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UTI, Catheter-associated urinary tract infection, uropathogens, Enterococcus, E. faecalis, uropathogens, fibrinogen, E. coli, Candida ssp., Inflammation, immune response to infections, Development of antibiotic-sparring therapies

Biography

Dr. Flores-Mireles received her Bachelor degree in Marine Biology at Autonomic University of Baja California Sur (UABCS) in Mexico, followed by a Master degree in Marine Biotechnology in the Center for Biological Research of the Northwest. La Paz, Mexico. Dr. Flores-Mireles did her PhD in Microbiology at Cornell University under Dr. Steve Winans supervision. Then, she did her postdoctoral research at Washington University School of Medicine under Dr. Scott Hultgren and Michael Caparon supervision.

In 2018, she started as her own lab in the Department of Biological Sciences at the University of Notre Dame, where she is currently the Janet C. and Jeffrey A. Hawk Collegiate Associate Professor. Her laboratory is working in understanding how catheter-induced bladder inflammation renders the host susceptible to catheter-associated urinary tract infections and subsequent systemic dissemination. By utilizing a comprehensive approach, combining microbial genetics, transgenic mice, clinical samples, material modification, pathogen and host transcriptomics and proteomics as well as immunological, histological, microscopic, and pharmacological techniques, her lab goals are to develop anti-fouling and biofilm catheters as well as novel antibiotic-sparing therapies against these infections.

Activities

Employment (2)

University of Notre Dame: Notre Dame, Indiana, US

2024-07-01 to present | Janet C. and Jeffrey A. Hawk Collegiate Associate Professor (Biological Sciences)
Employment
Source: Self-asserted source
Ana Flores-Mireles

University of Notre Dame: Notre Dame, IN, US

2018-07-02 to 2024-07-01 | Hawk Assistant Professor (Biological Sciences)
Employment
Source: Self-asserted source
Ana Flores-Mireles

Education and qualifications (4)

Washington University in Saint Louis School of Medicine: Saint Louis, MO, US

2012-06-01 to present | Posdoctoral Researcher (Molecular Microbiology)
Education
Source: Self-asserted source
Ana Flores-Mireles

Cornell University: Ithaca, NY, US

2006-08-25 to 2012-01-04 | PhD Microbiology, Biochemistry and Genetics (Microbiology)
Education
Source: Self-asserted source
Ana Flores-Mireles

Centro de Investigaciónes Biológicas del Noroeste: La Paz, Baja California Sur, MX

2002-08-10 to 2005-11-29 | Master in Science (Marine Microbiology)
Education
Source: Self-asserted source
Ana Flores-Mireles

Universidad Autónoma de Baja California Facultad de Ciencias Humanas: La Paz, Baja California, MX

1998-08-06 to 2002-05-25 | B.S. in Marine Biology (Marine Biology)
Education
Source: Self-asserted source
Ana Flores-Mireles

Funding (2)

Understanding the role of inflammation, fibrinogen and neutrophils in persistence of E. faecalis during CAUTI.

2014-11 to 2017-11 | Grant
NIH Office of the Director (MD, MD, US)
GRANT_NUMBER:

5F32DK104516-02

Source: Self-asserted source
Ana Flores-Mireles

Identification of the host receptor of E. faecalis Ebp pilus

2012-07 to 2013-07 | Award
Washington University in St. Louis (MO, MO, US)
Source: Self-asserted source
Ana Flores-Mireles

Peer review (3 reviews for 2 publications/grants)

Review activity for Mucosal immunology. (1)
Review activity for Nature microbiology. (2)