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synaptic plasticity, learning and memory, cognitive disorders, psychiatric disorders
Canada

Activities

Employment (1)

Lunenfeld-Tanenbaum Research Institute: Toronto, ON, CA

Staff Scientist (Neurobiology)
Employment
Source: Self-asserted source
John Georgiou

Education and qualifications (1)

University of Toronto: Toronto, ON, CA

1999 | Ph.D. (Department of Physiology)
Education
Source: Self-asserted source
John Georgiou

Professional activities (2)

Canadian Association for Neuroscience: Victoria, British Columbia, CA

1994-03-15 to present | Regular
Membership
Source: Self-asserted source
John Georgiou

Society for Neuroscience: Washington, DC, US

1991 to present | Regular
Membership
Source: Self-asserted source
John Georgiou

Works (50 of 64)

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Page 1 of 2

Brain Microenvironment-Remodeling Nanomedicine Improves Cerebral Glucose Metabolism, Mitochondrial Activity and Synaptic Function in a Mouse Model of Alzheimer's Disease

SSRN
2024 | Other
EID:

2-s2.0-85204883404

Part of ISSN: 15565068
Contributors: Park, E.; He, C.; Abbasi, A.Z.; Tian, M.; Huang, S.; Wang, L.; Georgiou, J.; Collingridge, G.L.; Fraser, P.E.; Henderson, J.T. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier

Cage effects on synaptic plasticity and its modulation in a mouse model of fragile X syndrome

Philosophical Transactions of the Royal Society B: Biological Sciences
2024 | Journal article
EID:

2-s2.0-85195626017

Part of ISSN: 14712970 09628436
Contributors: Volianskis, R.; Lundbye, C.J.; Petroff, G.N.; Jane, D.E.; Georgiou, J.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Incremental induction of NMDAR-STP and NMDAR-LTP in the CA1 area of ventral hippocampal slices relies on graded activation of discrete NMDA receptors

Philosophical Transactions of the Royal Society B: Biological Sciences
2024 | Journal article
EID:

2-s2.0-85195624375

Part of ISSN: 14712970 09628436
Contributors: Ingram, R.; Volianskis, R.; Georgiou, J.; Jane, D.E.; Michael-Titus, A.T.; Collingridge, G.L.; Volianskis, A.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Optogenetic elevation of postsynaptic cGMP in the hippocampal dentate gyrus enhances LTP and modifies mouse behaviors

Frontiers in Molecular Neuroscience
2024 | Journal article
EID:

2-s2.0-85211326058

Part of ISSN: 16625099
Contributors: Borovac, J.; Rai, J.; Valencia, M.; Li, H.; Georgiou, J.; Collingridge, G.L.; Takao, K.; Okamoto, K.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier

Role of calcium-permeable AMPARs in synaptic tagging and capture in the rodent hippocampus

Synaptic Tagging and Capture: From Synapses to Behavior: Second Edition
2024 | Book chapter
EID:

2-s2.0-85204671979

Contributors: Koek, L.A.; Park, P.; Sanderson, T.M.; Georgiou, J.; Zhuo, M.; Kaang, B.-K.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Role of Calcium-Permeable AMPARs in Synaptic Tagging and Capture in the Rodent Hippocampus

Synaptic Tagging and Capture
2024 | Book chapter
Part of ISBN: 9783031548642
Contributors: Laura A. Koek; Pojeong Park; Thomas M. Sanderson; John Georgiou; Min Zhuo; Bong-Kiun Kaang; Graham L. Collingridge
Source: Self-asserted source
John Georgiou via Crossref Metadata Search

The role of calcium stores in long-term potentiation and synaptic tagging and capture in mouse hippocampus

Philosophical Transactions of the Royal Society B: Biological Sciences
2024 | Journal article
EID:

2-s2.0-85195622279

Part of ISSN: 14712970 09628436
Contributors: Koek, L.A.; Sanderson, T.M.; Georgiou, J.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Activation of group I mGluRs is required for heterosynaptic priming of long-term potentiation in mouse hippocampus

2024-09-27 | Preprint
Contributors: Laura A. Koek; Thomas M. Sanderson; John Georgiou; Graham L. Collingridge
Source: check_circle
Crossref
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Grin1Y647S/+Mice: A Preclinical Model ofGRIN1-Related Neurodevelopmental Disorder

2024-08-21 | Preprint
Contributors: Megan T. Sullivan; Patrick Tidball; Yuanye Yan; Katheron Intson; Wenjuan Chen; Yuchen Xu; Sridevi Venkatesan; Wendy Horsfall; John Georgiou; Peter S.B. Finnie et al.
Source: check_circle
Crossref
grade
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Sex-dependence of synaptic depression induced by activation of metabotropic glutamate receptors in rat hippocampus

