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Employment (1)

Kyowa Kirin (Japan): Tokyo, JP

2023-04 to present | Director (Medical Pharmacology)
Employment
Source: Self-asserted source
Junichi Enokizono

Education and qualifications (3)

The University of Tokyo: Tokyo, JP

2008-10-01 to present | Ph.D. (Guraduate School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Junichi Enokizono

The University of Tokyo: Tokyo, JP

1995-04-01 to 1997-03-31 | M.S. (Guraduate School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Junichi Enokizono

The University of Tokyo: Tokyo, JP

1991-04-01 to 1994-03-31 (Faculty of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Junichi Enokizono

Works (16)

Comprehensive Analyses of the Intracellular and in Vivo Disposition of Fab- Small Interfering RNA Conjugate to Identify Key Issues to Improve Its in Vivo Activity.

Drug metabolism and disposition: the biological fate of chemicals
2022-12-02 | Journal article
DOI: 10.1124/dmd.122.001098
PMID: 36460478
Contributors: Toshima A; Shiraishi Y; Daisuke Shinmi; Kagawa Y; Enokizono J
Source: Self-asserted source
Junichi Enokizono

Impact of Different Selectivity between Soluble and Membrane-bound Forms of Carcinoembryonic Antigen (CEA) on the Target-mediated Disposition of Anti-CEA Monoclonal Antibodies.

Drug metabolism and disposition: the biological fate of chemicals
2019-09-18 | Journal article
DOI: 10.1124/dmd.119.088179
PMID: 31533926
Contributors: Iwano J; Daisuke Shinmi; Masuda K; Murakami T; Enokizono J
Source: Self-asserted source
Junichi Enokizono

In vivo activation of PEGylated long circulating lipid nanoparticle to achieve efficient siRNA delivery and target gene knock down in solid tumors.

Journal of controlled release : official journal of the Controlled Release Society
2019-09-07 | Journal article
DOI: 10.1016/j.jconrel.2019.09.004
PMID: 31505222
Contributors: Sasayama Y; Hasegawa M; Taguchi E; Kubota K; Takeshi Kuboyama; Naoi T; Yabuuchi H; Shimai N; Asano M; Tokunaga A et al.
Source: Self-asserted source
Junichi Enokizono

Pharmacokinetic evaluation of liposomal nanoparticle-encapsulated nucleic acid drug: A combined study of dynamic PET imaging and LC/MS/MS analysis.

Journal of controlled release : official journal of the Controlled Release Society
2018-12-07 | Journal article
DOI: 10.1016/j.jconrel.2018.12.006
PMID: 30529725
Contributors: Hidefumi Mukai; Hatanaka K; Yagi N; Warashina S; Zouda M; Takahashi M; Narushima K; Yabuuchi H; Iwano J; Takeshi Kuboyama et al.
Source: Self-asserted source
Junichi Enokizono

Development and evaluation of a novel antibody-photon absorber conjugate reveals the possibility of photoimmunotherapy-induced vascular occlusion during treatment <i>in vivo</i>.

Oncotarget
2018-07-31 | Journal article
DOI: 10.18632/oncotarget.25831
PMID: 30140380
PMC: PMC6101140
Contributors: Isoda Y; Piao W; Taguchi E; Iwano J; Takaoka S; Uchida A; Yoshikawa K; Enokizono J; Arakawa E; Tomizuka K et al.
Source: Self-asserted source
Junichi Enokizono

Novel anticarcinoembryonic antigen antibody-drug conjugate has antitumor activity in the existence of soluble antigen.

Cancer medicine
2017-02-17 | Journal article
DOI: 10.1002/cam4.1003
PMID: 28211613
PMC: PMC5387159
Contributors: Daisuke Shinmi; Nakano R; Mitamura K; Suzuki-Imaizumi M; Iwano J; Isoda Y; Enokizono J; Shiraishi Y; Arakawa E; Tomizuka K et al.
Source: Self-asserted source
Junichi Enokizono

One-Step Conjugation Method for Site-Specific Antibody-Drug Conjugates through Reactive Cysteine-Engineered Antibodies.

