Personal information

Other IDs

Scopus Author ID: 36673321100
Scopus Author ID: 57212763645

Countries

Latvia, United Kingdom

Activities

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Employment (2)

Sitryx Therapeutics Limited: Oxford, GB

2022-04 to present
Employment
Source: Self-asserted source
Marina Makrecka-Kuka

Latvijas Organiskas sintezes instituts: Riga, LV

2008-09 to 2022-03 (Laboratory of Pharmaceutical Pharmacology)
Employment
Source: Self-asserted source
Marina Makrecka-Kuka

Works (33)

Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2025-01 | Journal article
DOI: 10.1016/j.bbadis.2024.167544
Contributors: Luiza H.D. Cardoso; Cristiane Cecatto; Melita Ozola; Stanislava Korzh; Liga Zvejniece; Baiba Gukalova; Carolina Doerrier; Maija Dambrova; Marina Makrecka-Kuka; Erich Gnaiger et al.
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Olaparib Conjugates with Selenopheno[3,2-c]quinolinone Inhibit PARP1 and Reverse ABCB1-Related Multidrug Resistance

Pharmaceutics
2022-11-23 | Journal article
DOI: 10.3390/pharmaceutics14122571
Contributors: Marina Makrecka-Kuka; Jelena Vasiljeva; Pavels Dimitrijevs; Pavel Arsenyan
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Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19

International Journal of Molecular Sciences
2021-12-21 | Journal article
DOI: 10.3390/ijms23010045
Contributors: Reinis Vilskersts; Dana Kigitovica; Stanislava Korzh; Melita Videja; Karlis Vilks; Helena Cirule; Andris Skride; Marina Makrecka-Kuka; Edgars Liepinsh; Maija Dambrova
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Assessment of Iodine and Selenium Nutritional Status in Women of Reproductive Age in Latvia

Medicina
2021-11-05 | Journal article
DOI: 10.3390/medicina57111211
Contributors: Vija Veisa; Ieva Kalere; Tatjana Zake; Ieva Strele; Marina Makrecka-Kuka; Sabine Upmale-Engela; Andrejs Skesters; Dace Rezeberga; Aivars Lejnieks; Iveta Pudule et al.
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Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism

International Journal of Molecular Sciences
2021-06-16 | Journal article
DOI: 10.3390/ijms22126470
Contributors: Karlis Vilks; Melita Videja; Marina Makrecka-Kuka; Martins Katkevics; Eduards Sevostjanovs; Aiga Grandane; Maija Dambrova; Edgars Liepinsh
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Chemical composition of Prunus padus L. flower extract and its anti-inflammatory activities in primary bone marrow-derived macrophages

Journal of Ethnopharmacology
2021-03 | Journal article
DOI: 10.1016/j.jep.2020.113678
Contributors: Inga Sile; Melita Videja; Marina Makrecka-Kuka; Dace Tirzite; Karlis Pajuste; Kirill Shubin; Valerija Krizhanovska; Solveiga Grinberga; Osvalds Pugovics; Maija Dambrova
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Energy substrate metabolism and mitochondrial oxidative stress in cardiac ischemia/reperfusion injury

Free Radical Biology and Medicine
2021-03 | Journal article
DOI: 10.1016/j.freeradbiomed.2021.01.036
Contributors: Maija Dambrova; Coert J. Zuurbier; Vilmante Borutaite; Edgars Liepinsh; Marina Makrecka-Kuka
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Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

Cardiovascular Drugs and Therapy
2020-12-19 | Journal article
DOI: 10.1007/s10557-020-06989-9
Contributors: Marina Makrecka-Kuka; Stanislava Korzh; Melita Videja; Karlis Vilks; Helena Cirule; Janis Kuka; Maija Dambrova; Edgars Liepinsh
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Mitochondrial-Protective Effects of R-Phenibut after Experimental Traumatic Brain Injury

Oxidative Medicine and Cellular Longevity
2020-11-21 | Journal article
DOI: 10.1155/2020/9364598
Contributors: Einars Kupats; Gundega Stelfa; Baiba Zvejniece; Solveiga Grinberga; Edijs Vavers; Marina Makrecka-Kuka; Baiba Svalbe; Liga Zvejniece; Maija Dambrova; Luciano Saso
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Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia

Journal of Cellular and Molecular Medicine
2020-10 | Journal article
DOI: 10.1111/jcmm.15809
Contributors: Marina Makrecka‐Kuka; Stanislava Korzh; Melita Videja; Reinis Vilskersts; Eduards Sevostjanovs; Olga Zharkova‐Malkova; Pavel Arsenyan; Janis Kuka; Maija Dambrova; Edgars Liepinsh
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The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats

