Personal information

United States

Activities

Education and qualifications (3)

Harvard Medical School: Boston, Massachusetts, US

2016-06 to present | MD
Education
Source: Self-asserted source
Brian Do

Massachusetts Institute of Technology: Cambridge, MA, US

2018-09 to 2023-08 | PhD (Medical Engineering and Medical Physics)
Education
Source: Self-asserted source
Brian Do

Stanford University: Stanford, California, US

2012-09 to 2016-06 | B.S. (Computer Science and Biology)
Education
Source: Self-asserted source
Brian Do

Works (17)

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

Developmental Cell
2024-08 | Journal article
Contributors: Brian T. Do; Peggy P. Hsu; Sidney Y. Vermeulen; Zhishan Wang; Taghreed Hirz; Keene L. Abbott; Najihah Aziz; Joseph M. Replogle; Stefan Bjelosevic; Jonathan Paolino et al.
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Crossref

Cancer tissue of origin constrains the growth and metabolism of metastases

Nature Metabolism
2024-08-19 | Journal article
Contributors: Sharanya Sivanand; Yetis Gultekin; Peter S. Winter; Sidney Y. Vermeulen; Konstantine M. Tchourine; Keene L. Abbott; Laura V. Danai; Florian Gourgue; Brian T. Do; Kayla Crowder et al.
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Crossref

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

2022-08-16 | Preprint
Contributors: Brian T. Do; Peggy P. Hsu; Sidney Y. Vermeulen; Zhishan Wang; Taghreed Hirz; Keene L. Abbott; Najihah Aziz; Joseph M. Replogle; Stefan Bjelosevic; Jonathan Paolino et al.
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Crossref

Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity

Nature Communications
2022-04-29 | Journal article
Contributors: Reuben Franklin; Yiming Guo; Shiyang He; Meijuan Chen; Fei Ji; Xinyue Zhou; David Frankhouser; Brian T. Do; Carmen Chiem; Mihyun Jang et al.
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Crossref

Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells

Nature Metabolism
2021-06-21 | Journal article
Contributors: Andrew J. Schwartz; Joshua W. Goyert; Sumeet Solanki; Samuel A. Kerk; Brandon Chen; Cristina Castillo; Peggy P. Hsu; Brian T. Do; Rashi Singhal; Michael K. Dame et al.
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Crossref

Cell-programmed nutrient partitioning in the tumour microenvironment

Nature
2021-05-13 | Journal article
Contributors: Bradley I. Reinfeld; Matthew Z. Madden; Melissa M. Wolf; Anna Chytil; Jackie E. Bader; Andrew R. Patterson; Ayaka Sugiura; Allison S. Cohen; Ahmed Ali; Brian T. Do et al.
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Crossref

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

2020-08-10 | Preprint
Contributors: BI Reinfeld; MZ Madden; MM Wolf; A Chytil; JE Bader; AR Patterson; AS Cohen; A Ali; BT Do; A Muir et al.
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Crossref

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

bioRxiv
2020-06-09 | Journal article
Source: Self-asserted source
Brian Do

The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders.

eLife
2019-01-10 | Journal article
Source: Self-asserted source
Brian Do

Opportunities and obstacles for deep learning in biology and medicine

Journal of The Royal Society Interface
2018-04-30 | Journal article
Contributors: Travers Ching; Daniel S. Himmelstein; Brett K. Beaulieu-Jones; Alexandr A. Kalinin; Brian T. Do; Gregory P. Way; Enrico Ferrero; Paul-Michael Agapow; Michael Zietz; Michael M. Hoffman et al.
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Crossref

Opportunities and obstacles for deep learning in biology and medicine

2017-05-28 | Preprint
Contributors: Travers Ching; Daniel S. Himmelstein; Brett K. Beaulieu-Jones; Alexandr A. Kalinin; Brian T. Do; Gregory P. Way; Enrico Ferrero; Paul-Michael Agapow; Michael Zietz; Michael M. Hoffman et al.
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Crossref

irCLIP platform for efficient characterization of protein-RNA interactions.

2016-06 | Journal article
Contributors: Zarnegar BJ; Flynn RA; Shen Y; Do BT; Chang HY; Khavari PA
Source: Self-asserted source
Brian Do via Europe PubMed Central

Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress.

2016-05 | Journal article
Contributors: Oh S; Flynn RA; Floor SN; Purzner J; Martin L; Do BT; Schubert S; Vaka D; Morrissy S; Li Y et al.
Source: Self-asserted source
Brian Do via Europe PubMed Central

Stress from Nucleotide Depletion Activates the Transcriptional Regulator HEXIM1 to Suppress Melanoma.

2016-04 | Journal article
Contributors: Tan JL; Fogley RD; Flynn RA; Ablain J; Yang S; Saint-André V; Fan ZP; Do BT; Laga AC; Fujinaga K et al.
Source: Self-asserted source
Brian Do via Europe PubMed Central

7SK-BAF axis controls pervasive transcription at enhancers.

2016-03 | Journal article
Contributors: Flynn RA; Do BT; Rubin AJ; Calo E; Lee B; Kuchelmeister H; Rale M; Chu C; Kool ET; Wysocka J et al.
Source: Self-asserted source
Brian Do via Europe PubMed Central

Dissecting noncoding and pathogen RNA-protein interactomes.

2015-01 | Journal article
Contributors: Flynn RA; Martin L; Spitale RC; Do BT; Sagan SM; Zarnegar B; Qu K; Khavari PA; Quake SR; Sarnow P et al.
Source: Self-asserted source
Brian Do via Europe PubMed Central

Dicer-microRNA-Myc circuit promotes transcription of hundreds of long noncoding RNAs.

2014-07 | Journal article
Contributors: Zheng GX; Do BT; Webster DE; Khavari PA; Chang HY
Source: Self-asserted source
Brian Do via Europe PubMed Central