Bioconjugate chemistry
2016-04-28 | Journal article
DOI: 10.1021/acs.bioconjchem.6b00133
PMID: 27074832
Contributors: Daisuke Shinmi; Taguchi E; Iwano J; Tsuyoshi Yamaguchi; Masuda K; Enokizono J; Shiraishi Y
Source: Self-asserted source
Junichi Enokizono

Effect of antigen-dependent clearance on pharmacokinetics of anti-heparin-binding EGF-like growth factor (HB-EGF) monoclonal antibody.

mAbs
2014-11-01 | Journal article
DOI: 10.4161/mabs.29792
PMID: 25517307
PMC: PMC4622948
Contributors: Kasai N; Yoshikawa Y; Enokizono J
Source: Self-asserted source
Junichi Enokizono

Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer.

American journal of translational research
2012-10-10 | Journal article
PMID: 23145209
PMC: PMC3493029
Contributors: Kasai N; Kobayashi K; Shioya S; Yoshikawa Y; Yotsumoto F; Miyamoto S; Eisuke Mekada; Enokizono J
Source: Self-asserted source
Junichi Enokizono

Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds.

Drug metabolism and disposition: the biological fate of chemicals
2008-03-05 | Journal article
DOI: 10.1124/dmd.107.019257
PMID: 18322075
Contributors: Enokizono J; Kusuhara H; Ose A; Schinkel AH; Sugiyama Y
Source: Self-asserted source
Junichi Enokizono

Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens.

Molecular pharmacology
2007-07-20 | Journal article
DOI: 10.1124/mol.107.034751
PMID: 17644650
Contributors: Enokizono J; Kusuhara H; Sugiyama Y
Source: Self-asserted source
Junichi Enokizono

Regional expression and activity of breast cancer resistance protein (Bcrp/Abcg2) in mouse intestine: overlapping distribution with sulfotransferases.

Drug metabolism and disposition: the biological fate of chemicals
2007-03-12 | Journal article
DOI: 10.1124/dmd.106.011239
PMID: 17353350
Contributors: Enokizono J; Kusuhara H; Sugiyama Y
Source: Self-asserted source
Junichi Enokizono

Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective alpha(2C)-adrenergic receptor antagonists.

Bioorganic & medicinal chemistry letters
2007-01-25 | Journal article
DOI: 10.1016/j.bmcl.2006.12.094
PMID: 17257841
Contributors: Hagihara K; Kashima H; Iida K; Enokizono J; Uchida S; Nonaka H; Kurokawa M; Shimada J
Source: Self-asserted source
Junichi Enokizono

Involvement of breast cancer resistance protein (BCRP/ABCG2) in the biliary excretion and intestinal efflux of troglitazone sulfate, the major metabolite of troglitazone with a cholestatic effect.

Drug metabolism and disposition: the biological fate of chemicals
2006-11-08 | Journal article
DOI: 10.1124/dmd.106.012567
PMID: 17093005
Contributors: Enokizono J; Kusuhara H; Sugiyama Y
Source: Self-asserted source
Junichi Enokizono

Structural basis of the interaction between IgG and Fcgamma receptors.

Journal of molecular biology
2000-01-01 | Journal article
DOI: 10.1006/jmbi.1999.3351
PMID: 10623521
Contributors: Koichi Kato; catherine sautes-fridman; Yamada W; Kobayashi K; Susumu Uchiyama; Kim H; Enokizono J; Galinha A; Kobayashi Y; wolf herman fridman et al.
Source: Self-asserted source
Junichi Enokizono

NMR analysis of the interaction between protein L and Ig light chains.

Journal of molecular biology
1997-07-01 | Journal article
DOI: 10.1006/jmbi.1997.1090
PMID: 9231896
Contributors: Enokizono J; Wikström M; Sjöbring U; Björck L; Forsén S; Arata Y; Koichi Kato; Shimada I
Source: Self-asserted source
Junichi Enokizono
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