Communications Biology
2020-07-17 | Journal article
DOI: 10.1038/s42003-020-1101-3
Contributors: Mitchell E. Allen; Edward Ross Pennington; Justin B. Perry; Sahil Dadoo; Marina Makrecka-Kuka; Maija Dambrova; Fatiha Moukdar; Hetal D. Patel; Xianlin Han; Grahame K. Kidd et al.
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Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from Pelargonium sidoides DC Root Extract

Nutrients
2019-11-19 | Journal article
DOI: 10.3390/nu11112829
Contributors: Aiste Jekabsone; Inga Sile; Andrea Cochis; Marina Makrecka-Kuka; Goda Laucaityte; Elina Makarova; Lia Rimondini; Rasa Bernotiene; Lina Raudone; Evelina Vedlugaite et al.
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Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury

Journal of Molecular and Cellular Cardiology
2019-10 | Journal article
DOI: 10.1016/j.yjmcc.2019.08.010
Contributors: Justin B. Perry; Grace N. Davis; Mitchell E. Allen; Marina Makrecka-Kuka; Maija Dambrova; Robert W. Grange; Saame Raza Shaikh; David A. Brown
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Investigation of Antibacterial and Antiinflammatory Activities of Proanthocyanidins from <em>Pelargonium Sidoides</em> DC Root Extract

2019-09-18 | Other
DOI: 10.20944/preprints201909.0197.v1
Contributors: Aistė Jekabsone; Inga Sile; Andrea Cochis; Marina Makrecka-Kuka; Goda Laucaityte; Elina Makarova; Lia Rimondini; Rasa Bernotiene; Lina Raudone; Evelina Vedlugaite et al.
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Plasma acylcarnitine concentrations reflect the acylcarnitine profile in cardiac tissues

Scientific Reports
2017-12-13 | Journal article
DOI: 10.1038/s41598-017-17797-x
Contributors: Marina Makrecka-Kuka; Eduards Sevostjanovs; Karlis Vilks; Kristine Volska; Unigunde Antone; Janis Kuka; Elina Makarova; Osvalds Pugovics; Maija Dambrova; Edgars Liepinsh
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A cross-sectional survey of urinary iodine status in Latvia

2014 | Journal article
DOI:

10.1016/j.medici.2014.06.003

EID:

2-s2.0-84907012311
Contributors: Konrade, I.; Neimane, L.; Makrecka, M.; Strele, I.; Liepinsh, E.; Lejnieks, A.; Vevere, P.; Gruntmanis, U.; Pirags, V.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria

2014 | Journal article
DOI:

10.1007/s11010-014-2106-3

EID:

2-s2.0-84906318337
Contributors: Makrecka, M.; Kuka, J.; Volska, K.; Antone, U.; Sevostjanovs, E.; Cirule, H.; Grinberga, S.; Pugovics, O.; Dambrova, M.; Liepinsh, E.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Microencapsulation of mildronate in biodegradable and non-biodegradable polymers.

2014 | Journal article
DOI:

10.3109/02652048.2013.834992

PMID:

24124882
Contributors: Loca D; Sevostjanovs E; Makrecka M; Zharkova-Malkova O; Berzina-Cimdina L; Tupureina V; Sokolova M
Source: Self-asserted source
Marina Makrecka-Kuka via Europe PubMed Central

Mildronate, the inhibitor of l-carnitine transport, induces brain mitochondrial uncoupling and protects against anoxia-reoxygenation

2014 | Journal article
DOI:

10.1016/j.ejphar.2013.12.006

EID:

2-s2.0-84890817398
Contributors: Makrecka, M.; Svalbe, B.; Volska, K.; Sevostjanovs, E.; Liepins, J.; Grinberga, S.; Pugovics, O.; Liepinsh, E.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Selective inhibition of OCTN2 is more effective than inhibition of gamma-butyrobetaine dioxygenase to decrease the availability of l-carnitine and to reduce myocardial infarct size

2014 | Journal article
DOI:

10.1016/j.phrs.2014.05.002

EID:

2-s2.0-84902536860
Contributors: Liepinsh, E.; Makrecka, M.; Kuka, J.; Cirule, H.; Makarova, E.; Sevostjanovs, E.; Grinberga, S.; Vilskersts, R.; Lola, D.; Loza, E. et al.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Targeting carnitine biosynthesis: Discovery of new inhibitors against γ-butyrobetaine hydroxylase

2014 | Journal article
DOI:

10.1021/jm401603e

EID:

2-s2.0-84897401258
Contributors: Tars, K.; Leitans, J.; Kazaks, A.; Zelencova, D.; Liepinsh, E.; Kuka, J.; Makrecka, M.; Lola, D.; Andrianovs, V.; Gustina, D. et al.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

The heart is better protected against myocardial infarction in the fed state compared to the fasted state

2014 | Journal article
DOI:

10.1016/j.metabol.2013.09.014

EID:

2-s2.0-84890116705
Contributors: Liepinsh, E.; Makrecka, M.; Kuka, J.; Makarova, E.; Vilskersts, R.; Cirule, H.; Sevostjanovs, E.; Grinberga, S.; Pugovics, O.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Expression and purification of active, stabilized trimethyllysine hydroxylase.

