Personal information

Emails & domains

Verified email addresses

Verified email domains

Websites & social links

Educational python for Neural Networks (EpyNN)
The O-GlcNAc Database
github.com/synthaze
stackoverflow.com/synthaze

Keywords

Biomolecules (RNA, Proteins), Molecular Interactions, Structural Biology and Biophysics, Nuclear Magnetic Resonance, Artificial Intelligence, Programming

Countries

France, Switzerland, United States

Biography

I am a researcher with a substantial background in Biochemistry and Structural Biology, focused on the study of biomolecules and their interactions, especially in the context of RNA splicing. My expertise extends to software development and artificial intelligence, where I have demonstrated significant skills. I am the author of a series of publications in prestigious academic journals, reflecting my work across four distinct affiliations in three different countries: Switzerland (ETH Zurich), the United States (Medical College of Wisconsin), and France (Universities of Paris-Saclay and Bordeaux).

I earned my BSc from the University of Toulouse and am an alumnus of École Normale Supérieure Paris-Saclay, where I completed my MSc training. Subsequently, I was awarded a PhD by Paris-Saclay University. My current focus is on the study of RNA metabolism, aiming to develop innovative approaches for biotechnological and therapeutic applications.

Activities

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Employment (10)

ARNA INSERM U1212 CNRS UMR 5320 - Université de Bordeaux: Bordeaux, FR

2022-03-01 to present | Post-doctoral fellow (Dr. S. Campagne)
Employment
Source: Self-asserted source
Florian Malard

Université de Bordeaux: Bordeaux, FR

2022-09-01 to 2023-05-30 | Teaching Assistant (56h) (Faculty of Biology)
Employment
Source: Self-asserted source
Florian Malard

Medical College of Wisconsin: Milwaukee, Wisconsin, US

2020-03-16 to 2021-12-30 | Post-doctoral fellow (Prof. S. Olivier-Van Stichelen)
Employment
Source: Self-asserted source
Florian Malard

ICSN CNRS UPR 2301 - Université Paris-Saclay: Gif-sur-Yvette, FR

2016-09-01 to 2019-09-30 | PhD Student (Dr. E. Lescop)
Employment
Source: Self-asserted source
Florian Malard

Ecoles doctorales, Université Paris-Saclay: Chatenay-Malabry, FR

2017-09-01 to 2019-06-30 | Teaching Assistant (128h) (Faculty of Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Florian Malard

Université de Versailles Saint-Quentin-en-Yvelines: Versailles, FR

2017-01-02 to 2017-02-28 | Teaching Assistant (18h) (Faculty of Biology)
Employment
Source: Self-asserted source
Florian Malard

BioCIS CNRS UMR 8076 - Université Paris-Saclay: Gif-sur-Yvette, FR

2016-01-02 to 2016-05-30 | Master Thesis (Prof. T. Ha-Duong)
Employment
Source: Self-asserted source
Florian Malard

Institute of Molecular Biology and Biophysics (IMBB) - ETH Zürich: Zürich, CH

2013-09-01 to 2014-07-30 | Research Assistant (Prof. F. Allain)
Employment
Source: Self-asserted source
Florian Malard

IPBS CNRS UMR 5089 - Université Toulouse III: Toulouse, FR

2013-06-01 to 2014-07-30 | Intern (Dr. V. Gervais)
Employment
Source: Self-asserted source
Florian Malard

SPCMIB CNRS UMR 5068 - Université Toulouse III: Toulouse, FR

2012-05-01 to 2012-06-30 | Intern (Dr. M. Baltas & Dr. C. Lherbet )
Employment
Source: Self-asserted source
Florian Malard

Education and qualifications (3)

Ecoles doctorales, Université Paris-Saclay: Gif-sur-Yvette, FR

Doctor of Philosophy (PhD) in "Biochemistry and Structural Biology" (Faculty of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Florian Malard

Ecole Normale Supérieure Paris-Saclay: Gif-sur-Yvette, FR

2013-09-01 to 2016-06-30 | Master of Science (MSc) in "Engineering and Chemistry of Biomolecules" delivered by Université Paris-Saclay (Orsay Faculty of Sciences)
Education
Source: Self-asserted source
Florian Malard