Brain and Neuroscience Advances
2024-01 | Journal article
Contributors: Liam T. Ralph; John Georgiou; Graham L. Collingridge; Patrick Tidball
Source: check_circle
Crossref

Amyloid-β<sub>1-42</sub> oligomers enhance mGlu<sub>5</sub>R-dependent synaptic weakening via NMDAR activation and complement C5aR1 signaling

iScience
2023 | Journal article
EID:

2-s2.0-85177035648

Part of ISSN: 25890042
Contributors: Ng, A.N.; Salter, E.W.; Georgiou, J.; Bortolotto, Z.A.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier

Amyloid-β<sub>1-42</sub> oligomers enhance mGlu<sub>5</sub>R-dependent synaptic weakening via NMDAR activation and complement C3aR/C5aR signaling

bioRxiv
2022 | Other
EID:

2-s2.0-85143722840

Part of ISSN: 26928205
Contributors: Ng, A.N.; Salter, E.W.; Georgiou, J.; Bortolotto, Z.A.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Specific Role for GSK3α in Limiting Long-Term Potentiation in CA1 Pyramidal Neurons of Adult Mouse Hippocampus.

Frontiers in molecular neuroscience
2022-06-17 | Journal article
Contributors: Ebrahim Amini A; Miyata T; Lei G; Jin F; Rubie E; Bradley CA; Woodgett JR; Collingridge GL; Georgiou J
Source: Self-asserted source
John Georgiou
grade
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Selective Recruitment of Presynaptic and Postsynaptic Forms of mGluR-LTD.

Frontiers in synaptic neuroscience
2022-05-09 | Journal article
Contributors: Thomas Sanderson; Ralph LT; Amici M; Ng AN; Kaang BK; Zhuo M; Kim SJ; Georgiou J; Collingridge GL
Source: Self-asserted source
John Georgiou
grade
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Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices

Neuropharmacology
2021 | Journal article
EID:

2-s2.0-85117106841

Part of ISSN: 18737064 00283908
Contributors: Eapen, A.V.; Fernández-Fernández, D.; Georgiou, J.; Bortolotto, Z.A.; Lightman, S.; Jane, D.E.; Volianskis, A.; Collingridge, G.L.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications
2021 | Journal article
EID:

2-s2.0-85099438061

Part of ISSN: 20411723
Contributors: Park, P.; Georgiou, J.; Sanderson, T.M.; Ko, K.-H.; Kang, H.; Kim, J.-I.; Bradley, C.A.; Bortolotto, Z.A.; Zhuo, M.; Kaang, B.-K. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators.

Neuropharmacology
2021-10-20 | Journal article
Contributors: France G; Volianskis R; Ingram R; Bannister N; Rothärmel R; Irvine MW; Fang G; Burnell ES; Sapkota K; BLAISE M COSTA et al.
Source: Self-asserted source
John Georgiou
grade
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Further evidence that CP-AMPARs are critically involved in synaptic tag and capture at hippocampal CA1 synapses.

Molecular brain
2021-02-01 | Journal article
EID:

2-s2.0-85100077068

Part of ISSN: 17566606
EID:

2-s2.0-85098811412

Part of ISSN: 26928205
Source: Self-asserted source
John Georgiou
grade
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Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus.

Frontiers in neural circuits
2020-06-03 | Journal article
Source: Self-asserted source
John Georgiou
grade
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Complement C3-dependent glutamatergic synapse elimination in the developing hippocampus is region- and synapse-specific

[]
2020-05-22 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 3)‎

Illuminating Relationships Between the Pre- and Post-synapse.

Frontiers in neural circuits
2020-04-02 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 2)‎

(2S,6S)- and (2R,6R)-hydroxynorketamine inhibit the induction of NMDA receptor-dependent LTP at hippocampal CA1 synapses in mice

Brain and Neuroscience Advances
2020-01 | Journal article
Contributors: Heather Kang; Pojeong Park; Muchun Han; Patrick Tidball; John Georgiou; Zuner A. Bortolotto; David Lodge; Bong-Kiun Kaang; Graham L. Collingridge
Source: check_circle
Crossref

Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.

Molecular cell
2020-01-29 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 2)‎

Mice lacking neuronal calcium sensor-1 show social and cognitive deficits.

Behavioural brain research
2019-12-09 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 2)‎

The Hippocampus Is the Place to Be: Opioid Receptors and LTP.

Cell reports
2019-07-01 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 2)‎

Differential sensitivity of three forms of hippocampal synaptic potentiation to depotentiation.

