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Scopus Author ID: 53264361300

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Employment (1)

Michigan State University: East Lansing, MI, US

2015-08-16 to present | Associate Professor (Biochemistry and Molecular Biology)
Employment
Source: Self-asserted source
Sophia Lunt

Education and qualifications (2)

Massachusetts Institute of Technology: Cambridge, MA, US

2010-09-02 to 2015-08-15 | Postdoctoral (Biology)
Education
Source: Self-asserted source
Sophia Lunt

Princeton University: Princeton, NJ, US

2005-07-01 to 2010-09-01 | Ph.D. (Chemistry)
Education
Source: Self-asserted source
Sophia Lunt

Professional activities (4)

Metabolomics Society: Boston, US

Membership
Source: Self-asserted source
Sophia Lunt

Metabolomics Association of North America: Atlanta, US

Membership
Source: Self-asserted source
Sophia Lunt

Cancer Epigenetics Society: Vienna, AT

Membership
Source: Self-asserted source
Sophia Lunt

American Association for Cancer Research: Philadelphia, PA, US

Membership
Source: Self-asserted source
Sophia Lunt

Funding (5)

CAREER: Engineering Tunable Fluorescent Organic Salts for Next Generation Imaging and Photodynamic Therapy

2019-03-01 to 2024-02-29 | Grant
Directorate for Engineering (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.7912672
GRANT_NUMBER: 1845006
Source: Self-asserted source
Sophia Lunt via DimensionsWizard

Deciphering Metabolic Rewiring in Cancer

2016-07-01 to 2020-06-30 | Grant
American Association For Cancer Research (Philadelphia, US)
URL: https://app.dimensions.ai/details/grant/grant.6616065
GRANT_NUMBER:

16-20-46-LUNT
Source: Self-asserted source
Sophia Lunt via DimensionsWizard

Metabolomic Targeting of Heterogeneous Breast Cancer for Personalized Therapy Development

2013-10-01 to 2014-09-01 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
URL: https://app.dimensions.ai/details/grant/grant.7137206
GRANT_NUMBER:

W81XWH-15-1-0453
Source: Self-asserted source
Sophia Lunt via DimensionsWizard

Understanding the Warburg Effect and the Metabolic Requirements of Cancer Cells

2012-09-15 to 2015-09-14 | Grant
Congressionally Directed Medical Research Programs (Fort Detrick, US)
GRANT_NUMBER:

W81XWH1210466

GRANT_NUMBER: W81XWH1210466
Source: Self-asserted source
Sophia Lunt via DimensionsWizard

Understanding the Warburg Effect and the Metabolic Requirements of Cancer Cells

2010-10-01 to 2011-09-01 | Grant
Congressionally Directed Medical Research Programs (Frederick, US)
URL: https://app.dimensions.ai/details/grant/grant.7140120
GRANT_NUMBER:

W81XWH-12-1-0466
Source: Self-asserted source
Sophia Lunt via DimensionsWizard

Works (50 of 56)

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Page 1 of 2

Next‐Generation Photosensitizers: Cyanine‐Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer

Angewandte Chemie
2025-02-24 | Journal article
DOI: 10.1002/ange.202419759
Contributors: Amir Roshanzadeh; Hyllana C. D. Medeiros; Christopher K. Herrera; Carson Malhado; Anton W. Tomich; Steven P. Fisher; Sergio O. Lovera; Matthew Bates; Vincent Lavallo; Richard R. Lunt et al.
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Crossref

Next‐Generation Photosensitizers: Cyanine‐Carborane Salts for Superior Photodynamic Therapy of Metastatic Cancer

Angewandte Chemie International Edition
2025-02-24 | Journal article
DOI: 10.1002/anie.202419759
Contributors: Amir Roshanzadeh; Hyllana C. D. Medeiros; Christopher K. Herrera; Carson Malhado; Anton W. Tomich; Steven P. Fisher; Sergio O. Lovera; Matthew Bates; Vincent Lavallo; Richard R. Lunt et al.
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Crossref

The liver converts fructose into lipids to fuel tumours

Nature
2024-12-19 | Journal article
DOI: 10.1038/d41586-024-03653-2
Contributors: Hyllana C. D. Medeiros; Sophia Y. Lunt
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Crossref

Enhanced Lifetime of Cyanine Salts in Dilute Matrix Luminescent Solar Concentrators via Counterion Tuning

ACS Photonics
2023-09-20 | Journal article
DOI: 10.1021/acsphotonics.3c00602
Contributors: Christopher K. Herrera; Aria Vahdani; Chenchen Yang; Matthew Bates; Sophia Y. Lunt; Babak Borhan; Richard R. Lunt
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Crossref

