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Medikine, Inc.
ResearchGate

Biography

2022-Present. Scientific Advisor, Medikine, Inc. Menlo Park, CA
2010-2022 Founder and Chief Scientific Officer; Medikine, Inc. Menlo Park, CA
2008-2009 XenoPort Fellow; XenoPort, Inc. Santa Clara, CA
1999-2008 Founder and Vice President, Discovery Biology; XenoPort, Inc. Santa Clara, CA
1995-1999 Senior Director, Molecular Biology; Affymax Research Institute, Palo Alto, CA.
1992-1994 Director of Molecular Biology: Affymax Research Institute Palo Alto, CA
1991–1992 Senior Scientist, Molecular Biology; Affymax Research Institute, Palo Alto, CA
1989–1990 Staff Scientist, Molecular Biology; Affymax Research Institute, Palo Alto, CA
1984-1989 Senior Research Biochemist and Project Scientist; Bio-Rad Laboratories, Richmond, CA
1982–1983 Research Associate, Biological Sciences; Stanford University, Stanford, CA
1978–1981 Postdoctoral Research Fellow, Biological Sciences; Stanford University, Stanford, CA (Dr. R. T. Schimke).
1973–1977 Graduate Student, Reproductive Biology; Harvard Medical School, Boston, MA (Dr. K.J. Ryan)
1971–1973 Graduate Student, Biology; University of California, San Diego, CA (Dr K.J. Ryan)
1970 –1971 Research Assistant, Reproductive Medicine; School of Medicine, University of California, San Diego, CA

US Patents (most recent 25)

50) US 7,037,706 Ronald W Barrett;. William J. Dower; Mark Gallop; Thomas F. Woiwode; Steven E. Cwirla; Compounds displayed on replicable genetic packages and methods of using same. May 2, 2006. (XenoPort)

51) US 7,056,666 William J Dower, Stephen PA Fodor. Analysis of surface immobilized polymers utilizing microfluorescence detection. June 6, 2006. (Affymetrix)

52) US 7,091,311. William J. Dower; Barrett; Ronald W. Cwirla; Steven E. Duffin; David J., Gates; Christian M. Haselden; Sherril S. Mattheakis; Larry C.,Schatz; Peter J., Wagstrom; Christopher R. Wrighton; Nicholas C. Peptides and compounds that bind to a receptor. August 15, 2006. (Affymax)

53) US 7,192,720. William J Dower; Cwirla, Steven E. Array-based, epitope-captured antibody display. March 20, 2007. (XenoPort)

54) US 7,229,757. Barrett; Ronald W. William J Dower; Gallop; Mark; Woiwode; Thomas F. Cwirla, Steven E. Compounds displayed on icosahedral phage and methods of using same. June 12, 2007. (XenoPort)

55) US7,329,496. William J Dower, Stephen PA Fodor. Sequencing of surface immobilized polymers utilizing microflourescence detection. Feb 12, 2008. (Affymetrix)

56) US 7,413,536. William J. Dower, Mark A. Gallop; Ronald W. Barrett; Kenneth C. Cundy; Tania Chernov-Rogan. Substrates and screening methods for transport proteins. Aug. 19, 2008. (XenoPort)

57) US 7,459,275. Willliam J. Dower, Stephen SPA Fodor. Sequencing of surface immobilized polymers utilizing microfluorescence detection. Dec 2, 2008. (Affymetrix)

58) US 7,507,546. Noa Zerangue; Tracy Dias; William J. Dower; Methods of screening agents, conjugates or conjugate moieties for transport by a PEPT2 transporter. Mar. 24, 2009. (XenoPort)

59) US 7,517,643. Ronald W. Barrett; William J. Dower; Mark Gallop; Thomas F. Woiwode Steven E. Cwirla. Compounds displayed on replicable genetic packages and methods of using same. Apr. 14, 2009. (XenoPort)