Molecular brain
2019-04-03 | Journal article
Source: Self-asserted source
John Georgiou
grade
Preferred source (of 2)‎

On the Role of Calcium-Permeable AMPARs in Long-Term Potentiation and Synaptic Tagging in the Rodent Hippocampus.

Frontiers in synaptic neuroscience
2019-03-14 | Journal article
Source: Self-asserted source
John Georgiou
grade
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The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

Cell reports
2018-12-01 | Journal article
Source: Self-asserted source
John Georgiou
grade
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The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus.

Frontiers in synaptic neuroscience
2018-11-22 | Journal article
Source: Self-asserted source
John Georgiou
grade
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Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
2017-04 | Journal article
Contributors: McGirr A; Lipina TV; Mun HS; Georgiou J; Al-Amri AH; Ng E; Zhai D; Elliott C; Cameron RT; Mullins JG et al.
Source: Self-asserted source
John Georgiou via Europe PubMed Central

A cautionary (spectral) tail: Red-shifted fluorescence by DAPI-DAPI interactions

Biochemical Society Transactions
2016 | Journal article
EID:

2-s2.0-84957921483

Part of ISSN: 14708752 03005127
Contributors: Omelon, S.; Georgiou, J.; Habraken, W.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition

Neuropsychopharmacology
2016 | Journal article
EID:

2-s2.0-84957442782

Part of ISSN: 1740634X 0893133X
Contributors: Mcgirr, A.; Lipina, T.V.; Mun, H.-S.; Georgiou, J.; Al-Amri, A.H.; Ng, E.; Zhai, D.; Elliott, C.; Cameron, R.T.; Mullins, J.G. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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A far-red emitting probe for unambiguous detection of mobile zinc in acidic vesicles and deep tissue

Chemical Science
2015 | Journal article
EID:

2-s2.0-84923170112

Part of ISSN: 20416539 20416520
Contributors: Rivera-Fuentes, P.; Wrobel, A.T.; Zastrow, M.L.; Khan, M.; Georgiou, J.; Luyben, T.T.; Roder, J.C.; Okamoto, K.; Lippard, S.J.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Hippocampal place cell and inhibitory neuron activity in disrupted-in-schizophrenia-1 mutant mice: implications for working memory deficits

npj Schizophrenia
2015 | Journal article
EID:

2-s2.0-85052711315

Part of ISSN: 2334265X
Contributors: Mesbah-Oskui, L.; Georgiou, J.; Roder, J.C.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Novel EP4 receptor agonist-bisphosphonate conjugate drug (C1) promotes bone formation and improves vertebral mechanical properties in the ovariectomized rat model of postmenopausal bone loss

Journal of Bone and Mineral Research
2015 | Journal article
EID:

2-s2.0-84925448662

Part of ISSN: 15234681 08840431
Contributors: Liu, C.C.; Hu, S.; Chen, G.; Georgiou, J.; Arns, S.; Kumar, N.S.; Young, R.N.; Grynpas, M.D.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Self-directed exploration provides a Ncs1-dependent learning bonus

Scientific Reports
2015 | Journal article
EID:

2-s2.0-84949525703

Part of ISSN: 20452322
Contributors: Mun, H.-S.; Saab, B.J.; Ng, E.; Mcgirr, A.; Lipina, T.V.; Gondo, Y.; Georgiou, J.; Roder, J.C.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Colocation and role of polyphosphates and alkaline phosphatase in apatite biomineralization of elasmobranch tesserae

Acta Biomaterialia
2014 | Conference paper
EID:

2-s2.0-84905580426

Part of ISSN: 18787568 17427061
Contributors: Omelon, S.; Georgiou, J.; Variola, F.; Dean, M.N.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Two-photon imaging of Zn<sup>2+</sup> dynamics in mossy fiber boutons of adult hippocampal slices

Proceedings of the National Academy of Sciences of the United States of America
2014 | Journal article
EID:

2-s2.0-84899830883

Part of ISSN: 10916490 00278424
Contributors: Khan, M.; Goldsmith, C.R.; Huang, Z.; Georgiou, J.; Luyben, T.T.; Roder, J.C.; Lippard, S.J.; Okamoto, K.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Neurons Refine the Caenorhabditis elegans Body Plan by Directing Axial Patterning by Wnts

PLoS Biology
2013 | Journal article
EID:

2-s2.0-84873832597

Part of ISSN: 15449173 15457885
Contributors: Modzelewska, K.; Lauritzen, A.; Hasenoeder, S.; Brown, L.; Georgiou, J.; Moghal, N.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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A 3D scanning confocal imaging method measures pit volume and captures the role of Rac in osteoclast function