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

2023-09-17 | Preprint
DOI: 10.1101/2023.09.15.557984
Contributors: Elliot Ensink; Tessa Jordan; Hyllana C D Medeiros; Galloway Thurston; Anmol Pardal; Lei Yu; Sophia Y. Lunt
Source: check_circle
Crossref

Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6511936
Contributors: Amanda E. Brinker; Carolyn J. Vivian; Thomas C. Beadnell; Devin C. Koestler; Shao Thing Teoh; Sophia Y. Lunt; Danny R. Welch
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Crossref

Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6511936.v1
Contributors: Amanda E. Brinker; Carolyn J. Vivian; Thomas C. Beadnell; Devin C. Koestler; Shao Thing Teoh; Sophia Y. Lunt; Danny R. Welch
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Crossref

Data from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6512697
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
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Crossref

Data from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.c.6512697.v1
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22425064.v1
Contributors: Amanda E. Brinker; Carolyn J. Vivian; Thomas C. Beadnell; Devin C. Koestler; Shao Thing Teoh; Sophia Y. Lunt; Danny R. Welch
Source: check_circle
Crossref

Supplementary Data from Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22425064
Contributors: Amanda E. Brinker; Carolyn J. Vivian; Thomas C. Beadnell; Devin C. Koestler; Shao Thing Teoh; Sophia Y. Lunt; Danny R. Welch
Source: check_circle
Crossref

Supplementary Material from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22427493
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Supplementary Material from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22427493.v1
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Supplementary Tables from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22427487
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Supplementary Tables from Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

2023-03-31 | Preprint
DOI: 10.1158/0008-5472.22427487.v1
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy

Chemistry – A European Journal
2023-02 | Journal article
DOI: 10.1002/chem.202202881
Contributors: Hyllana C. D. Medeiros; Chenchen Yang; Christopher K. Herrera; Deanna Broadwater; Elliot Ensink; Matthew Bates; Richard R. Lunt; Sophia Y. Lunt
Source: check_circle
Crossref

Counterion Tuning of Near-Infrared Organic Salts Dictates Phototoxicity to Inhibit Tumor Growth

ACS Applied Materials & Interfaces
2022-12-07 | Journal article
DOI: 10.1021/acsami.2c16252
Contributors: Deanna Broadwater; Hyllana C. D. Medeiros; Matthew Bates; Amir Roshanzadeh; Shao Thing Teoh; Martin P. Ogrodzinski; Babak Borhan; Richard R. Lunt; Sophia Y. Lunt
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Crossref

Impact of charge character on anionic cyanine-based organic salt photovoltaics

Journal of Applied Physics
2022-08-28 | Journal article
DOI: 10.1063/5.0104901
Contributors: Matthew Bates; Sophia Y. Lunt; Richard R. Lunt
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Crossref

Combined Plasma and Urinary Metabolomics Uncover Metabolic Perturbations Associated with Severe Respiratory Syncytial Viral Infection and Future Development of Asthma in Infant Patients

Metabolites
2022-02-14 | Journal article
DOI: 10.3390/metabo12020178
Contributors: Shao Thing Teoh; Mara L. Leimanis-Laurens; Sarah S. Comstock; John W. Winters; Nikita L. Vandenbosch; Jeremy W. Prokop; André S. Bachmann; Sophia Y. Lunt; Surender Rajasekaran
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Loss of Health Promoting Bacteria in the Gastrointestinal Microbiome of PICU Infants with Bronchiolitis: A Single-Center Feasibility Study

Children
2022-01-17 | Journal article
DOI: 10.3390/children9010114
Contributors: Madeleine M. Russell; Mara L. Leimanis-Laurens; Sihan Bu; Gigi A. Kinney; Shao Thing Teoh; Ruth-Anne L. McKee; Karen Ferguson; John W. Winters; Sophia Y. Lunt; Jeremy W. Prokop et al.
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Crossref
grade
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Targeting Subtype-Specific Metabolic Preferences in Nucleotide Biosynthesis Inhibits Tumor Growth in a Breast Cancer Model

Cancer Research
2021-01-15 | Journal article
DOI: 10.1158/0008-5472.CAN-20-1666
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Genomic and metabolomic analysis of step-wise malignant transformation in human skin fibroblasts

Carcinogenesis
2020-07-10 | Journal article
DOI: 10.1093/carcin/bgz126
Contributors: Anastasia Kariagina; Sophia Y Lunt; J Justin McCormick
Source: check_circle
Crossref

UDP-Glucose 6-Dehydrogenase Knockout Impairs Migration and Decreasesin vivoMetastatic Ability of Breast Cancer Cells