60) US 7,534,574. William J. Dower; Steven E. Cwirla. Epitope-captured antibody display. May 19, 2009. (XenoPort)

61) US 7,553,617. William J. Dower, Steven E Cwirla. Peptide library and screening systems. .un 30, 2009. (Affymax)

62) US 7,683,043. Noa Zerangue, Qingzhi Gao, William J. Dower. Creatine phosphate analog prodrugs, compositions and uses therof. Mar 23, 2010. (XenoPort)

63) US 7,741,062. William J Dower, Steven E Cwirla. Epitope-captured antibody display. Jun. 22, 2010. (XenoPort)

64) US 7,919,454. Noa Zerangue, Tracy Dias, William J Dower. Methods of treatment using conjugates transported by a PEPT2 transporter. April 5, 2011. (XenoPort)

65) US 8,202,852. Noa Zerangue, Quingzhi Gao, William J Dower. Creatine phosphate analog pro-drugs, compositions and uses thereof. June 19, 2012. (Affymax/GSK)

66) US 8,227,422. William J Dower, Ronald W Barrett, Steven W Cwirla, David J Duffin, Christian M Gates, Sherril S Haselden, Larry C Mattheakis, Peter J Schatz, Christopher R Wagstrom, Nicholas,C Wrighton. Peptides and compounds that bind to a receptor. July 24, 2012.

67) US10,689,417-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2R.gamma binding compounds. June 23, 2020

68) US10,703,776-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2R beta binding compounds. July 7, 2020

69) US11,248,025-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. IL-2alpha receptor subunit binding compounds. Feb 15, 2022 (Medikine

70) US11,248,030-B2. William J Dower, Michael C Needels, Ronald W Barrett, Alice V. Bakker, Steven E Cwirla. Dual IL-2R and IL-7R binding

Activities

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Employment (10)

Medikine, Inc: Menlo Park, California, US

2022 to present | Co-Founder and Scientific Advisor
Employment
Source: Self-asserted source
William J. Dower

Medikine, Inc: Menlo Park, California, US

2012 to 2022 | Co-Founder and Chief Scientific Officer (Research)
Employment
Source: Self-asserted source
William J. Dower

Xenoport, Inc: Santa Clara, California, US

1998 to 2009 | Co-Founder and Vice President (Discovery Biology)
Employment
Source: Self-asserted source
William J. Dower

Affymax Research Institute: Palo Alto, California, US

1989 to 1999 | Senior Director (Cell and Molecular Biology)
Employment
Source: Self-asserted source
William J. Dower

BioRad Laboratories: Richmond, CA, US

1984 to 1989 | Senior Research Biochemist and Project Scientist (Research)
Employment
Source: Self-asserted source
William J. Dower

Stanford University: Stanford, CA, US

1982 to 1983 | Research Associate, (Biological Sciences)
Employment
Source: Self-asserted source
William J. Dower

Stanford University: Stanford, CA, US

1978 to 1981 | Postdoctoral Research Fellow (Biological Sciences)
Employment
Source: Self-asserted source
William J. Dower

Harvard Medical School: Boston, MA, US

1973 to 1978 | Graduate student (Reproductive Biology)
Employment
Source: Self-asserted source
William J. Dower

University of California San Diego School of Medicine: La Jolla, CA, US

1971 to 1973 | Graduate student (Biology)
Employment
Source: Self-asserted source
William J. Dower

University of California San Diego School of Medicine: La Jolla, CA, US

1970 to 1971 | Research Assistant (Reproductive Medicine)
Employment
Source: Self-asserted source
William J. Dower

Education and qualifications (4)

Stanford University: Stanford, California, US

1982 to 1983 | Research Associate (Biological Sciences)
Education
Source: Self-asserted source
William J. Dower

Stanford University: Stanford, California, US

1978 to 1981 | Postdoctoral Fellow (Biological Sciences)
Education
Source: Self-asserted source
William J. Dower