Université Toulouse III - Paul Sabatier: Toulouse, FR

2010-09-01 to 2013-06-30 | Bachelor of Science (BSc) in "Biochemistry and Molecular Biology" (Faculty of Biology)
Education
Source: Self-asserted source
Florian Malard

Professional activities (3)

ARNA: Bordeaux, FR

2022-03-01 to present | Administrator of HPC nodes and website for the SMaRT group (S. Campagne). (PRISM Team, SMaRT group.)
Service
Source: Self-asserted source
Florian Malard

Medical College of Wisconsin: Milwaukee, US

2021-01-01 to present | Development and maintenance of The O-GlcNAc Database. (Department of Biochemistry; Olivier-van Stichelen Lab.)
Service
Source: Self-asserted source
Florian Malard

Science, Technlogy & Health Department Council - Université de Bordeaux: Bordeaux, FR

2023-09-01 to 2024-08-30 | Alternate Member (On behalf of ARNA INSERM U1212)
Membership
Source: Self-asserted source
Florian Malard

Funding (5)

ANR EpiCor AAPG 2024 CE18 (Contributor)

2025-01 to 2028-01 | Grant
ANR (Paris, FR)
Source: Self-asserted source
Florian Malard

Structural and dynamic studies of TCTP protein: deciphering a complex interaction network involved in tumor reversion

2016-10 to 2019-09 | Salary award
Agence Nationale de la Recherche (Paris, FR)
URL: https://theses.hal.science/tel-03091992
Part of GRANT_NUMBER:

ANR-11-IDEX-0003-02
Source: Self-asserted source
Florian Malard

Characterization of the interactions between TCTP and ligands of therapeutic interest

2016-01 to 2016-05 | Salary award
Agence Nationale de la Recherche (Paris, FR)
URL: https://theses.hal.science/tel-03091992
Part of GRANT_NUMBER:

ANR-10-LABX-33
Source: Self-asserted source
Florian Malard

Grant Walter-Zellidja / Académie française for 1 year international research leave

2014-09 to 2015-08 | Salary award
Académie française (Paris, FR)
Source: Self-asserted source
Florian Malard

Merit scolarship from the French Ministry for Higher Education and Research

2013-09 to 2016-06 | Salary award
French Ministry for Higher Education and Research (Paris, FR)
Source: Self-asserted source
Florian Malard

Works (23)

Small Molecules Modulating RNA Splicing: A Review of Targets and Future Perspectives

RSC Medicinal Chemistry
2024 | Review
DOI: 10.1039/d3md00685a
Part of ISSN: 2632-8682
Contributors: Lea Bouton; Agathe Ecoutin; Florian Malard; Sebastien Campagne
Source: Self-asserted source
Florian Malard

The O-GlcNAc database: introducing new features and tools developed from community feedback

Analytical and Bioanalytical Chemistry
2024-10-08 | Journal article
DOI: 10.1007/s00216-024-05571-8
Part of ISSN: 1618-2642
Part of ISSN: 1618-2650
Contributors: Florian Malard; Lilyanna Massman; Sébastien Campagne; Stephanie Olivier-Van Stichelen
Source: Self-asserted source
Florian Malard

1H, 13C and 15N backbone resonance assignment of the calcium-activated EndoU endoribonuclease

Biomolecular NMR Assignments
2024-09-09 | Journal article
DOI: 10.1007/s12104-024-10198-y
Part of ISSN: 1874-2718
Part of ISSN: 1874-270X
Contributors: Florian Malard; Fedor V. Karginov; Sébastien Campagne
Source: Self-asserted source
Florian Malard

Molecular Basis for the Calcium-Dependent Activation of the Ribonuclease EndoU

2024-07-15 | Preprint
DOI: 10.21203/rs.3.rs-4654759/v1
Contributors: Florian Malard; Kristen Dias; Margaux Baudy; Stéphane Thore; Brune Vialet; Philippe Barthelemy; Sébastien Fribourg; Fedor Karginov; Campagne Sebastien
Source: Self-asserted source
Florian Malard