2014-09 | Journal article
PMID:

25220864
Contributors: Kazaks A; Makrecka-Kuka M; Kuka J; Voronkova T; Akopjana I; Grinberga S; Pugovics O; Tars K
Source: Self-asserted source
Marina Makrecka-Kuka via Europe PubMed Central

Activated peroxisomal fatty acid metabolism improves cardiac recovery in ischemia-reperfusion

2013 | Journal article
DOI:

10.1007/s00210-013-0849-0

EID:

2-s2.0-84878015345
Contributors: Liepinsh, E.; Skapare, E.; Kuka, J.; Makrecka, M.; Cirule, H.; Vavers, E.; Sevostjanovs, E.; Grinberga, S.; Pugovics, O.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients

2013 | Journal article
DOI:

10.1016/j.jdiacomp.2012.12.002

EID:

2-s2.0-84876937363
Contributors: Skapare, E.; Konrade, I.; Liepinsh, E.; Strele, I.; Makrecka, M.; Bierhaus, A.; Lejnieks, A.; Pirags, V.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Glyoxalase 1 and 2 enzyme inhibitory activity of 6-sulfamoylsaccharin and sulfocoumarin derivates

2013 | Journal article
DOI:

10.2174/1570180811310050007

EID:

2-s2.0-84879774480
Contributors: Makrecka, M.; Zalubovskis, R.; Vavers, E.; Ivanova, J.; Grandane, A.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

A short-term high-dose administration of sodium pivalate impairs pyruvate metabolism without affecting cardiac function

2012 | Journal article
DOI:

10.1007/s12012-012-9169-8

EID:

2-s2.0-84870538032
Contributors: Kuka, J.; Makrecka, M.; Grinberga, S.; Pugovics, O.; Liepinsh, E.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Glyoxalase 1 and glyoxalase 2 activities in blood and neuronal tissue samples from experimental animal models of obesity and type 2 diabetes mellitus

2012 | Journal article
DOI:

10.1007/s12576-012-0224-9

EID:

2-s2.0-84868550464
Contributors: Skapare, E.; Konrade, I.; Liepinsh, E.; Makrecka, M.; Zvejniece, L.; Svalbe, B.; Vilskersts, R.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Seasonal iodine deficiency in latvian school children

2012 | Journal article
DOI:

10.1089/thy.2011.0506

EID:

2-s2.0-84866984278
Contributors: Konrade, I.; Dambrova, M.; Makrecka, M.; Neimane, L.; Strele, I.; Liepinsh, E.; Lejnieks, A.; Vevere, P.; Gruntmanis, U.; Pirags, V.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

The cardioprotective effect of mildronate is diminished after co-treatment with L-carnitine.

2012 | Journal article
DOI:

10.1177/1074248411419502

EID:

2-s2.0-84867190368
Contributors: Kuka, J.; Vilskersts, R.; Cirule, H.; Makrecka, M.; Pugovics, O.; Kalvinsh, I.; Dambrova, M.; Liepinsh, E.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Anti-diabetic effects of mildronate alone or in combination with metformin in obese Zucker rats

2011 | Journal article
DOI:

10.1016/j.ejphar.2011.02.019

EID:

2-s2.0-79953775086
Contributors: Liepinsh, E.; Skapare, E.; Svalbe, B.; Makrecka, M.; Cirule, H.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Flow cytometric analysis of glyoxalase-1 expression in human leukocytes

2011 | Journal article
DOI:

10.1002/cbf.1723

EID:

2-s2.0-79952220703
Contributors: Skapare, E.; Riekstina, U.; Liepinsh, E.; Konrade, I.; Makrecka, M.; Maurina, B.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier

Mildronate exerts acute anticonvulsant and antihypnotic effects

2010 | Journal article
DOI:

10.1097/FBP.0b013e32833d5a59

EID:

2-s2.0-77955981838
Contributors: Zvejniece, L.; Svalbe, B.; Makrecka, M.; Liepinsh, E.; Kalvinsh, I.; Dambrova, M.
Source: Self-asserted source
Marina Makrecka-Kuka via Scopus - Elsevier
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