University of California, San Diego: La Jolla, CA, US

1977 | PhD (Biology)
Education
Source: Self-asserted source
William J. Dower

University of California, San Diego: La Jolla, CA, US

1970 | BA (Biology)
Education
Source: Self-asserted source
William J. Dower

Works (49)

A mechanistically novel peptide agonist of the IL-7 receptor that addresses limitations of IL-7 cytokine therapy

2023-05-24 | Preprint
DOI: 10.1101/2023.05.24.542196
Contributors: William J. Dower; Angie Inkyung Park; Alice V. Bakker; Steven E. Cwirla; Praechompoo Pongtornpipat; Blake M. Williams; Prarthana Joshi; Bryan A. Baxter; Michael C. Needels; Ronald W. Barrett
Source: check_circle
Crossref
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Preferred source (of 2)‎

1097 MDK1654: a branched synthetic peptide that activates both the IL-7 receptor and the βγc form of the IL-2/15 receptor

Regular and Young Investigator Award Abstracts
2022-11 | Conference poster
DOI: 10.1136/jitc-2022-sitc2022.1097
Contributors: Inkyung Angie Park; Steven Cwirla; Alice Bakker; Ronald Barrett; Michael Needels; Praechompoo Pongtornpipat; Blake Williams; Prarthana Joshi; William Dower
Source: Self-asserted source
William J. Dower

Abstract 2066: In vitro and in vivo properties of MDK703: An Fc-peptide fusion IL-7Rαγc agonist unrelated in structure to IL-7

Cancer Research
2022-06-15 | Conference poster
DOI: 10.1158/1538-7445.am2022-2066
Part of ISSN: 1538-7445
Contributors: Angie I. Park; Steven E. Cwirla; Alice V. Bakker; Blake M. Williams; Prarthana Joshi; Praechompoo Pongtornpipat; Bryan Baxter; Michael C. Needels; Ronald W. Barrett; William J. Dower
Source: Self-asserted source
William J. Dower

567 MDK1319/MDK-701: A potent fully efficacious peptidyl agonist of IL-7Rαγc, designed with no reference to cytokine or receptor structure and unrelated to IL-7, fused to an Fc-domain for PK enhancement

Regular and young investigator award abstracts
2020-11 | Conference poster
DOI: 10.1136/jitc-2020-sitc2020.0567
Contributors: William Dower; Alice Bakker; Steven Cwirla; Prarthana Joshi; Praechompoo Pongtornpipat; Blake Williams; Sandra Wang; Michael Needels; Ronald Barrett
Source: Self-asserted source
William J. Dower

691 MDK-271: A dual function molecule consisting of empirically-designed peptidyl agonists of IL-2/15Rβγc and IL-7Rαγc, unrelated to IL-2, IL-15, or IL-7, incorporated into a bispecific Fc fusion protein

Regular and young investigator award abstracts
2020-11 | Conference poster
DOI: 10.1136/jitc-2020-sitc2020.0691
Contributors: William Dower; Steven Cwirla; Alice Bakker; Praechompoo Pongtornpipat; Blake Williams; Prarthana Joshi; Sandra Wang; Michael Needels; Ronald Barrett
Source: Self-asserted source
William J. Dower

MK1169, a peptide unrelated to IL-2, is a potent IL-2Rbgc agonist

SITC 2019 Annual Meeting
2019 | Conference poster
Contributors: William J. Dower; Steven E. Cwirla; Blake M. Williams; Praechompoo Pongtornpipat; Prarthana Joshi; Sandra M. Wang; Alice V. Bakker; Michael C. Needels; Ronald W. Barrett
Source: Self-asserted source
William J. Dower

Creating Vast Peptide Expression Libraries: Electroporation as a Tool to Construct Plasmid Libraries of Greater than 10<sup>9</sup> Recombinants

Guide to Electroporation and Electrofusion
2012 | Book chapter
Part of DOI: 10.1016/B978-0-08-091727-6.50021-6
EID:

2-s2.0-84940916425
Contributors: Dower, W.J.; Cwirla, S.E.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Electrotransformation of Bacteria by Plasmid DNA

Guide to Electroporation and Electrofusion
2012 | Book chapter
Part of DOI: 10.1016/B978-0-08-091727-6.50020-4
EID:

2-s2.0-84940927040
Contributors: Trevors, J.T.; Chassy, B.M.; Dower, W.J.; Blaschek, H.P.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Protocols for the Transformation of Bacteria by Electroporation

Guide to Electroporation and Electrofusion
2012 | Book chapter
Part of DOI: 10.1016/B978-0-08-091727-6.50033-2
EID:

2-s2.0-84940905189
Contributors: Dower, W.J.; Chassy, B.M.; Trevors, J.T.; Blaschek, H.P.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

Pharmacological Research
2009 | Journal article
DOI: 10.1016/j.phrs.2009.02.007
EID:

2-s2.0-65049090941

Part of ISSN: 10436618 10961186
Contributors: Warren, M.S.; Zerangue, N.; Woodford, K.; Roberts, L.M.; Tate, E.H.; Feng, B.; Li, C.; Feuerstein, T.J.; Gibbs, J.; Smith, B. et al.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Synthetic compound libraries displayed on the surface of encoded bacteriophage

Chemistry and Biology
2003 | Journal article
DOI: 10.1016/j.chembiol.2003.08.005
EID:

2-s2.0-0141856609

Part of ISSN: 10745521
Contributors: Woiwode, T.F.; Haggerty, J.E.; Katz, R.; Gallop, M.A.; Barrett, R.W.; Dower, W.J.; Cwirla, S.E.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

In vitro selection as a powerful tool for the applied evolution of proteins and peptides

Current Opinion in Chemical Biology
2002 | Journal article
DOI: 10.1016/S1367-5931(02)00332-0
EID:

2-s2.0-0036603593

Part of ISSN: 13675931
Contributors: Dower, W.J.; Mattheakis, L.C.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Expression of extracellular N-terminal domain of NMDA receptor in mammalian cells.

Methods in molecular biology (Clifton, N.J.)
1999 | Journal article
DOI: 10.1385/1-59259-683-5:61
EID:

2-s2.0-0032611132

Part of ISSN: 10643745
Contributors: Whitehorn, E.A.; Dower, W.J.; Li, M.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

In vitro selection of peptides acting on NMDA receptors.

Methods in molecular biology (Clifton, N.J.)
1999 | Journal article
DOI: 10.1385/1-59259-683-5:131
EID:

2-s2.0-0032618469

Part of ISSN: 10643745
Contributors: Cwirla, S.E.; Dower, W.J.; Li, M.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Peptide mimetics of growth factors selected from diverse peptide libraries

American Chemical Society, Polymer Preprints, Division of Polymer Chemistry
1999 | Conference paper
EID:

2-s2.0-0033095288

Part of ISSN: 00323934
Contributors: Dower, William J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1

Biochemistry
1998 | Journal article
DOI: 10.1021/bi971956y
EID:

2-s2.0-0032539954

Part of ISSN: 00062960
Contributors: Johnson, D.L.; Farrell, F.X.; Barbone, F.P.; McMahon, F.J.; Tullai, J.; Hoey, K.; Livnah, O.; Wrighton, N.C.; Middleton, S.A.; Loughney, D.A. et al.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Identification of peptide ligands for the antigen binding receptor expressed on human B-cell lymphomas.

Methods in molecular biology (Clifton, N.J.)
1998 | Journal article
EID:

2-s2.0-0031605949

Part of ISSN: 10643745
Contributors: Renschler, M.F.; Dower, W.J.; Levy, R.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Peptide agonists of the thrombopoietin receptor.