The diversity of splicing modifiers acting on A-1 bulged 5′-splice sites reveals rules for rational drug design

Nucleic Acids Research
2024-03-30 | Journal article
DOI: 10.1093/nar/gkae201
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Florian Malard; Antje C Wolter; Julien Marquevielle; Estelle Morvan; Agathe Ecoutin; Simon H Rüdisser; Frederic Allain; Campagne Sebastien
Source: Self-asserted source
Florian Malard

Studying the O-GlcNAcome of human placentas using banked tissue samples

Glycobiology
2024-01-22 | Journal article
DOI: 10.1093/glycob/cwae005
Part of ISSN: 1460-2423
Contributors: Sarai Luna; Florian Malard; Michaela Pereckas; Mayumi Aoki; Kazahiro Aoki; Stephanie Olivier-Van Stichelen
Source: Self-asserted source
Florian Malard
grade
Preferred source (of 2)‎

Unintentional family poisoning with a chocolate bar with Psilocybe cubensis inside: a case report

Toxicologie Analytique et Clinique
2023-12-15 | Journal article
DOI: 10.1016/j.toxac.2023.12.002
Contributors: Cecile Adamski; Jules-Antoine Vaucel; Camille Paradis; Clément Brunet; Audrey Nardon; Arnaud Courtois; Florian Malard; Nadège Castaing; Magali Labadie
Source: Self-asserted source
Florian Malard

Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

Nature Communications
2023-09-04 | Journal article
DOI: 10.1038/s41467-023-40254-5
Part of ISSN: 2041-1723
Contributors: Campagne Sebastien; Daniel Jutzi; Florian Malard; Maja Matoga; Ksenija Romane; Miki Feldmuller; Martino Colombo; Marc-David Ruepp; Frederic Allain
Source: Self-asserted source
Florian Malard

Structural transitions in TCTP tumor protein upon binding to the anti-apoptotic protein family member Mcl-1

Journal of Biological Chemistry
2023-07 | Journal article | Author
DOI: 10.1016/j.jbc.2023.104830
Part of ISSN: 0021-9258
Contributors: Florian Malard; Christina Sizun; Aurelien Thureau; Ludovic Carlier; Ewen Lescop
Source: Self-asserted source
Florian Malard
grade
Preferred source (of 2)‎

Non-Nutritive Sweeteners Acesulfame Potassium and Sucralose Are Competitive Inhibitors of the Human P-glycoprotein/Multidrug Resistance Protein 1 (PGP/MDR1)

Nutrients
2023-02 | Journal article | Author
DOI: 10.3390/nu15051118
Contributors: Laura Danner; Florian Malard; Raquel Valdes; Stephanie Olivier-Van Stichelen
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

EpyNN: Educational python for Neural Networks

SoftwareX
2022 | Journal article
DOI: 10.1016/j.softx.2022.101140
EID:

2-s2.0-85133927427

Part of ISSN: 23527110
Contributors: Malard, F.; Danner, L.; Rouzies, E.; Meyer, J.G.; Lescop, E.; Olivier-Van Stichelen, S.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier
grade
Preferred source (of 2)‎

Principles and correction of 5’-splice site selection

RNA Biology
2022-12-31 | Review
DOI: 10.1080/15476286.2022.2100971
Part of ISSN: 1547-6286
Part of ISSN: 1555-8584
Contributors: Florian Malard; Cameron Mackereth; Sébastien Campagne
Source: Self-asserted source
Florian Malard
grade
Preferred source (of 3)‎

Find out if your protein is O‐GlcNAc modified: The O‐GlcNAc database

The FASEB Journal
2022-05 | Conference abstract
DOI: 10.1096/fasebj.2022.36.s1.r4178
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Contributors: Stéphanie Olivier-Van Stichelen; Florian Malard; Rex Berendt; Eugenia Wulff-Fuentes; Laura Danner
Source: Self-asserted source
Florian Malard

Revisiting the Molecular Interactions between the Tumor Protein TCTP and the Drugs Sertraline/Thioridazine