2020-05-31 | Preprint
DOI: 10.1101/2020.05.30.125419
Contributors: Shao Thing Teoh; Martin P. Ogrodzinski; Sophia Y. Lunt
Source: check_circle
Crossref

Targeting subtype-specific metabolic preferences in nucleotide biosynthesis inhibits tumor growth in a breast cancer model

2020-04-20 | Preprint
DOI: 10.1101/2020.04.19.049577
Contributors: Martin P. Ogrodzinski; Shao Thing Teoh; Sophia Y. Lunt
Source: check_circle
Crossref

Mitochondrial Haplotype of the Host Stromal Microenvironment Alters Metastasis in a Non-cell Autonomous Manner

Cancer Research
2020-03-01 | Journal article
DOI: 10.1158/0008-5472.CAN-19-2481
Contributors: Amanda E. Brinker; Carolyn J. Vivian; Thomas C. Beadnell; Devin C. Koestler; Shao Thing Teoh; Sophia Y. Lunt; Danny R. Welch
Source: check_circle
Crossref

Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells

Cancer & Metabolism
2019-12 | Journal article
DOI: 10.1186/s40170-019-0205-z
Contributors: Lei Yu; Shao Thing Teoh; Elliot Ensink; Martin P. Ogrodzinski; Che Yang; Ana I. Vazquez; Sophia Y. Lunt
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Crossref

Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes

2019-10-07 | Other
DOI: 10.1101/796573
Contributors: Martin P. Ogrodzinski; Sophia Y. Lunt
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Crossref

Integrated analyses of murine breast cancer models reveal critical parallels with human disease.

Nature communications
2019-07-22 | Journal article
DOI: 10.1038/s41467-019-11236-3
PMID: 31332182
PMC: PMC6646342
Source: Self-asserted source
Sophia Lunt

Measuring the Nutrient Metabolism of Adherent Cells in Culture.

Methods in molecular biology (Clifton, N.J.)
2019-01-01 | Journal article
DOI: 10.1007/978-1-4939-8769-6_3
PMID: 30315458
Source: Self-asserted source
Sophia Lunt

Enhanced Electroluminescence Efficiency in Metal Halide Nanocluster Based Light Emitting Diodes through Apical Halide Exchange

ACS Applied Energy Materials
2018-08-27 | Journal article
DOI: 10.1021/acsaem.8b00837
Part of ISSN: 2574-0962
Part of ISSN: 2574-0962
Source: Self-asserted source
Sophia Lunt

Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics.

Frontiers in Oncology
2018-05-28 | Journal article
DOI: 10.3389/fonc.2018.00174
PMID: 29892572
PMC: PMC5985449
Source: Self-asserted source
Sophia Lunt

Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

Current Opinion in Systems Biology
2018-04 | Journal article
DOI: 10.1016/j.coisb.2017.12.006
Part of ISSN: 2452-3100
Source: Self-asserted source
Sophia Lunt

Impact of Ultrathin C60 on Perovskite Photovoltaic Devices.

ACS nano
2018-01-05 | Journal article
DOI: 10.1021/acsnano.7b08561
PMID: 29286630
Source: Self-asserted source
Sophia Lunt

Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells.

Oncotarget
2017-12-23 | Journal article
DOI: 10.18632/oncotarget.23661
PMID: 29423103
PMC: PMC5790520
Source: Self-asserted source
Sophia Lunt

Deciphering metabolic rewiring in breast cancer subtypes

Translational Research
2017-11 | Journal article
DOI: 10.1016/j.trsl.2017.07.004
Contributors: Martin P. Ogrodzinski; Jamie J. Bernard; Sophia Y. Lunt
Source: check_circle
Crossref

Anions for Near-Infrared Selective Organic Salt Photovoltaics

Scientific Reports
2017-11-27 | Journal article
DOI: 10.1038/s41598-017-16539-3
Contributors: Christopher J. Traverse; Margaret Young; John Suddard-Bangsund; Tyler Patrick; Matthew Bates; Pei Chen; Brian Wingate; Sophia Y. Lunt; Annick Anctil; Richard R. Lunt
Source: check_circle
Crossref

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond.

Wiley interdisciplinary reviews. Systems biology and medicine
2017-10-09 | Journal article
DOI: 10.1002/wsbm.1406
PMID: 28990735
Source: Self-asserted source
Sophia Lunt

Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer.

Oncogene
2017-08-07 | Journal article
DOI: 10.1038/onc.2017.278
PMID: 28783178
PMC: PMC5709202
Source: Self-asserted source
Sophia Lunt

Prediction of years of life after diagnosis of breast cancer using omics and omic-by-treatment interactions.

