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coenzyme Q, methyltransferase, aging, mitochondria, coenzyme Q biosynthesis
United States

Biography

I am a PhD candidate in the labs of Catherine F. Clarke and Steven G. Clarke at UCLA. My research interests include antioxidants (specifically coenzyme Q), aging, and cellular repair. As an undergraduate, I studied the mechanism of organocatalytic reactions using density functional theory methods under the mentorship of Prof. Ken Houk. In my PhD program, I continue to apply a combination of computational and experimental techniques to solve problems in biochemistry. I currently work on elucidating the molecular mechanism and structure-function relationship of COQ5, a methyltransferase involved in coenzyme Q biosynthesis, in the context of pathogenic single nucleotide variants in humans. I use a wide range of approaches, both computational and biochemical, with the yeast S. cerevisiae as a primary model organism. I also hope to develop an in vitro radioactive methyltransferase assay for yeast Coq5, in order to study the effect of point mutations.

Activities

Works (3)

Predicting and Understanding the Pathology of Single Nucleotide Variants in Human COQ Genes

Antioxidants
2022-11-22 | Journal article
Contributors: Sining Wang; Akash Jain; Noelle Alexa Novales; Audrey N. Nashner; Fiona Tran; Catherine F. Clarke
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Crossref
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Efficient synthesis of isoindolones by intramolecular cyclisation of pyridinylbenzoic acids

Organic & Biomolecular Chemistry
2021 | Journal article
Contributors: Atena B. Solea; Sining Wang; Xiao-Song Xue; Aurelien Crochet; Katharina M. Fromm; Kendall N. Houk; Olimpia Mamula; Christophe Allemann
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Origins of Contrasteric π-Facial Selectivity in Epoxidations of Encumbered Tetrahydropyridines by a Bifunctional Peracid

Synlett
2019-01 | Journal article
Part of ISSN: 0936-5214
Part of ISSN: 1437-2096
Source: Self-asserted source
Sining Wang