ChemMedChem
2022-01-05 | Journal article | Author
DOI: 10.1002/cmdc.202100528
Part of ISSN: 1860-7179
Part of ISSN: 1860-7187
Contributors: Florian Malard; Eric JACQUET; Naima Nhiri; Christina Sizun; Amélie Chabrier; Samir MESSAOUDI; Jérôme DEJEU; Stephane Betzi; Xu Zhang; Aurelien Thureau et al.
Source: Self-asserted source
Florian Malard
grade
Preferred source (of 2)‎

An in vitro reconstituted U1 snRNP allows the study of the disordered regions of the particle and the interactions with proteins and ligands

Nucleic Acids Research
2021 | Journal article
DOI: 10.1093/nar/gkab135
EID:

2-s2.0-85109053389

Part of ISSN: 13624962 03051048
Contributors: Campagne, S.; De Vries, T.; Malard, F.; Afanasyev, P.; Dorn, G.; Dedic, E.; Kohlbrecher, J.; Boehringer, D.; Cléry, A.; Allain, F.H.-T.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier

Automatization and self-maintenance of the O-GlcNAcome catalog: A smart scientific database

Database
2021 | Journal article
DOI: 10.1093/database/baab039
EID:

2-s2.0-85111799484

Part of ISSN: 17580463
Contributors: Malard, F.; Wulff-Fuentes, E.; Berendt, R.R.; Didier, G.; Olivier-Van Stichelen, S.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier

Drimane Derivatives as the First Examples of Covalent BH3 Mimetics that Target MCL-1

ChemMedChem
2021 | Journal article
DOI: 10.1002/cmdc.202100011
EID:

2-s2.0-85102855126

Part of ISSN: 18607187 18607179
Contributors: Daressy, F.; Malard, F.; Seguy, L.; Guérineau, V.; Apel, C.; Dumontet, V.; Robert, A.; Groo, A.-C.; Litaudon, M.; Bignon, J. et al.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier

The human O-GlcNAcome database and meta-analysis

Scientific Data
2021 | Journal article
DOI: 10.1038/s41597-021-00810-4
EID:

2-s2.0-85099969999

Part of ISSN: 20524463
Contributors: Wulff-Fuentes, E.; Berendt, R.R.; Massman, L.; Danner, L.; Malard, F.; Vora, J.; Kahsay, R.; Olivier-Van Stichelen, S.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier

The O-GlcNAc database

GLYCOBIOLOGY
2021-12-01 | Book chapter
Contributors: Florian Malard; Eugenia Wulff; Rex Berendt; Stéphanie Olivier-Van Stichelen
Source: Self-asserted source
Florian Malard

Automatization and Self‐Maintenance of the O‐GlcNAcome catalogue: A Smart Scientific Database

The FASEB Journal
2021-05 | Conference abstract
DOI: 10.1096/fasebj.2021.35.s1.02916
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Contributors: Florian Malard; Eugenia Wulff-Fuentes; Rex Berendt; Stéphanie Olivier-Van Stichelen
Source: Self-asserted source
Florian Malard

Structural and dynamic studies of TCTP protein : deciphering a complex interaction network involved in tumor reversion

2019-12-03 | Report
HAL: tel-03091992
Contributors: Florian Malard
Source: Self-asserted source
Florian Malard
grade
Preferred source (of 2)‎

Conformational Ensemble and Biological Role of the TCTP Intrinsically Disordered Region: Influence of Calcium and Phosphorylation

Journal of Molecular Biology
2018 | Journal article
DOI: 10.1016/j.jmb.2018.04.024
EID:

2-s2.0-85046826283

Part of ISSN: 10898638 00222836
Contributors: Malard, F.; Assrir, N.; Alami, M.; Messaoudi, S.; Lescop, E.; Ha-Duong, T.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier

Structural insights into TCTP and its interactions with ligands and proteins

Results and Problems in Cell Differentiation
2017 | Book chapter
DOI: 10.1007/978-3-319-67591-6_2
EID:

2-s2.0-85034830563

Part of ISSN: 18610412 00801844
Contributors: Assrir, N.; Malard, F.; Lescop, E.
Source: Self-asserted source
Florian Malard via Scopus - Elsevier
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