A comparison of fluoxetine and minocycline effects in mice living either in enriched or stressful conditions

Adiponectin predicts poor response to antidepressant drugs in major depressive disorder.

The Intellicage system provides a reproducible and standardized method to assess behavioral changes in cuprizone-induced demyelination mouse model

Severe mental illness and European COVID-19 vaccination strategies.

Viewpoint | European COVID-19 exit strategy for people with severe mental disorders: Too little, but not yet too late.

Brain-immune crosstalk in the treatment of major depressive disorder.

Shaping therapeutic trajectories in mental health: Instructive vs. permissive causality.

Higher baseline interleukin-1β and TNF-α hamper antidepressant response in major depressive disorder.

A peripheral inflammatory signature discriminates bipolar from unipolar depression: A machine learning approach.

Stress resilience during the coronavirus pandemic.

Predicting antidepressant treatment outcome based on socioeconomic status and citalopram dose

Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression.

Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus.

Psychedelics and the essential importance of context.

Citalopram amplifies the influence of living conditions on mood in depressed patients enrolled in the STAR*D study