Stem cells (Dayton, Ohio)
1998 | Journal article
DOI: 10.1002/stem.5530160705
EID:

2-s2.0-0032228104

Part of ISSN: 10665099
Contributors: Dower, W.J.; Cwirla, S.E.; Balasubramanian, P.; Schatz, P.J.; Baccanari, D.P.; Barrett, R.W.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Targeting growth factor and cytokine receptors with recombinant peptide libraries

Current Opinion in Chemical Biology
1998 | Journal article
DOI: 10.1016/S1367-5931(98)80005-7
EID:

2-s2.0-0032086337

Part of ISSN: 13675931
Contributors: Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Increased potency of an erythropoietin peptide mimetic through covalent dimerization

Nature Biotechnology
1997 | Journal article
DOI: 10.1038/nbt1197-1261
EID:

2-s2.0-0030717635

Part of ISSN: 15461696 10870156
Contributors: Wrighton, N.C.; Balasubramanian, P.; Barbone, F.P.; Kashyap, A.K.; Farrell, F.X.; Jolliffe, L.K.; Barrett, R.W.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine

Science
1997 | Journal article
DOI: 10.1126/science.276.5319.1696
EID:

2-s2.0-0030773876

Part of ISSN: 00368075
Contributors: Cwirla, S.E.; Balasubramanian, P.; Duffin, D.J.; Wagstrom, C.R.; Gates, C.M.; Singer, S.C.; Davis, A.M.; Tansik, R.L.; Mattheakis, L.C.; Boytos, C.M. et al.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Random peptide libraries as a source of functional peptide ligands of growth factor receptors

FASEB Journal
1997 | Journal article
EID:

2-s2.0-33750136291

Part of ISSN: 08926638
Contributors: Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Cell-free synthesis of peptide libraries displayed on polysomes

Methods in Enzymology
1996 | Book
DOI: 10.1016/s0076-6879(96)67013-x
EID:

2-s2.0-0029693534

Part of ISSN: 00766879
Contributors: Mattheakis, L.C.; Dias, J.M.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 Å

Science
1996 | Journal article
DOI: 10.1126/science.273.5274.464
EID:

2-s2.0-0029798402

Part of ISSN: 00368075
Contributors: Livnah, O.; Stura, E.A.; Johnson, D.L.; Middleton, S.A.; Mulcahy, L.S.; Wrighton, N.C.; Dower, W.J.; Jolliffe, L.K.; Wilson, I.A.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries

Proceedings of the National Academy of Sciences of the United States of America
1996 | Journal article
DOI: 10.1073/pnas.93.14.7381
EID:

2-s2.0-0011958990

Part of ISSN: 00278424
Contributors: Yanofsky, S.D.; Baldwin, D.N.; Butler, J.H.; Holden, F.R.; Jacobs, J.W.; Balasubramanian, P.; Chinn, J.P.; Cwirla, S.E.; Peters-Bhatt, E.; Whitehorn, E. et al.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Small peptides as potent mimetics of the protein hormone erythropoietin

Science
1996 | Journal article
DOI: 10.1126/science.273.5274.458
EID:

2-s2.0-9444236174

Part of ISSN: 00368075
Contributors: Wrighton, N.C.; Farrell, F.X.; Chang, R.; Kashyap, A.K.; Barbone, F.P.; Mulcahy, L.S.; Johnson, D.L.; Barrett, R.W.; Jolliffe, L.K.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Toward cell-targeting gene therapy vectors: Selection of cell-binding peptides from random peptide-presenting phage libraries

Nature Medicine
1996 | Journal article
DOI: 10.1038/nm0396-299
EID:

2-s2.0-0029880651

Part of ISSN: 10788956
Contributors: Barry, M.A.; Dower, W.J.; Johnston, S.A.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

A generic method for expression and use of “Tagged” soluble versions of cell surface receptors

Bio/Technology
1995 | Journal article
DOI: 10.1038/nbt1195-1215
EID:

2-s2.0-0028843867

Part of ISSN: 0733222X
Contributors: Whitehorn, E.A.; Tate, E.; Yanofsky, S.D.; Kochersperger, L.; Davis, A.; Mortensen, R.B.; Yonkovich, S.; Bell, K.; Dower, W.J.; Barrett, R.W.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Peptides which bind to E-selectin and block neutrophil adhesion

Journal of Biological Chemistry
1995 | Journal article
DOI: 10.1074/jbc.270.36.21129
EID:

2-s2.0-0029135427

Part of ISSN: 00219258
Contributors: Martens, C.L.; Cwirla, S.E.; Lee, R.Y.-W.; Whitehorn, E.; Chen, E.Y.-F.; Bakker, A.; Martin, E.L.; Wagstrom, C.; Gopalan, P.; Smith, C.W. et al.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

An in vitro polysome display system for identifying ligands from very large peptide libraries

Proceedings of the National Academy of Sciences of the United States of America
1994 | Journal article
DOI: 10.1073/pnas.91.19.9022
EID:

2-s2.0-0028592703

Part of ISSN: 00278424
Contributors: Mattheakis, L.C.; Bhatt, R.R.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

Journal of Medicinal Chemistry
1994 | Journal article
DOI: 10.1021/jm00035a001
EID:

2-s2.0-0028243847

Part of ISSN: 15204804 00222623
Contributors: Gallop, M.A.; Barrett, R.W.; Dower, W.J.; Fodor, S.P.A.; Gordon, E.M.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

Journal of Medicinal Chemistry
1994 | Journal article
DOI: 10.1021/jm00036a001
EID:

2-s2.0-0028318863

Part of ISSN: 15204804 00222623
Contributors: Gordon, E.M.; Barrett, R.W.; Dower, W.J.; Fodor, S.P.A.; Gallop, M.A.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Membrane insertion defects caused by positive charges in the early mature region of protein pIII of filamentous phage fd can be corrected by prlA suppressors

Journal of Bacteriology
1994 | Journal article
DOI: 10.1128/jb.176.14.4296-4305.1994
EID:

2-s2.0-0028308297

Part of ISSN: 00219193
Contributors: Peters, E.A.; Schatz, P.J.; Johnson, S.S.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Synthetic peptide ligands of the antigen binding receptor induce programmed cell death in a human B-cell lymphoma

Proceedings of the National Academy of Sciences of the United States of America
1994 | Journal article
DOI: 10.1073/pnas.91.9.3623
EID:

2-s2.0-0028333754

Part of ISSN: 00278424
Contributors: Renschler, M.F.; Bhatt, R.R.; Dower, W.J.; Levy, R.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Affinity panning of a library of peptides displayed on bacteriophages reveals the binding specificity of BiP

Cell
1993 | Journal article
DOI: 10.1016/0092-8674(93)90492-9
EID:

2-s2.0-0027484417

Part of ISSN: 00928674
Contributors: Blond-Elguindi, S.; Cwirla, S.E.; Dower, W.J.; Lipshutz, R.J.; Sprang, S.R.; Sambrook, J.F.; Gething, M.-J.H.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Generation and screening of an oligonucleotide-encoded synthetic peptide library

Proceedings of the National Academy of Sciences of the United States of America
1993 | Journal article
DOI: 10.1073/pnas.90.22.10700
EID:

2-s2.0-0027375520

Part of ISSN: 00278424
Contributors: Needels, M.C.; Jones, D.G.; Tate, E.H.; Heinkel, G.L.; Kochersperger, L.M.; Dower, W.J.; Barrett, R.W.; Gallop, M.A.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Phage power

Current Biology
1992 | Journal article
DOI: 10.1016/0960-9822(92)90368-K
EID:

2-s2.0-10244272286

Part of ISSN: 09609822
Contributors: Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Selective enrichment and characterization of high affinity ligands from collections of random peptides on filamentous phage

Analytical Biochemistry
1992 | Journal article
DOI: 10.1016/0003-2697(92)90252-3
EID:

2-s2.0-0026765338

Part of ISSN: 10960309 00032697
Contributors: Barrett, R.W.; Cwirla, S.E.; Ackerman, M.S.; Olson, A.M.; Peters, E.A.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Chapter 28. The Search for Molecular Diversity (II): Recombinant and Synthetic Randomized Peptide Libraries

Annual Reports in Medicinal Chemistry
1991 | Book
DOI: 10.1016/S0065-7743(08)61215-4
EID:

2-s2.0-0009761249

Part of ISSN: 00657743
Contributors: Dower, W.J.; Fodor, S.P.A.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Electroporation of bacteria: a general approach to genetic transformation.

Genetic engineering
1990 | Journal article
DOI: 10.1007/978-1-4613-0641-2_14
EID:

2-s2.0-0025581246

Part of ISSN: 01963716
Contributors: Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Peptides on phage: A vast library of peptides for identifying ligands

Proceedings of the National Academy of Sciences of the United States of America
1990 | Journal article
DOI: 10.1073/pnas.87.16.6378
EID:

2-s2.0-0024991625

Part of ISSN: 00278424
Contributors: Cwirla, S.E.; Peters, E.A.; Barrett, R.W.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Electroporation: a general approach to the introduction of macromolecules into prokaryotic and eukaryotic cells.

Australian journal of biotechnology
1989 | Journal article
EID:

2-s2.0-0024399235

Part of ISSN: 08193355
Contributors: Shigekawa, K.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Electroporation of eukaryotes and prokaryotes: A general approach to the introduction of macromolecules into cells

BioTechniques
1988 | Journal article
EID:

2-s2.0-0023766699

Part of ISSN: 07366205
Contributors: Shigekawa, K.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

High efficiency transformation of E.coli by high voltage electroporation

Nucleic Acids Research
1988 | Journal article
DOI: 10.1093/nar/16.13.6127
EID:

2-s2.0-0023948010

Part of ISSN: 03051048
Contributors: Dower, W.J.; Miller, J.F.; Ragsdale, C.W.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

High-voltage electroporation of bacteria: Genetic transformation of Campylobacter jejuni with plasmid DNA

Proceedings of the National Academy of Sciences of the United States of America
1988 | Journal article
DOI: 10.1073/pnas.85.3.856
EID:

2-s2.0-0011659752

Part of ISSN: 00278424
Contributors: Miller, J.F.; Dower, W.J.; Tompkins, L.S.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Gene amplification in a leukemic patient treated with methotrexate

Journal of Clinical Oncology
1984 | Journal article
DOI: 10.1200/JCO.1984.2.1.2
EID:

2-s2.0-0021338913

Part of ISSN: 0732183X
Contributors: Horns Jr., R.C.; Dower, W.J.; Schimke, R.T.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Coordinate regulation of two estrogen-dependent genes in avian liver.

Proceedings of the National Academy of Sciences of the United States of America
1980 | Journal article
DOI: 10.1073/pnas.77.8.4474
EID:

2-s2.0-0019052837

Part of ISSN: 00278424
Contributors: Wiskocil, R.; Bensky, P.; Dower, W.; Goldberger, R.F.; Gordon, J.I.; Deeley, R.G.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

2-5A synthetase: Assay, distribution and variation with growth or hormone status [21]

Nature
1979 | Journal article
DOI: 10.1038/278471a0
EID:

2-s2.0-0018343343

Part of ISSN: 00280836
Contributors: Stark, G.R.; Dower, W.J.; Schimke, R.T.; Brown, R.E.; Kerr, I.M.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier

Aplysia californica: Analysis of nuclear DNA in individual nuclei of giant neurons

Science
1971 | Journal article
DOI: 10.1126/science.172.3980.278
EID:

2-s2.0-0015228716

Part of ISSN: 00368075
Contributors: Lasek, R.J.; Dower, W.J.
Source: Self-asserted source
William J. Dower via Scopus - Elsevier
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