European journal of human genetics : EJHG
2017-03-08 | Journal article
DOI: 10.1038/ejhg.2017.12
PMID: 28272536
PMC: PMC5437894
Source: Self-asserted source
Sophia Lunt

Dose-Dependent Metabolic Reprogramming and Differential Gene Expression in TCDD-Elicited Hepatic Fibrosis.

Toxicological sciences : an official journal of the Society of Toxicology
2016-08-25 | Journal article
DOI: 10.1093/toxsci/kfw163
PMID: 27562557
PMC: PMC5139066
Source: Self-asserted source
Sophia Lunt

Organic Heptamethine Salts for Photovoltaics and Detectors with Near-Infrared Photoresponse up to 1600 nm

Advanced Optical Materials
2016-07 | Journal article
DOI: 10.1002/adom.201600102
Part of ISSN: 2195-1071
Source: Self-asserted source
Sophia Lunt

A roadmap for interpreting 13C metabolite labeling patterns from cells

Current Opinion in Biotechnology
2015 | Journal article
DOI: 10.1016/j.copbio.2015.02.003
EID:

2-s2.0-84923596826
Contributors: Buescher, J.M.; Antoniewicz, M.R.; Boros, L.G.; Burgess, S.C.; Brunengraber, H.; Clish, C.B.; DeBerardinis, R.J.; Feron, O.; Frezza, C.; Ghesquiere, B. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier

Erratum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells (Nature (2015) 520 (192-197) DOI:10.1038/nature14362)

Nature
2015 | Journal article
DOI: 10.1038/nature14624
EID:

2-s2.0-84943140705
Contributors: Schoors, S.; Bruning, U.; Missiaen, R.; Queiroz, K.C.S.; Borgers, G.; Elia, I.; Zecchin, A.; Cantelmo, A.R.; Christen, S.; Goveia, J. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

Nature
2015 | Journal article
DOI: 10.1038/nature14362
EID:

2-s2.0-84927563455
Contributors: Schoors, S.; Bruning, U.; Missiaen, R.; Queiroz, K.C.S.; Borgers, G.; Elia, I.; Zecchin, A.; Cantelmo, A.R.; Christen, S.; Goveia, J. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier

Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation

Molecular Cell
2015 | Journal article
DOI: 10.1016/j.molcel.2014.10.027
EID:

2-s2.0-84920447418
Contributors: Lunt, S.Y.; Muralidhar, V.; Hosios, A.M.; Israelsen, W.J.; Gui, D.Y.; Newhouse, L.; Ogrodzinski, M.; Hecht, V.; Xu, K.; Acevedo, P.N.M. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier

Pyruvate Kinase Isoform Switching and Hepatic Metabolic Reprogramming by the Environmental Contaminant 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Toxicological sciences : an official journal of the Society of Toxicology
2015-11-17 | Journal article
DOI: 10.1093/toxsci/kfv245
PMID: 26582802
PMC: PMC4900217
Source: Self-asserted source
Sophia Lunt

Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism.

Cancer & metabolism
2014-12-15 | Journal article
DOI: 10.1186/2049-3002-2-21
PMID: 25671108
PMC: PMC4322794
Source: Self-asserted source
Sophia Lunt

Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.

Clinical cancer research : an official journal of the American Association for Cancer Research
2013-02-12 | Journal article
DOI: 10.1158/1078-0432.CCR-12-2307
PMID: 23403635
PMC: PMC3951107
Source: Self-asserted source
Sophia Lunt
grade
Preferred source (of 2)‎

Erratum: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (Nature Chemical Biology (2012) 8 (839-847))

Nature Chemical Biology
2012 | Journal article
DOI: 10.1038/nchembio1212-1008b
EID:

2-s2.0-84870307209
Contributors: Anastasiou, D.; Yu, Y.; Israelsen, W.J.; Jiang, J.-K.; Boxer, M.B.; Hong, B.S.; Tempel, W.; Dimov, S.; Shen, M.; Jha, A. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

Nature Chemical Biology
2012 | Journal article
DOI: 10.1038/nchembio.1060
EID:

2-s2.0-84866842363
Contributors: Anastasiou, D.; Yu, Y.; Israelsen, W.J.; Jiang, J.-K.; Boxer, M.B.; Hong, B.S.; Tempel, W.; Dimov, S.; Shen, M.; Jha, A. et al.
Source: Self-asserted source
Sophia Lunt via Scopus - Elsevier
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Peer review (3 reviews for 3 publications/grants)

Review activity for Nature (1)
Review activity for Nature communications (1)
Review activity for PloS one. (1)
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