Bone
2012 | Journal article
EID:

2-s2.0-84861209373

Part of ISSN: 87563282
Contributors: Goldberg, S.R.; Georgiou, J.; Glogauer, M.; Grynpas, M.D.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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A Co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel

Molecular Brain
2011 | Journal article
EID:

2-s2.0-79953851820

Part of ISSN: 17566606
Contributors: Bouhours, M.; Po, M.D.; Gao, S.; Hung, W.; Li, H.; Georgiou, J.; Roder, J.C.; Zhen, M.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination

Development
2011 | Journal article
EID:

2-s2.0-79955159546

Part of ISSN: 09501991 14779129
Contributors: Jin, F.; Dong, B.; Georgiou, J.; Jiang, Q.; Zhang, J.; Bharioke, A.; Qiu, F.; Lommel, S.; Laura Feltri, M.; Wrabetz, L. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions

Journal of Neuroscience
2011 | Journal article
EID:

2-s2.0-80051572159

Part of ISSN: 02706474 15292401
Contributors: Mohseni, P.; Sung, H.-K.; Murphy, A.J.; Laliberte, C.L.; Pallari, H.-M.; Henkelman, M.; Georgiou, J.; Xie, G.; Quaggin, S.E.; Thorner, P.S. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Oligomeric size of the M<sub>2</sub> muscarinic receptor in live cells as determined by quantitative fluorescence resonance energy transfer

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77952757509

Part of ISSN: 00219258 1083351X
Contributors: Pisterzi, L.F.; Jansma, D.B.; Georgiou, J.; Woodside, M.J.; Tai-Chieh Chou, J.; Angers, S.; Raicu, V.; Wells, J.W.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Control of vertebrate skeletal mineralization by polyphosphates

PLoS ONE
2009 | Journal article
EID:

2-s2.0-66249091999

Part of ISSN: 19326203
Contributors: Omelon, S.; Georgiou, J.; Henneman, Z.J.; Wise, L.M.; Sukhu, B.; Hunt, T.; Wynnyckyj, C.; Holmyard, D.; Bielecki, R.; Grynpas, M.D.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Corrigendum to "[P1.41] A critical role for N-WASp in cell migration during central nervous system development" [International Journal of Developmental Neuroscience 26(8) p. 855 (2008)] (DOI:10.1016/j.ijdevneu.2008.09.091)

International Journal of Developmental Neuroscience
2009 | Journal article
EID:

2-s2.0-65549152127

Part of ISSN: 07365748
Contributors: Jin, F.J.; Bharioke, A.; Zhang, J.Y.; Kuhlmann, T.K.; Georgiou, J.G.; Lommel, S.L.; Siminovitch, K.S.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier

NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory

Neuron
2009 | Journal article
EID:

2-s2.0-69949092092

Part of ISSN: 08966273
Contributors: Saab, B.J.; Georgiou, J.; Nath, A.; Lee, F.J.S.; Wang, M.; Michalon, A.; Liu, F.; Mansuy, I.M.; Roder, J.C.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Huntingtin-interacting protein 1 influences worm and mouse presynaptic function and protects Caenorhabditis elegans neurons against mutant polyglutamine toxicity

Journal of Neuroscience
2007 | Journal article
EID:

2-s2.0-35348913211

Part of ISSN: 02706474 02706474
Contributors: Parker, J.A.; Metzler, M.; Georgiou, J.; Mage, M.; Roder, J.C.; Rose, A.M.; Hayden, M.R.; Néri, C.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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Nck adaptor proteins control the organization of neuronal circuits important for walking

Proceedings of the National Academy of Sciences of the United States of America
2007 | Journal article
EID:

2-s2.0-38049173095

Part of ISSN: 00278424 10916490
Contributors: Fawcett, J.P.; Georgiou, J.; Ruston, J.; Bladt, F.; Sherman, A.; Warner, N.; Saab, B.J.; Scott, R.; Roder, J.C.; Pawson, T.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
grade
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NMDA receptor function and NMDA receptor-dependent phosphorylation of huntingtin is altered by the endocytic protein HIP1

Journal of Neuroscience
2007 | Journal article
EID:

2-s2.0-33847359131

Part of ISSN: 02706474 02706474
Contributors: Metzler, M.; Gan, L.; Tak, P.W.; Liu, L.; Helm, J.; Liu, L.; Georgiou, J.; Wang, Y.; Bissada, N.; Cheng, K. et al.
Source: Self-asserted source
John Georgiou via Scopus - Elsevier
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Peer review (2 reviews for 1 publication/grant)

Review activity for Molecular brain (2)